Robert K. Bradley, PhD (Damon Runyon Fellow '09-'11), Fred Hutchinson Cancer Research Center, Seattle, Washington
Alternative splicing, the process by which a single gene can give rise to multiple, distinct protein isoforms, is broadly dysregulated in many tumors. Recent research demonstrates that erroneous splicing can play important roles in tumor formation and growth, making it crucial that we understand the regulatory processes that give rise to aberrant splicing in cancers. In collaboration with clinicians, Dr. Bradley seeks to identify splicing events with important roles in tumor formation and maintenance. By combining computational and experimental techniques to understand the regulatory mechanisms underlying aberrant splicing, he aims to gain insight into fundamental tumor biology, potentially pointing the way to future therapeutics.
Dr. Bradley is now Assistant Member at the Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jason M. Crawford, PhD (Damon Runyon Fellow '09-'11), Harvard Medical School, Boston, Massachusetts
Small molecules produced by bacteria and fungi have provided many of our most successful anticancer drugs. These microbial products have also served as excellent probes for identifying new drug targets in a variety of cancers. Dr. Crawford will exploit the natural interactions between bacteria and animals to increase the production and identification of new products with anticancer activities. By understanding how these products are produced in the microbe, the pathways can then be engineered to produce a variety of pharmacologically-relevant molecules.
Dr. Crawford will also explore the chemical interactions that occur between humans and the bacteria on our skin and in our gut. Many of these bacteria help to digest food, produce vitamins, ward off pathogens, and train the immune system.
|Contact: Yung S. Lie, PhD|
Damon Runyon Cancer Research Foundation