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Damon Runyon grants Fellowship and Breakthrough Scientist awards to 21 top young scientists
Date:1/9/2012

is technology is limited because not all cellular memory is erased. He aims to improve the reprogramming process by removing proteins responsible for cellular memory. Stem cells have great potential in regenerative medicine, such as in renewing bone marrow following chemotherapy during cancer treatment.

Lora B. Sweeney, PhD, with her sponsors Christopher R. Kintner, PhD, at The Salk Institute for Biological Studies, La Jolla, California, and Thomas M. Jessell, PhD, at Columbia University, New York, New York, is using the frog as a model to study how neurons diversify in the spinal cord as limbs develop and a swimming tadpole becomes a hopping frog. Many different types of nerve cells, each with their own unique characteristics, make up the healthy nervous system. Understanding how a cell's fate is specified will provide the basis for understanding how cancer reprograms a cell.

Yanling Wang, PhD [Robert Black Fellow] with her sponsor Jeffery F. Miller, PhD, at University of California, Los Angeles, California, is studying Bacteroides fragilis, a common human gut bacterium that protects against inflammatory bowel diseases (IBD) in experimental models. This project will explore the mechanisms that contribute to bacterial colonization and long‐term maintenance in the gut. By combining bioinformatics, molecular genetics, protein biochemistry and innovative animal disease models, she hopes to better understand host‐microbe and microbe‐microbe interactions in the complex mammalian gut environment, and to potentially utilize B. fragilis as a preventative and therapeutic against IBD and/or colon cancer.

Rui Yue, PhD, with his sponsor Sean J. Morrison, PhD, at University of Texas Southwestern Medical Center, Dallas, Texas, is investigating the role of Leptin receptor signaling in blood stem cells (hematopoietic stem cells, HSCs). Leptin signals the nutritional status of the body and tightly controls energy metabolism and b
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Contact: Yung S. Lie, PhD
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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