Navigation Links
Dad's life stress exposure can affect offspring brain development, Penn Study finds
Date:6/12/2013

PHILADELPHIA Sperm doesn't appear to forget anything. Stress felt by dadwhether as a preadolescent or adultleaves a lasting impression on his sperm that gives sons and daughters a blunted reaction to stress, a response linked to several mental disorders. The findings, published in a new preclinical study in the Journal of Neuroscience by researchers at the University of Pennsylvania, point to a never-before-seen epigenetic link to stress-related diseases such as anxiety and depression passed from father to child.

While environmental challenges, like diet, drug abuse, and chronic stress, felt by mothers during pregnancy have been shown to affect offspring neurodevelopment and increase the risk for certain diseases, dad's influence on his children are less well understood. The effects of lifelong exposures to dad on children are even more out of reach.

Now, a team of researchers led by Tracy L. Bale, PhD, associate professor of neuroscience in the Perelman School of Medicine Department of Psychiatry and the School of Veterinary Medicine Department of Animal Biology have shown that stress on preadolescent and adult male mice induced an epigenetic mark in their sperm that reprogrammed their offspring's hypothalamic-pituitary-adrenal (HPA) axis, a region of the brain that governs responses to stress. Surprisingly, both male and female offspring had abnormally low reactivity to stress.

This stress pathway dysregulationwhen reactivity is either heightened or reducedis a sign that an organism doesn't have the ability to respond appropriately to a changing environment. And as a result, their stress response becomes irregular, which can lead to stress-related disorders.

"It didn't matter if dads were going through puberty or in adulthood when stressed before they mated. We've shown here for the first time that stress can produce long-term changes to sperm that reprogram the offspring HPA stress axis regulation," said Bale.
'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Spontaneous gene glitches linked to autism risk with older dads
2. Anxious mice make lousy dads: study
3. Happy Fathers Day! Another reason why dads and hopeful dads should quit smoking now
4. Male snails babysit for other dads
5. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
6. Some corals like it hot: Heat stress may help coral reefs survive climate change
7. Lizard moms may prepare their babies for a stressful world
8. Researcher awarded $1 million for stress-associated disease and aging research
9. Low-income moms under stress may overfeed infants
10. Study offers new insights into the effects of stress on pregnancy
11. NUS-led research team discovers how bacteria sense salt stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014) A rare genetic disorder known as Jacobsen ... recent joint investigation by researchers at San Diego State ... addition to suggesting better treatment options for people with ... the genetic underpinnings of autism., Jacobsen syndrome affects approximately ... of Health. It occurs in a person when there ...
(Date:9/17/2014)... team of Spanish researchers have obtained the first partial ... sixteenth century pig found at the site of the ... this ancient pig is closely related to today,s Iberian ... were crossed with modern Iberian pigs. , The study, ... evolutionary aspects of pig species, and particularly on that ...
(Date:9/17/2014)... After decades of decline, grasses have returned to ... eye, the marsh in those places seems healthy again, ... service of the marsh coastal protection remains ... ecosystem function hasn,t come back," said ecologist Mark Bertness, ... the study in the journal Biological Conservation . ...
Breaking Biology News(10 mins):A link between Jacobsen syndrome and autism 2Iberian pig genome remains unchanged after 5 centuries 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... in imaging technology using a combination of light and ... details inside the body. Access to this level of ... but it also has the potential to help health ... symptoms arise. Details describing this advance are published online ...
... Mich. Late-preterm babies those born between 34 and ... and emotional problems, regardless of maternal IQ or demographics, according ... the current edition of the journal Pediatrics . ... have been associated with such problems before, the study represents ...
... more than 60 guides and anglers in the Florida Keys ... assisting in the annual bonefish census. This year,s count, held ... 25-percent from an 8-year mean estimate of 316,805 bonefish to ... Jerry Ault, a fisheries scientist with the University of Miami,s ...
Cached Biology News:Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies 2Late-preterm babies at greater risk for problems later in childhood 2Fall bonefish census sounds warning bell that warrants careful future monitoring 2
(Date:9/17/2014)... , Sept. 17, 2014  PDL BioPharma, Inc. (PDL) (NASDAQ: ... registered accounting firm, Ernst & Young LLP ("EY") that it ... in a letter delivered to the Company on September 15, ... 16, 2014.  PDL has issued the following ... received a number of inquiries on the reason for the ...
(Date:9/17/2014)... 17, 2014 A long-term retrospective study ... irradiation (APBI) via interstitial brachytherapy suggests that women ... nodes could be suitable to receive the treatment. ... place these patients in the "unsuitable" category for ... ASTRO meeting, Beaumont Health System,s Peter Y. ...
(Date:9/17/2014)... 17, 2014 The global consumption of squalene / ... is a natural skin-identical chemical that finds applications in various ... supplements, pharmaceuticals, and in other applications like high grade lubrication, ... a few major players and is regionally segregated. Sophim ( ... Oil Co. Ltd. ( Japan ), SeaDragon Marine ...
(Date:9/17/2014)... , Sept. 17, 2014 /PRNewswire/ - Oncothyreon Inc. ... intends to offer and sell shares of its Common ... but concurrent underwritten public offerings.  The Series A Convertible ... Oncothyreon Common Stock, provided that conversion will be prohibited ... would beneficially own more than 4.99% of the Common ...
Breaking Biology Technology:PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 2Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 3Partial Breast Irradiation With Interstitial Brachytherapy Appears Appropriate For Women Previously Considered Unsuitable 4Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 2Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 3Oncothyreon Announces Proposed Public Offerings 2
... Communications , a provider of enterprise networking components, has ... of communications technology. , ,This funding, part of the ... competitive award process. It will enable the company to ... States Army . , ,The request for funding was ...
... I always like about the annual BIO International Conference ... Young always releases at this event its latest report ... Global Biotechnology Industry 2007. , ,This report is chock ... than Ernst & Young covers the global growth of this ...
... from the Public Company Accounting Oversight Board ... within information systems. There are numerous studies, including our ... area. It is worth making the investment to fix ... savings with your Sarbanes-Oxley compliance program. , ...
Cached Biology Technology:The state of global biotech: An Ernst & Young perspective 2The state of global biotech: An Ernst & Young perspective 3The state of global biotech: An Ernst & Young perspective 4The state of global biotech: An Ernst & Young perspective 5The state of global biotech: An Ernst & Young perspective 6Why IT change management is more important than ever 2Why IT change management is more important than ever 3Why IT change management is more important than ever 4
Mouse monoclonal antibody raised against a partial recombinant PRG4. NCBI Entrez Gene ID = PRG4...
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
...
Mouse polyclonal antibody raised against a partial recombinant CSRP3. NCBI Entrez Gene ID = 8048...
Biology Products: