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DNA's twisted communication
Date:2/28/2013

egulation that is often overlooked. Regulatory elements are not engaged in a one-to-one relationship with the specific gene that has the appropriate DNA sequence. The local genomic organisation, and 3D folding of DNA, might actually be more important factors that both modulate the action of regulation elements, and put them in contact with their target gene.

More research will be necessary to understand in detail the impact of the 3D structure of DNA on the communication between the various elements of the genome, and on the regulation of gene expression. Further down the line, this could also further our understanding of how genomic rearrangements might disrupt these 3D regulatory networks and lead to diseases and malformations.


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Contact: Isabelle Kling
isabelle.kling@embl.de
49-622-138-78355
European Molecular Biology Laboratory
Source:Eurekalert

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