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Damon Runyon grants Fellowship and Breakthrough Scientist awards to 21 top young scientists
Date:1/9/2012

to DNA and regulate gene expression. Certain TFs have well-established roles in cancer and other diseases. He is using chromatin immunopreciptation combined with high-throughput sequencing (ChIP-Seq) to map TF-DNA binding sites in a variety of yeast strains. This research is expected to be important for understanding the mechanisms controlling gene expression in humans and their variation across populations, thus providing insights into cancer and other diseases.

Maximilian W. Popp, PhD, with his sponsor Lynne E. Maquat, PhD, at University of Rochester School of Medicine and Dentistry, Rochester, New York, is focusing on the quality control mechanisms that cells utilize at the RNA level to ensure proper gene expression. Cells inspect and destroy aberrant mRNA messages using decay pathways; dysregulation of these RNA decay systems is implicated in various cancers. He will apply a new genetic screening method to identify components of RNA decay pathways and learn more about their role in cancer.

Leah R. Sabin, PhD, with her sponsor Gregory J. Hannon, PhD, at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, is studying the role of long noncoding RNAs (lncRNAs) in blood cell development. Although the precise function of most lncRNAs remains unclear, certain lncRNAs are involved in regulating gene expression and may therefore be important for proper blood cell maturation. Since several types of cancers arise from blood cell progenitors, understanding how lncRNAs function in these cells may provide novel diagnostic and therapeutic targets.

Peter J. Skene, PhD, with his sponsors Mark T. Groudine, MD, PhD, and Steven Henikoff, PhD, at Fred Hutchinson Cancer Research Center, Seattle, Washington, is studying the mechanisms underlying how cells maintain a specific gene expression profile unique to that cell type. While current technologies allow the reprogramming of differentiated cells into stem cells, the therapeutic use of th
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Contact: Yung S. Lie, PhD
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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