Ari J. Firestone, PhD, with his sponsor Kevin M. Shannon, MD, at the University of California, San Francisco, California, is exploring novel strategies for inhibiting the cancer-causing activity of the N-Ras oncoprotein, which plays an important role in promoting cellular growth and survival. Ras mutations lead to uncontrolled proliferation in many types of cancer. Using mouse models of leukemia, he aims to determine whether disrupting the subcellular localization of Ras could be an effective therapeutic intervention.
Junjie U. Guo, PhD, with his sponsor David P. Bartel, PhD, at the Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, is investigating how regulatory RNAs function by interacting with their target RNAs. Misregulation of these interactions has been shown to contribute to tumorigenesis. He aims to develop a high-throughput experimental strategy that can identify these interactions within each RNA and between different RNAs.
Itamar Harel, PhD, with his sponsor Anne Brunet, PhD, at the Stanford University School of Medicine, Stanford, California, is studying the basic molecular components that characterize "young" and "aged" cellular states. Aging is associated with an increased onset of cancer. Ultimately, he hopes to design strategies to directly convert "old" cells from a patient into "young" ones, eventually developing more effective cancer therapies and prevention methods.
Serkan Kir, PhD, with his sponsor Bruce M. Spiegelman, PhD, at Dana-Farber Cancer Institute, Bo
|Contact: Yung S. Lie, PhD|
Damon Runyon Cancer Research Foundation