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Dana-Farber oncologists present at ASCO GU -- predict prostate cancer survival using Source MDx test
Date:2/27/2009

Orlando, Fla., February 27, 2009 Dana-Farber Cancer Institute (DFCI) and Source MDx today announced that Source MDx's whole blood RNA transcript-based Precision Profiles diagnostic test predicted survival in men with castration-resistant prostate cancer (CRPC). In a study of 62 CRPC patients, the model separated patients into a high risk group (survival less than 2.2 years) and a low risk group (survival greater than 2.2 years) (log rank p=0.00083). The six-gene CRPC Precision Profile was 96 percent accurate in predicting low risk CRPC patients alive at study end and 93 percent accurate in predicting high risk CRPC patients who died prior to study completion, suggesting that the model may be a powerful tool for stratifying CRPC patients in clinical trials. The Prostate Cancer Clinical Trials Consortium (PCCTC) will begin a prospective, multisite clinical trial to validate using Source MDx's six-gene CRPC Precision Profile to stratify aggressive vs. non-aggressive CRPC patients.

In the study, circulating tumor cell (CTC) counts were not predictive of survival. In fact, the highest CTC counts (931 and 263) were found in patients from the low risk group. The Halabi nomogram, a commonly used clinical prognostic factor that uses seven clinical measures, also predicted low and high risk groups of men with CRPC, based on evaluations in 56 patients, but was less discriminatory (p=0.012) than the six-gene Precision Profile.

William K. Oh, M.D., clinical director, Lank Center for Genitourinary Oncology, DFCI today presented the data from abstract 176 in a general poster session at the American Society for Clinical Oncology's Genitourinary Cancers Symposium. The study was co-investigated with Robert W. Ross, M.D., attending physician, Lank Center for Genitourinary Oncology, DFCI.

The PCCTC, a national clinical research group comprised of top U.S. research institutions, including DFCI, will conduct a prospective multi-site validation clinical tria
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Contact: Michelle Linn
linnmich@comcast.net
508-362-3087
Linnden Communications
Source:Eurekalert

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