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Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
Date:1/7/2013

metastasis, survival and response to chemotherapy. Translating these methods into the clinic is likely to have a profound effect on reducing morbidity in breast cancer and other cancer types.

Trudy G. Oliver, PhD
University of Utah Huntsman Cancer Institute, Utah

Many cancers initially respond to therapy. However, cancers often acquire resistance and stop responding to further treatment. Small cell lung cancer (SCLC) is an example of a cancer that is highly sensitive to initial treatment, but quickly acquires a vicious resistance resulting in a five-year patient survival rate of less than 4%. In order to combat drug resistance and improve the quality of life for patients with SCLC, it is important to understand the key genetic changes and cellular pathways that drive resistance.

Dr. Oliver will use the most innovative next-generation sequencing technologies to comprehensively identify critical genetic changes associated with resistance. These findings will be essential for understanding how lung cancer, and potentially other types of cancer, evades chemotherapy. In addition, this work will identify novel pathways that could be targeted to re-establish drug sensitivity and thereby provide new treatment options for patients with drug-resistant disease.

Bradley L. Pentelute, PhD
Massachusetts Institute of Technology, Massachusetts

Antibodies have proven to be powerful tools in cancer research, facilitating the elucidation of disease mechanisms and generating novel and effective anti-cancer therapeutics. However, antibody biotechnology is limited by one major factor: the inability of antibodies to effectively cross the cell membrane to reach the inside of the cell, or cytosol. A new strategy is clearly necessaryone based on facile and reliable delivery of active antibody-like molecules into various cell types.

Dr. Pentelute plans to construct a new, targeted delivery platform capable of in
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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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