Navigation Links
Dad's life stress exposure can affect offspring brain development, Penn Study finds
Date:6/12/2013

PHILADELPHIA Sperm doesn't appear to forget anything. Stress felt by dadwhether as a preadolescent or adultleaves a lasting impression on his sperm that gives sons and daughters a blunted reaction to stress, a response linked to several mental disorders. The findings, published in a new preclinical study in the Journal of Neuroscience by researchers at the University of Pennsylvania, point to a never-before-seen epigenetic link to stress-related diseases such as anxiety and depression passed from father to child.

While environmental challenges, like diet, drug abuse, and chronic stress, felt by mothers during pregnancy have been shown to affect offspring neurodevelopment and increase the risk for certain diseases, dad's influence on his children are less well understood. The effects of lifelong exposures to dad on children are even more out of reach.

Now, a team of researchers led by Tracy L. Bale, PhD, associate professor of neuroscience in the Perelman School of Medicine Department of Psychiatry and the School of Veterinary Medicine Department of Animal Biology have shown that stress on preadolescent and adult male mice induced an epigenetic mark in their sperm that reprogrammed their offspring's hypothalamic-pituitary-adrenal (HPA) axis, a region of the brain that governs responses to stress. Surprisingly, both male and female offspring had abnormally low reactivity to stress.

This stress pathway dysregulationwhen reactivity is either heightened or reducedis a sign that an organism doesn't have the ability to respond appropriately to a changing environment. And as a result, their stress response becomes irregular, which can lead to stress-related disorders.

"It didn't matter if dads were going through puberty or in adulthood when stressed before they mated. We've shown here for the first time that stress can produce long-term changes to sperm that reprogram the offspring HPA stress axis regulation," said Bale.
'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Spontaneous gene glitches linked to autism risk with older dads
2. Anxious mice make lousy dads: study
3. Happy Fathers Day! Another reason why dads and hopeful dads should quit smoking now
4. Male snails babysit for other dads
5. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
6. Some corals like it hot: Heat stress may help coral reefs survive climate change
7. Lizard moms may prepare their babies for a stressful world
8. Researcher awarded $1 million for stress-associated disease and aging research
9. Low-income moms under stress may overfeed infants
10. Study offers new insights into the effects of stress on pregnancy
11. NUS-led research team discovers how bacteria sense salt stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NEW YORK , Jan. 21, 2015  Analyst Report Issued ... Credit Card Brands report showed that planet-wide, transactions at merchants ... 2011, while the total number of credit, debit, and prepaid ... the U.S. were victims of fraudulent card usage in 2012, ...
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... This news release is available in German . ... as popular as jogging. About ten million people in Germany are ... to reduce stress, lose ex- cess fat, and improve endurance. Running ... despite its numerous positive effects, jogging is a desirable sport with ...
... The Bahamas spanning almost two decades shows that female lemon ... give birth to their own young, confirming this behavior for ... and has resulted in the capture, tagging, and release of ... This article, published online on December 5 in ...
... Duke-NUS Graduate Medical School, which form Singapore,s largest academic ... to accelerate the discovery of treatments and cures. They ... Eureka Institute for Translational Medicine today. As ... and Duke-NUS join an elite group of academic medical ...
Cached Biology News:High-tech athletic shoe for pure running pleasure 2New finding shows that mother sharks 'home' to their birthplace to give birth, like salmon and sea turtles 2New finding shows that mother sharks 'home' to their birthplace to give birth, like salmon and sea turtles 3Singapore joins global translational medicine network as Asia-Pacific hub 2Singapore joins global translational medicine network as Asia-Pacific hub 3
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... 23, 2014 Earlier this year in a ... of the Adult Stem Cell Technology Center, LLC ( ASCTC ... unique property of adult tissue stem cells. His title ... Important for the Future,” embodied the essence of his message ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 The ... as its definition, classification, application and industry overview. ... and product cost structure. Production is separated by ... upstream raw materials, equipment, downstream client survey, marketing ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... report addresses regulatory oversight for emerging technologyWASHINGTON, March ... synthetic biology may be adequately addressed by the ... laboratories and manufacturing facilities. But further advances in ... challenges for U.S. government oversight, according to a ...
... group of executives who represent an array of energies ranging from solar ... to tread carefully when putting together U.S. energy policy. , ... Houston, ... a group of executives who represent an array of energies ranging from ...
... S.A. and,Solvay Pharmaceuticals Marketing and Licensing AG (subsidiary ... partnership agreement for the,promotion and distribution of Stallergenes ... of Independent States (CIS). , ... and a strong demand on the,part of the ...
Cached Biology Technology:Synthetic Biology: The Next Biotech Revolution Is Brewing 2Synthetic Biology: The Next Biotech Revolution Is Brewing 3Energy Leaders Gather in Houston; Call for Balanced, Careful Approach to Energy Policy 2Energy Leaders Gather in Houston; Call for Balanced, Careful Approach to Energy Policy 3Stallergenes Signs an Exclusive Partnership Agreement With Solvay Pharmaceuticals for the Promotion and Distribution of its Products in Russia and the CIS* 2Stallergenes Signs an Exclusive Partnership Agreement With Solvay Pharmaceuticals for the Promotion and Distribution of its Products in Russia and the CIS* 3
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
Biology Products: