Navigation Links
Danger in the blood: U-M scientists show how antibiotic-resisting bacterial infections may form
Date:8/15/2012

New research may help explain why hundreds of thousands of Americans a year get sick and tens of thousands die after bacteria get into their blood. It also suggests why some of those bloodstream infections resist treatment with even the most powerful antibiotics.

In a new paper in the Journal of Infectious Diseases, a team of University of Michigan researchers demonstrate that bacteria can form antibiotic-resistant clumps in a short time, even in a flowing liquid such as the blood.

The researchers made the discovery by building a special device that closely simulates the turbulence and forces of blood flow, and adding a strain of bacteria that's a common cause of bloodstream infections.

Tiny aggregates, or clumps, of 10 to 20 bacteria formed in the flowing liquid in just two hours about the same time it takes human patients to develop infections.

The researchers also showed that these clumps only formed when certain sticky carbohydrate molecules were present on the surface of the bacteria. The clumps persisted even when two different types of antibiotics were added suggesting that sticking together protects the floating bacteria from the drugs' effects.

When the researchers injected the clumps into mice, they stayed intact even after making many trips through the bloodstream. The clumps -- about the size of a red blood cell -- appeared to survive the filtering that normally takes place in the smallest blood vessels and defends the body against invaders.

"This work demonstrates that if you let bacterial pathogens grow in fluid dynamic environments like they encounter in the bloodstream, they start to take on features that you see in patients," says John Younger, M.D., M.S., senior author of the new paper and the leader of a team of physicians, engineers and mathematicians who have studied the origins of bloodstream infections for years. "The thing is to grow them in physical conditions that
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Hearing the telltale sounds of dangerous chemicals
2. Researchers discover molecule in immune system that could help treat dangerous skin cancer
3. NOAA researchers see dramatic decline of endangered white abalone
4. Movement patterns of endangered turtle vary from Pacific to Atlantic
5. First-ever release of endangered burying beetles in Missouri
6. UCSB researchers discover particularly dangerous Salmonella
7. Endangered bats find sanctuary in Israeli ghost bunkers
8. New iPad, iPhone app helps mariners avoid endangered right whales
9. Too dog tired to avoid danger
10. Genetic survey of endangered Antarctic blue whales shows surprising diversity
11. Commonly used herbicides seen as threat to endangered butterflies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Danger in the blood: U-M scientists show how antibiotic-resisting bacterial infections may form
(Date:10/29/2014)... 27, 2014 — Cambridge, MA and Hebei, China — ... complete, high quality sequencing of the Jujube genome. Jujube ... family, and the Jujube genome is particularly difficult to ... complicating factors. It is the first time that a ... This study has been recently published in ...
(Date:10/29/2014)... on a large cohort of kidney cancer patients in ... disease -- and reveals an apparent link between exposure ... in Romania. , The research, by an international team ... Quebec Innovation Centre in Montreal, underscores the importance of ... compound, found in plants of the Aristolochia genus, also ...
(Date:10/28/2014)... Institute of Health (NIH) announced awards to expand ... the National Center for Advancing Translational Sciences (ORDR-NCATS) ... Through the network, physician scientists at 22 consortia ... advance clinical research and investigate new treatments for ... possible by $29 million in fiscal 2014 funding ...
Breaking Biology News(10 mins):BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 2NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 3
... is available in German . , It is ... fate of individual cells during the early development of organisms. ... of molecular biologists led by Pia Aanstad of the University ... for the interpretation of the concentration of the signaling molecule ...
... Global Crop Diversity Trust announced today numerous new grant ... seed samples maintained in 1,500 crop genebanks around the ... protect food production from the ravages of climate change. ... innovative projects, including a search in Southeast Asia and ...
... experimental vaccine applied the surface of the skin appears ... Scientists from the Research Institute at Nationwide Children,s Hospital ... 109th General Meeting of the American Society for Microbiology ... show that transcutaneous immunization is an effective way to ...
Cached Biology News:Why the thumb of the right hand is on the left hand side 2Hunt for 'climate-ready' crops accelerates as organizations search seed collections worldwide 2Hunt for 'climate-ready' crops accelerates as organizations search seed collections worldwide 3Preventing ear infections in the future: Delivering vaccine through the skin 2
(Date:10/30/2014)... 2014 Spartan Bioscience announced today that ... System . It detects CYP2C19 genetic mutations in less ... The Spartan RX CYP2C19 System is the first near-patient ... in Canada. Due to the system’s ease of use, ... by healthcare professionals such as doctors, nurses, pharmacists, and ...
(Date:10/30/2014)... 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... management will present a company overview at the Nomura Biotechnology ... in Boston, MA. A ... "Investors & Media" section of the Company,s website, www.isispharm.com ... within 48 hours and will be archived for a limited ...
(Date:10/30/2014)... that devastated a wide swath of Colorado last year ... and other infrastructure had been upgraded or modernized, according ... Denver. , "People need to understand the importance and ... of structural engineering at the CU Denver College of ... "There is an assumption that a bridge will stand ...
(Date:10/27/2014)... and TORONTO , Oct. ... www.generex.com ) (OTCQB: GNBT) today announced two presentations ... triggered by its novel proprietary cancer immunotherapeutic AE37 ... breast cancer patients. The AE37 cancer vaccine is ... Express, Inc. ( www.antigenexpress.com ). The presentations are ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2CU Denver study says upgrading infrastructure could reduce flood damage 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4
... Cell Assurance, Inc. (SCLZ.PK) announced today that it has ... 10 pursuant to Section 12(g) of the Securities Exchange Act ... of December 31, 2009 and 2010 and for the years ... the Company will become an SEC reporting company and will ...
... Healthcare (NYSE: SI ) has appointed Gregory ... Healthcare in the U.S.A., effective June 1.  Sorensen succeeds ... Sorensen will also oversee the Canadian activities of Siemens ... Sorensen will be responsible for leading the marketing, ...
... Rules-Based Medicine, Inc. a leading provider of multiplexed protein ... Pasteur research project Milieu Interieur (the environment ... government.  The project will rely on RBM,s TruCulture®, an ... cellular interactions, to more accurately describe the complexities of ...
Cached Biology Technology:Gregory Sorensen to Head Siemens Healthcare U.S. and Canada Organizations 2Rules-Based Medicine, Inc. (RBM) Partners with Institut Pasteur to Boost Innovation in Translational Research 2Rules-Based Medicine, Inc. (RBM) Partners with Institut Pasteur to Boost Innovation in Translational Research 3Rules-Based Medicine, Inc. (RBM) Partners with Institut Pasteur to Boost Innovation in Translational Research 4
MpV17 transgene, murine homolog, glomerulosclerosis...
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
Human LT beta R/TNFRSF3 Phycoerythrin MAb (Clone 71319)...
Biology Products: