Navigation Links
DNA's twisted communication
Date:2/28/2013

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements. Their findings, published today in Developmental Cell, shed new light on the importance of the genome structure for gene regulation.

Fgf8 is controlled by a large number of regulatory elements that are clustered in the same large region of the genome and are interspersed with other, unrelated genes. Both the sequences and the intricate genomic arrangement of these elements have remained very stable throughout evolution, thus proving their importance. By selectively changing the relative positioning of the regulatory elements, the researchers were able to modify their combined impact on Fgf8, and therefore drastically affect the embryo.

"We showed that the surprisingly complex organisation of this genomic region is a key aspect of the regulation of Fgf8," explains Franois Spitz, who led the study at EMBL. "Fgf8 responds to the input of specific regulatory elements, and not to others, because it sits at a special place, not because it is a special gene. How the regulatory elements contribute to activate a gene is not determined by a specific recognition tag, but by where precisely the gene is in the genome."

Scientists are still looking into the molecular details of this regulatory mechanism. It is likely that the way DNA folds in 3D could, under certain circumstances, bring different sets of regulatory elements in contact with each other and with Fgf8, to trigger or prevent gene expression. These findings highlight a level of complexity of gene regulation that is often overlooked. Regulatory elements are not engaged in a one-to-one relationship with the specific gene that has the appropriate DNA sequence. The local genomic organisation, and 3D folding of DNA, might actually be more important factors that both modulate the action of regulation elements, and put them in contact with their target gene.

More research will be necessary to understand in detail the impact of the 3D structure of DNA on the communication between the various elements of the genome, and on the regulation of gene expression. Further down the line, this could also further our understanding of how genomic rearrangements might disrupt these 3D regulatory networks and lead to diseases and malformations.


'/>"/>

Contact: Isabelle Kling
isabelle.kling@embl.de
49-622-138-78355
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. Quantum communication: Each photon counts
2. Toward reducing the greenhouse gas emissions of the Internet and telecommunications
3. NOAA: Underwater noise decreases whale communications in Stellwagen Bank sanctuary
4. Science reporters win ASM Public Communications Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... While art and science are often ... connected than one might think. A Mesh Is Also a Snare, a group ... City Science Center’s Esther Klein Gallery (EKG) on August 17 and run through September ...
(Date:8/15/2017)... 15, 2017 After spending the past two years building ... data collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, ... support, adherence, and data collection vis a vis their members, under ... successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... ... 2017 , ... Kenall, a leader in sealed solid-state lighting, ... sealed and perform efficiently for years. The downlights are ideal for a variety ... such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food and pharmaceutical processing ...
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, a leading ... PCI Express, announced the release of SYZYGY™, a new open standard for connecting ... for a compact, low cost, low pin-count, high-performance connectivity solution between FPGAs and ...
Breaking Biology Technology: