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Damon Runyon Cancer Research Foundation awards prestigious fellowships to 11 top young scientists
Date:1/21/2010

s studying proteins called insulin-like growth factors (IGFs), molecules that are essential for normal growth during development. When hyperactive, IGF signaling has been implicated in uncontrolled cell proliferation and can lead to a variety of cancers. His goal is to understand key events in IGF regulation and how these may go awry in the development of human cancers.

Bjrn F.C. Kafsack, PhD, [HHMI Fellow] with his sponsor Manuel Llins, PhD, at Princeton University, Princeton, New Jersey, is examining how cell behavior is dependent on cell density (the number of other cells nearby). He is using the parasite Plasmodium falciparum as an experimental model. His goal is to apply this knowledge to understanding how cancer cells respond to their surrounding environment, resulting in tumor growth and metastasis.

Rebecca S. Mathew, PhD, [HHMI Fellow] with her sponsor Danesh Moazed, PhD, at Harvard Medical School, Boston, Massachusetts, is studying how cell identity is maintained throughout the life of an organism. She is focusing on the role of a protein complex called CLRC in modifying chromosome architecture. Failure to maintain cell identity has catastrophic consequences, often resulting in cancer or other diseases.

Jelena Nedjic, PhD, with her sponsor Iannis Aifantis, PhD, at the New York University School of Medicine, New York, New York, aims to understand the role of molecules that regulate cellular migration and adhesion during the development and metastasis of T cell acute lymphoblastic leukemia (T-ALL), a blood cancer arising from transformed immune cells. The progression of the disease leads to severe metastasis to the central nervous system.

Duncan J. Smith, PhD, [HHMI Fellow] with his sponsor Iestyn Whitehouse, PhD, at Memorial Sloan-Kettering Cancer Center, New York, New York, is investigating how the higher-order structure of DNA is accurately transmitted when cells divide. Defects in this process are likely to
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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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