Navigation Links
Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research

New York, NY (January 23, 2012) The Damon Runyon Cancer Research Foundation announced that five scientists with novel approaches to fighting cancer have been named 2012 recipients of the Damon Runyon-Rachleff Innovation Award. The grant of $450,000 over three years is awarded each year to early career scientists whose projects have the potential to significantly impact the prevention, diagnosis and treatment of cancer.

2012 Damon Runyon-Rachleff Innovators:

Gregory L. Beatty, MD, PhD [Nadia's Gift Foundation Innovator]
University of Pennsylvania, Philadelphia, Pennsylvania

Tumor-associated immune cells called macrophages are a key component of the tumor microenvironment and often portend a poor prognosis. Macrophages are critical regulators of tumor angiogenesis and metastasis. Interestingly, the function of macrophages is dependent on their surrounding microenvironment such that under certain conditions, macrophages can actually become tumor-suppressive. The central hypothesis of Dr. Beatty's work is that macrophages are an important yet pliable factor in tumor behavior, which can be therapeutically targeted and instructed to attack tumors and inhibit tumor growth.

Dr. Beatty will evaluate strategies to engineer macrophages to attack tumors and to resist signals produced within tumors that ordinarily prime macrophages with tumor-promoting properties. He aims to combine these macrophage-directed approaches with standard chemotherapy. The priority is to develop the necessary data to facilitate the rapid translation of this strategic approach to the clinic for treatment of patients with pancreatic cancer and other malignancies.

Jay R. Hesselberth, PhD
University of Colorado Denver, Aurora, Colorado

Most early detection strategies for cancer focus on identifying protein biomarkers or "molecular signatures" of disease. However, discovery of new biomarkers has lagged, due in large part to the inability to efficiently sift through complex cellular protein mixtures. As a result, the number of new FDA-approved biomarker tests has declined over the last decade, and the current rate of biomarker validation is only one per year.

As proteins can be very large, they are typically cleaved into smaller units called peptides for identification and analysis. The current technology for peptide identification is very slow and lacks the sensitivity and specificity required to quantify proteins in complex samples. Dr. Hesselberth proposes that a massive acceleration in the rate of peptide sequencing would significantly impact biomarker research. To accomplish this, he seeks to develop a highly parallel peptide sequencing platform with single molecule resolution that is orders of magnitude faster than existing technology. This new approach would transform our capability to identify protein and peptide biomarkers for use in the early detection of cancer.

Matthew R. Pratt, PhD
University of Southern California, Los Angeles, California

Cellular proteins are often modified with a "flag" that affects their function. One such modification is the monosaccharide N-acetyl-glucosamine (O-GlcNAc), which is required for normal development and proper regulation of many biological pathways. During metabolism, elevated glucose levels result in elevated O-GlcNAc modification of proteins.

One common feature of all cancers is an altered metabolism that helps to protect cancer cells from the challenging environments they encounter during tumorigenesis and metastasis. Dr. Pratt has uncovered a link between this change in metabolism and O-GlcNAc modification of proteins, which directly contributes to the proliferation and survival of cancer cells. He seeks to understand the details of this link and exactly how it contributes to disease. This approach will lead to a more complete understanding of how metabolism promotes cancer and may uncover new opportunities for treatment.

Eranthie Weerapana, PhD
Boston College, Chestnut Hill, Massachusetts

Understanding proteins dysregulated in cancer is a vital step toward the discovery of effective targets for treatment. Many cellular enzymes demonstrate aberrant activity in cancer, and a significant subset of them contain cysteine amino acid residues required for their function.

Dr. Weerapana aims to use sophisticated chemical genetic approaches to develop novel small molecules that selectively target these cysteines, thus blocking protein function. Her goal is to create a "chemical library" of these small molecules and use this library to identify compounds that affect cancer cell proliferation, migration and invasion in breast and ovarian cancer cell lines. The cellular protein targets of these molecules will be identified, followed by analysis of their roles in cancer development and progression. This multidisciplinary approach, encompassing aspects of synthetic chemistry, cell biology and proteomics, will identify new therapeutic targets and small molecule drug candidates for the diagnosis and treatment of cancer.

Feng Zhang, PhD
The Broad Institute of MIT and Harvard, Cambridge, Massachusetts

Recent genome sequencing studies have identified a large set of candidate genetic mutations implicated in a diverse range of cancer types. However, in order to determine the causal role of each mutation in disease risk and pathology, researchers must be able to test each mutation individually in cellular or animal models. This is severely limited by the difficulty of manipulating the genome of cells and organisms with precise control so that a specific disease can be definitively linked to single changes in the genome.

To address this challenge, Dr. Zhang proposes to engineer a comprehensive set of novel molecular tools to enable targeted modification of the mammalian genome. He will demonstrate the power of these tools by testing genetic mutations associated with neuroblastoma and glioma brain tumors. The development and application of these tools will establish a powerful new platform for investigating the underlying genetic and molecular mechanisms of cancer and will inform drug development. To ensure maximal benefit and impact for the cancer community and beyond, he will also facilitate teaching and rapid open-source distribution of all tools developed.

Funding Daring Research

The Damon Runyon-Rachleff Innovation Award funds cancer research by exceptionally creative thinkers with "high-risk/high-reward" ideas who lack sufficient preliminary data to obtain traditional funding. The awardees are selected through a highly competitive and rigorous process by a scientific committee comprised of leading cancer researchers who are innovators themselves. At the final stage of selection, candidates are screened by an in-person interview with committee members. Only those scientists with a strong vision and passion for curing cancer are selected to receive the prestigious award.

This program is possible through the generous support of Andy and Debbie Rachleff, the Island Outreach Foundation and Nadia's Gift Foundation.


Contact: Yung S. Lie, Ph.D.
Damon Runyon Cancer Research Foundation

Related biology news :

1. Damon Runyon grants Fellowship and Breakthrough Scientist awards to 21 top young scientists
2. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists
3. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
4. Damon Runyon Cancer Research Foundation awards breakthrough scientists
5. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists
6. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists
7. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
8. 2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
9. BIDMC scientist John Rinn, Ph.D., receives Damon-Runyon Rachleff Innovation Award
10. IBM Reveals Five Innovations That Will Change Our Lives Within Five Years
11. Surging Demand for Innovation Services Leads to Record Expansion for NineSigma
Post Your Comments:
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... findings on what they believe could be a new and helpful biomarker for ... research. Click here to read it now. , Biomarkers are components ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
Breaking Biology Technology: