Navigation Links
DNA variants may influence COPD patients' response to inhaled bronchodilators
Date:10/25/2013

Several novel gene variants may help explain the response of patients with chronic obstructive pulmonary disease (COPD) to inhaled bronchodilators, according to a meta-analysis reported today (Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston.

The meta-analysis used statistical methods to combine results from four individual studies with a total of 5,789 Caucasian patients with moderate to severe COPD.

Over 6.3 million unique single nucleotide polymorphisms (SNPs) were identified in the genotypes of the patients with COPD, which is a progressive breathing disorder that limits airflow in the lungs. The genotypes of over 700 African Americans with COPD also were analyzed.

"Identifying single nucleotide polymorphisms associated with bronchodilator responsiveness may reveal genetic pathways associated with the pathogenesis of COPD and may identify novel treatment methods," said Megan Hardin, M.D., Instructor of Medicine at Harvard Medical School and researcher in the Channing Division of Network Medicine at Brigham and Women's Hospital, Boston.

Dr. Hardin, who presented the research, added that multiple genetic determinants likely influence bronchodilator responsiveness. Functional analysis of the SNPs will be conducted, she added.

"As we continue to analyze the data, we expect to identify other important SNPs," said Craig P. Hersh, M.D., who headed the study and is Assistant Professor, Harvard Medical School, and faculty member in the Channing Division of Network Medicine at Brigham and Women's Hospital.

All of the subjects studied had significant histories of smoking, with most (4,561), over 10 pack-years. All patients were genotyped, and their lung function was tested by spirometry before and after they used the bronchodilator medication albuterol, which relaxes muscles in the airways and increases airflow to the lungs. Spirometry measures the volume and flow of air that is exhaled.<
'/>"/>

Contact: Cathy Yarbrough
press@ashg.org
858-243-1814
American Society of Human Genetics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Common genetic variants identify autism risk in high risk siblings of children with ASD
2. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
3. Gene variants may predict who will benefit from breast cancer prevention drugs
4. Penn: New variants at gene linked to kidney disease, sleeping sickness resistance
5. African-American study identifies 4 genetic variants associated with blood pressure
6. New NIH-funded resource focuses on use of genomic variants in medical care
7. Genetic variants associated with bronchodilator responsiveness
8. Circadian rhythms have profound influence on metabolic output, UCI study reveals
9. BUSM researchers identify genes that influence hippocampal volume
10. Fat outside of arteries may influence onset of coronary artery disease
11. New evidence that many genes of small effect influence economic decisions and political attitudes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... are athletes who have suffered concussions ready to return ... found that high school athletes who head back on ... a significant regression in their abilities to simultaneously walk ... seen in changes in their balance and/or altered walking ... of the 12 had returned to activity in less ...
(Date:8/20/2014)... 2014) Women who are poor experience higher cortisol ... elevated levels of the stress hormone, putting them ... according to a new research from the University of ... the American Journal of Human Biology , is ... it directly to the socioeconomic status of their mothers ...
(Date:8/20/2014)... and POINT ROBERTS, Washington , ... Play a Key Role in Addressing Security Concerns in the ... a global news source covering leading sectors including biometrics, issues ... market. Jason Peaslee , Managing Partner at ... and Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: ...
Breaking Biology News(10 mins):Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3CU Denver researcher shows economic disparities impact infant health 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7
... from the talents of Rembrandt, Van Gogh and other ... of colors on a palette. In a similar manner, ... (NIST) have created an innovative device called the "microfluidic ... concentration across an areain a miniature chamber about the ...
... WINSTON-SALEM Rates of severe childhood obesity have tripled in ... diabetes and heart disease, according to a report in ... Hospital, part of Wake Forest University Baptist Medical Center. ... obese, which impacts their overall health," said Joseph Skelton, M.D., ...
... Large trees have declined in Yosemite National Park ... play a role. The number of large-diameter trees ... and 1990s. U.S. Geological Survey and University of Washington ... from 1932� to the most recent records from 1988�. ...
Cached Biology News:'Microfluidic palette' may paint clearer picture of biological processes 2Research shows rates of severe childhood obesity have tripled 2
(Date:8/19/2014)... XenoTech announces an exclusive partnership with ... from bioactive small molecules. Based on an ... convenient and timely assessment of critical metabolite and ... of Commercial Operations, Christian Darabant, “the value of ... be measured directly by comparison with the approximate ...
(Date:8/19/2014)... CSSi, the leader in patient recruitment solutions ... of the company,s Medical and Clinical Advisory Board ("MCAB") ... William E. Gannon, Jr. to the MCAB. ... The MCAB, with Dr. Gannon,s leadership, will help ... set strategic goals for the advancement and development of ...
(Date:8/19/2014)... ROCKVILLE, Md. , Aug. 19, 2014 /PRNewswire/ ... a biotechnology company developing novel anti-infective biologic and ... infections and diseases, announced today that its novel ... highlighted at the 54 th Interscience Conference ... in Washington D.C. ...
(Date:8/19/2014)... Sales Horizons, a leader in sales ... sales skills training course to help companies develop ... staff spend the majority of their time on client ... or physician practice – providing support and education to ... Sales Horizons believes clinical staff are and should be ...
Breaking Biology Technology:Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3
... powered by ForceLogix, on-demand technology, wins Ventana ... and BRACKNELL, U.K., Nov. 12 ForceLogix ... Operational Performance,Leadership Award for Sales, honoring the ... and technology for optimal sales,business impact. ...
... /Xinhua-PRNewswire-FirstCall/ -- Discas, Inc. (Pink,Sheets: DSCS.PK), ("the Company") ... into a stock purchase agreement with SNX Organic ... is Beijing Shen,Nong Xing Technology Co. Ltd. ("BSNX"), ... in the research and development of,green and organic ...
... Lev Pharmaceuticals, Inc.,(OTC Bulletin Board: LEVP.OB) today announced that it will conduct a,conference ... Time (ET), in conjunction with the release of its financial,results for the third ... ET on Tuesday, November 13,2007. DATE: ... 1PM ET ...
Cached Biology Technology:ForceLogix, Innovex Win Sales Operational Performance Award 2ForceLogix, Innovex Win Sales Operational Performance Award 3Discas, Inc. Sells Shares to SNX Organic Fertilizers, Inc. 2Lev Pharmaceuticals Invites You to Participate in its Q3'07 Earnings Results Conference Call and Webcast 2
... Inhibitors have broad spectrum RNase inhibitory properties, ... the neutral type (1). The 50kDa protein ... to RNases in a 1:1 ratio. The ... Ribonuclease Inhibitor to RNase (e.g., RNase A) ...
...
Canine Aortic Smooth Muscle Cells (CnAOSMC) (>500,000 cells)...
... For nucleofection of optimized cell lines ... including the nucleofection parameters. Nucleofector Kits are ... Device., Different cell lines can be transfected ... viabilities are given in brackets in percent ...
Biology Products: