John J. Karijolich, PhD, with his sponsor Michael Hampsey, PhD, at UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, aims to define mechanisms involved in the regulation of gene expression, using a combination of biochemical and genetic approaches. An understanding of these mechanisms is key to understanding the development of cancer, and may potentially lead to novel cancer therapeutics.
Ralph E. Kleiner, PhD, with his sponsor Tarun M. Kapoor, PhD, at The Rockefeller University, New York, New York, is studying proteins called microtubules, which play a crucial role in the maintenance and proliferation of cancer cells. Microtubule function is regulated, in part, by chemical modifications or "flags" on the microtubule proteins. He aims to combine chemical, biochemical and biophysical approaches to better explain the role of these modifications on cell physiology and drug sensitivity. These studies will enable the identification of novel strategies for improving the efficacy of existing microtubule-targeted cancer drugs.
Ryota Matsuoka, PhD, with his sponsor Didier Y.R. Stainier, PhD, at University of California, San Francisco, California, is investigating how the nervous and vascular systems cooperate to establish precise patterns of networks. Neuronal and vascular networks are fundamental for normal tissue function and homeostasis, and abnormalities in these networks lead to tissue dysfunction and diseases, including cancer.
Robert K. McGinty, MD, PhD, with his sponsor Song Tan, PhD, at Pennsylvania State University, University Park, Pennsylvania, is examining the structure and function of enzymes called methyltransferases. As these enzymes are commonly misregulated in human leuk
|Contact: Yung S. Lie, PhD|
Damon Runyon Cancer Research Foundation