Navigation Links
DNA template could explain evolutionary shifts
Date:6/21/2009

he coding region of genes).

"This phenomenon occurs throughout the genome," said Dr. Feng Zhang, a postdoctoral associate in Lupski's laboratory and the first author of the report.

In studies of subjects with abnormalities in the gene associated with Charcot-MarieTooth type 1A (PMP22), the researchers found that the fork stalling, template switching phenomenon explained the changes, from those that involved triplication of a gene to others that resulted from shuffling within an exon.

Studies of one family two children and a mother demonstrated that the event occurred during mitosis or cell division, a significant finding that further confirms the significance of the event.

The researchers noted that finding this mitotic rearrangement of the gene in the mother, who did not have the disorder, of two children with a neuropathy suggests that the mechanism might be considered in genetic counseling about the risk of having another child with the disorder.

The scientists wrote, "We propose that FoSTeS/MMBIR may be a key mechanism for generating structural variation, particularly nonrecurrent CNV (copy number variation), of the human genome. "

The observation of mosaicism for an apparent mitotically generated, FoSTeS/MMBIR-mediated complex PMP22 rearrangement in the unaffected mother of two children with neuropathy suggests this mechanism can have implications for genetic counseling regarding recurrence risk.


'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Using evolution, UW team creates a template for many new therapeutic agents
2. Newly created cancer stem cells could aid breast cancer research
3. Obesity and lack of exercise could enhance the risk of pancreatic cancer
4. Finding that 1-in-a-billion that could lead to disease
5. 60 second test could help early diagnosis of common brain diseases
6. Auto immune response creates barrier to fertility; could be a step in speciation
7. Paracetamol, one of most used analgesics, could slow down bone growth
8. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
9. Thousands of starving children could be restored to health with peanut butter program
10. Nanotech could make solar energy as easy and cheap as growing grass
11. CO2 emissions could violate EPA ocean-quality standards within decades
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... SANTA CLARA, California , 23 de ... anuncia el lanzamiento del Sistema 1290 Infinity ... serie 1200 de Infinity en su portafolio ... los técnicos, científicos y directores de laboratorio ... calidad analítica excepcional, facilidad de uso y ...
(Date:9/23/2014)... immediate welfare consequences of removing infant chimpanzees from their ... long-term impacts of this type of early life experience. ... observed 60 chimpanzees and concluded that those who were ... by humans as pets or performers are likely to ... multi-institutional research project, published today in the open-access journal ...
(Date:9/22/2014)... Chicago have shown that after a long stay in ... pathogenic microbe species remain behind in patients, intestines. The ... can become deadly when provoked by conditions that mimic ... published in mBio , the online open-access journal ... better monitoring and treatment of ICU patients who can ...
Breaking Biology News(10 mins):Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 2Agilent Technologies anuncia el lanzamiento del Sistema 1290 Infinity II LC 3Chimpanzees raised as pets or performers suffer long-term effects on their behavior 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 3
... (FiO), the 91st Annual Meeting of the Optical Society ... San Jose, Calif., alongside Laser Science XXIII, the annual ... Science. Reporters interested in obtaining a badge to ... cmorri@osa.org . FiO RESEARCH HIGHLIGHTS ...
... Makes Tuna That Tastes Good, But These Bluefin Are ... bluefin tuna caught in the Gulf of Maine has ... University of New Hampshire have found by analyzing detailed ... Fishermans Co-op. The findings, published this week in Fishery ...
... the social habits of living cells an innovation ... help fight diseases such as cancer and diabetes. ... six countries, The Manchester Centre for Integrative Systems Biology ... research into an emerging field of science and engineering ...
Cached Biology News:Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 2Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 3Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 4Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 5Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 6Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 7Restoring sight, advances in fertility treatments and better visibility for pilots at FIO 8Condition of bluefin tuna in gulf of maine is declining 2Condition of bluefin tuna in gulf of maine is declining 3Social habits of cells may hold key to fighting diseases 2
(Date:9/23/2014)... Texas (PRWEB) September 23, 2014 ... the current state of the Phenolic Resin industry ... overview of the industry, including definitions, applications and ... domestic market analysis are provided with a focus ... the market. A comparison between the international and ...
(Date:9/23/2014)... 2014 Research and Markets  has ... for Research and IVD Applications (Mass Spectrometry, Chromatography, ... their offering. This report defines ... in their research use and in IVD.  Proteomics ... of the structure and function of proteins. This ...
(Date:9/23/2014)... September 23, 2014 Proove Biosciences ... presented industry leading research and data on the association ... the American Academy of Pain Management’ s ... Phoenix, Arizona at the , Proove Biosciences ... gender and genetic predisposition to opioid misuse risk in ...
(Date:9/23/2014)... , Sept. 23, 2014  Age Defying Dermatology ... Noodleman , has become one of the first clinics ... only "picoseconds" aesthetic laser for tattoo removal. The treatment ... better results. "For years, tattoo removal has been a ... Dr. Noodleman. "This is an opportunity to erase tattoo ...
Breaking Biology Technology:Phenolic Resin Industry (International, China) Development Policy and Plan Now Available at ReportsnReports.com 2Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 2Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 3Proteomics Markets for Research and IVD Applications (Mass Spectrometry, Chromatography, Microarrays, Electrophoresis, Immunoassays, Other Technologies) 4Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3Age Defy Now Offers World's Most Advanced Technology for Tattoo Removal 2
... DURHAM, N.C. -- Duke University and United States Army ... and diaper rash preventative can be made to produce ... Duke adjunct physics professor Henry Everitt, chemistry professor Jie ... that adding sulfur to ultra-fine powders of commonplace zinc ...
... 17 St. Joseph,s Hospital and Medical Center, Phoenix, today ... Clinical InfoNET videoconferencing system to connect specialist ... This program will include the Barrow Neurological Institute, as ... , With the objective of ...
... Calif., Dec. 17 Senetek PLC,(OTC Bulletin Board: SNKTY), ... that target the science of healthy aging, today,announced that ... proposed at the Annual General Meeting of Shareholders held ... "We are pleased with the results of the ...
Cached Biology Technology:Duke researchers coax bright white light from unexpected source 2Duke researchers coax bright white light from unexpected source 3St. Joseph's Hospital and Medical Center to Utilize Clinical InfoNET System for Physicians 2St. Joseph's Hospital and Medical Center to Utilize Clinical InfoNET System for Physicians 3Senetek PLC Announces 2008 Annual General Meeting Voting Results 2
Request Info...
... The Cetac Ultrasonic Nebulizers are available in two ... difference between these two models is that the ... to create a drier aerosol for improved detection ... detection limits for a range of elements by ...
... inhibition of RNase A-type ribonucleases Product Description: ... nonhuman origin that binds noncovalently and inactivates ... B, and C). It does not interfere ... or CL3. QIAGEN RNase Inhibitor inhibits greater ...
... is >95%\nNEN Radiolabeled Ligands\n\nReceptor-related research has long ... new radiolabeled ligands selected to keep pace ... range of products and services for receptor ... state-of-the-art radioligands. If you do not find ...
Biology Products: