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Damon Runyon Cancer Research Foundation awards $3.6 M to 9 top young clinical investigators
Date:7/1/2013

n-Lilly Clinical Investigator] will use the Continuation Grant to investigate the impact of chemotherapy on pain processing pathways, which could predispose patients to chronic pain. She will also evaluate factors that could be used to predict which patients with aromatase inhibitor-associated pain will respond to a specific type of therapy called duloxetine. A greater understanding of why breast cancer survivors develop treatment-related pain could lead to prevention or better management of symptoms, thereby improving long-term quality of life.

Dr. Henry works under the mentorship of Daniel F. Hayes, MD, at the University of Michigan, Ann Arbor, Michigan.

Brian G. Till, MD

Certain types of lymphoma, such as the indolent B cell lymphomas and mantle cell lymphoma, are incurable with standard therapies. These diseases can, however, be cured using stem cell transplantation, in which immune T cells from the donor kill lymphoma cells. This procedure unfortunately carries the serious risk of graft-versus-host disease, which can be life-threatening.

In order to provide safer therapy options, Dr. Till [Damon Runyon-Pfizer Clinical Investigator] aims to develop a new treatment for lymphoma using patients' own T cells to fight their cancers: patient cells are collected, a gene is inserted into the cells that allows them to recognize and kill lymphoma cells, and then the cells are infused back into the patient. Using his Continuation Grant, he is leading a phase I clinical trial testing this treatment in lymphoma patients. He is optimistic that this strategy will translate into a safe, curative treatment for patients with lymphoma; insights from this work may help to advance similar treatments for other types of cancer.

Dr. Till works under the mentorship of Oliver W. Press, MD, PhD, at the Fred Hutchinson Cancer Center, Seattle, Washington.


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Contact: Yung S. Lie
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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