Navigation Links
DNA's twisted communication
Date:2/28/2013

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements. Their findings, published today in Developmental Cell, shed new light on the importance of the genome structure for gene regulation.

Fgf8 is controlled by a large number of regulatory elements that are clustered in the same large region of the genome and are interspersed with other, unrelated genes. Both the sequences and the intricate genomic arrangement of these elements have remained very stable throughout evolution, thus proving their importance. By selectively changing the relative positioning of the regulatory elements, the researchers were able to modify their combined impact on Fgf8, and therefore drastically affect the embryo.

"We showed that the surprisingly complex organisation of this genomic region is a key aspect of the regulation of Fgf8," explains Franois Spitz, who led the study at EMBL. "Fgf8 responds to the input of specific regulatory elements, and not to others, because it sits at a special place, not because it is a special gene. How the regulatory elements contribute to activate a gene is not determined by a specific recognition tag, but by where precisely the gene is in the genome."

Scientists are still looking into the molecular details of this regulatory mechanism. It is likely that the way DNA folds in 3D could, under certain circumstances, bring different sets of regulatory elements in contact with each other and with Fgf8, to trigger or prevent gene expression. These findings highlight a level of complexity of gene r
'/>"/>

Contact: Isabelle Kling
isabelle.kling@embl.de
49-622-138-78355
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Quantum communication: Each photon counts
2. Toward reducing the greenhouse gas emissions of the Internet and telecommunications
3. NOAA: Underwater noise decreases whale communications in Stellwagen Bank sanctuary
4. Science reporters win ASM Public Communications Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
(Date:7/2/2015)... 2015 Research and Markets( ... "Next Generation Biometrics Market by Application, Technology, Function & ... their offering. The next generation biometrics market ... a CAGR of 17.9% between 2015 and 2020 ... the market. Safran SA ( France ...
(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... conservation efforts may have boosted the number of marine turtles ... , New research by the University of Exeter and Marine ... 2007), analyses 100 years of data. It shows an increase ... UK and French waters in the last twenty years. The ...
... UC San Diego have discovered that iron-containing nanoparticles being ... toxic to nerve cells and interfere with the formation ... essential nutrient for mammals and most life forms and ... said Sungho Jin, a professor of materials science at ...
... pulls out a tube. "This is a great one," she says, ... branch is speckled with white fluff. "It's growing really well," she ... close to his eye. "Yes," he says, with a boyish grin, ... fungus success story means nothing is growing at the back of ...
Cached Biology News:US conservation efforts bring more marine turtles to UK 2Widely used iron nanoparticles exhibit toxic effects on neuronal cells 2Widely used iron nanoparticles exhibit toxic effects on neuronal cells 3Fungal factories may save hemlock forests 2Fungal factories may save hemlock forests 3
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... uBiome, the ... up to $100,000 of microbiome sampling kits and full 16S laboratory analysis. The goal ... well-being. The winner will also have access to their own dashboard, enabling them to ...
(Date:7/7/2015)... ... July 07, 2015 , ... The global aptamers market ... growing at a CAGR of 17.89% between 2015 and 2020. The aptamer type ... Based on applications, the report is segmented into diagnostics, therapeutics development, R&D, and ...
(Date:7/7/2015)... , ... July 07, 2015 , ... ... driven community in the biometrical area. What began as a conference for European ... community for various functions in the biometrical area. Statistical Programmers, Data Managers and ...
(Date:7/7/2015)... Fargo, ND (PRWEB) , ... July 07, 2015 , ... ... the executive team as Vice President of Finance. Morse has an extensive background in ... pharmaceutical industries to the CSM team. In his new role, Morse will oversee all ...
Breaking Biology Technology:uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5PhUSE Delighted to Welcome Member Number 5.000 2CSM Appoints Michael Morse as Vice President of Finance 2
... Janssen Biotech, Inc. announced today that the ... Complete Response letter for its supplemental Biologics License ... in September 2010, seeks to expand the SIMPONI® ... structural damage, inducing major clinical response (MCR) and ...
... Calif., July 22, 2011 NeurogesX, Inc. (Nasdaq: ... novel pain management therapies, today announced that on July ... in connection with a private placement to a group ... conditions, is expected to receive approximately $20 million in ...
... (previously known as the Beijing Genomics Institute), the largest ... Zoology, Chinese Academy of Sciences, together published the whole ... ) in Genome Biology on July 6th, ... for evolutionary and biomedical research. Rhesus macaque, also ...
Cached Biology Technology:FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 2FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 3FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 4FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 5FDA Issues Complete Response Letter to Janssen Biotech, Inc. for SIMPONI® Supplemental Biologic License Application 6NeurogesX, Inc. Announces $20 Million Private Placement 2NeurogesX, Inc. Announces $20 Million Private Placement 3NeurogesX, Inc. Announces $20 Million Private Placement 4Whole sequence variation map reveals insight into evolutionary studies of rhesus macaque 2
... EVO Clinical is Tecans open platform for ... quality, safety and performance in the clinical ... provided by flexible barcode reading and sample ... that the system complies with the IVD-Directive* ...
... HRP Conjugate Stabilizer is an aqueous solution ... other non-toxic stabilizing chemicals in a MOPS ... 6.7. This product contains a combination ... ppm Proclin 300 (Rohm and Haas Company) ...
A collection of 42 spots with normal tissues from different organs of C57 mice, rat and human....
... Gene Frame® has been specifically designed ... feature the same dual strength adhesive ... range for easy removal after use. ... there are three sizes available. ...
Biology Products: