Navigation Links
Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
Date:2/2/2011

in the field of cancer research regard these master regulators as the most desirable targets for drug discovery. Unfortunately, developing drugs against these proteins has proven to be technically difficult.

Dr. Bradner is using new chemical approaches to develop small molecule drugs directed at the master regulators of cancer cell growth. The primary focus of his efforts is a master regulator called Myc. Abnormal activation of Myc is one of the most common events in all human cancers. By targeting Myc in cancer cells, he hopes to discover new, prototype drugs that can be used as more effective targeted anti-cancer agents.

Joshua E. Elias, PhD
Stanford University School of Medicine, Stanford, California

A great deal of cancer research focuses on investigating the methods by which tumors cope with damage to their DNA. Less is known about the ways cancer cells deal with damage to any of the thousands of proteins necessary for cell survival. Cancerous cells often occupy environments that subject them to numerous stresses, including oxygen and nutrient depletion, which can lead to protein damage or misfolding. To survive and proliferate in these conditions, cancer cells use specific protective mechanisms to destroy or restore damaged proteins; in contrast, normal cells would die in such surroundings.

Cancer cells may, for example, activate degradation pathways to do away with dysfunctional proteins. Dr. Elias proposes that cancer cells may also promote long-term survival by dividing asymmetrically, thus producing one daughter cell free of damaged proteins. To test these ideas, he will measure the lifetimes of damaged proteins, model the processes cancer cells use to dispose of proteins, and investigate the ways by which these methods contribute to tumor formation. By understanding the mechanisms cancer cells depend on to escape death and promote growth, he hopes to discover new treatments and diagnostics, a
'/>"/>

Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Damon Runyon Cancer Research Foundation awards breakthrough scientists
2. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists
3. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists
4. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators
5. 2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
6. BIDMC scientist John Rinn, Ph.D., receives Damon-Runyon Rachleff Innovation Award
7. Columbia University uses technological innovation to study bone structure
8. 7th NIZO Dairy Conference to focus on flavor and texture, innovations in dairy
9. NIH Transformative Research Project Awards hasten innovation
10. WSJ honors university-created LLC with Innovation Award
11. Innovation Task Force urges approval of America COMPETES Act
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... to prevent Type 2 diabetes, don,t get your hopes up. ... The FASEB Journal , suggests that you don,t ... study compared genetically identical twins-one heavier and one leaner-and found ... those related to Type 2 diabetes, were found in both ... the onset of this type of diabetes is largely influenced ...
(Date:9/2/2014)... your integrity? Tell the truth; everyone has a tipping point. ... we,ll lie if the benefit is great enough. Now, scientists ... make that decision. , The result was published online ... "We prefer to be honest, even if lying is beneficial," ... associate at the Virginia Tech Carilion Research Institute , ...
(Date:9/2/2014)... limestone is well known as a result of ... (for example, Archaeopteryx). Now, for the first time, ... equivalent of these outcrops - discoveries which include ... treader. , Despite the abundance of fossils in ... obtained from the Late Kimmeridgian equivalents of these ...
Breaking Biology News(10 mins):What you eat and not just the number of calories, is a significant factor in diabetes risk 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4Exceptionally well preserved insect fossils from the Rhône Valley 2
... Calif. UC Riverside,s Alexander Raikhel , a professor ... National Academy of Sciences (NAS) for his excellence in ... is one of the highest honors given to a scientist ... inducted into the academy next April during its 147th annual ...
... the 61st Annual Meeting of the Rocky Mountain Section ... May 2009 in Orem, Utah. Utah Valley University ... building on the UVU campus. Brigham Young University is ... industry scientists, and graduate and undergraduate students, will highlight ...
... million in U.S. dollars have been awarded to ... studies related to asthma and other immune system ... extramural grants were awarded by the Biomedical Research ... and Research), the government agency driving Singapore,s transformation ...
Cached Biology News:UC Riverside professor receives top scientific honor 2UC Riverside professor receives top scientific honor 3Geoscientists meet to discuss Rocky Mountain geology 2Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants 2Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants 3Alzheimer's, asthma, cancer, malaria and TB focus of new Singapore grants 4
(Date:9/2/2014)... Sept. 2, 2014  Technology Applications International Corporation (the ... wholly-owned subsidiary Renuell Int,l, Inc. has signed an additional ... Administration ("NASA") at the Johnson Space Center in ... photos: tapplic.com/houstonphotos/ Charles ... pleased to announce our latest, exclusive agreement with NASA. ...
(Date:9/2/2014)... 2014  Xencor, Inc. (NASDAQ: XNCR ... antibodies for the treatment of autoimmune diseases, asthma ... appointment of Debra Zack , M.D., Ph.D., ... Lloyd Rowland , senior vice president, chief ... "Debra,s expertise in biologics clinical development and medical ...
(Date:9/2/2014)... and Rocky Mount, NC (PRWEB) September 02, 2014 ... today the establishment of its 11th clinical research site: ... Research has assumed ownership and operation of the clinical ... Mount, NC, further expanding PMG’s presence in eastern North ... additional 130,000 patients. For the patients in Rocky Mount ...
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8
... ... the availability of two new atomic force microscope (AFM) probes types with carbon nanotube ... CNT probes offer quantum improvements for AFM imaging, substantially improving results, reducing overall cost ... ...
... FRANCISCO, Calif., June 16 Sunesis Pharmaceuticals, Inc. (Nasdaq: ... and commercialization of new oncology therapeutics for the treatment of ... Executive Officer of Sunesis, will be presenting at the Jefferies ... New York on June 17, 2009. , , The ...
... 16 Three Rivers Pharmaceuticals announced today positive results ... Efficacy of Combined Therapy (DIRECT) clinical trial authored by ... , and colleagues at 44 centers in the United ... (SVR), was achieved demonstrating that INFERGEN provides a second ...
Cached Biology Technology:Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance 2Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance 3Three Rivers Announces Positive Results from Phase 3 DIRECT Trial of Once-Daily INFERGEN(R) with Ribavirin in Hepatitis C Virus Treatment Failures 2Three Rivers Announces Positive Results from Phase 3 DIRECT Trial of Once-Daily INFERGEN(R) with Ribavirin in Hepatitis C Virus Treatment Failures 3Three Rivers Announces Positive Results from Phase 3 DIRECT Trial of Once-Daily INFERGEN(R) with Ribavirin in Hepatitis C Virus Treatment Failures 4
Anti-LC3 Polyclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
Mouse monoclonal [SPM325] to Xanthine Oxidase, prediluted ( Abpromise for all tested applications). Antigen: C terminal 358 amino acid fragment of human xanthine oxidase. Entrez Gene ID: 749...
Rabbit polyclonal to Xanthine Oxidase (HRP) ( Abpromise for all tested applications). Antigen: Xanthine Oxidase (from Bovine Buttermilk) Entrez Gene ID: 7498 Swiss Protein ID: P47989...
... Disrupts biological cells for DNA isolation. ... well plates (includes 96 well plate ... lysis across the entire plate length ... Can be used for soil, ...
Biology Products: