Navigation Links
DNA sewing machine
Date:7/10/2008

Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them.

Scientists can diagnose genetic disorders such as Down's syndrome by using gene markers, or "probes", which bind to only highly similar chains of DNA. Once bound, the probe's location can be easily detected by fluorescence, and this gives information about the gene problem.

Detecting these probes is often a slow and difficult process, however, as the chains become tightly coiled. The new method presented by Kyohei Terao from Kyoto University, and colleagues from The University of Tokyo, uses micron-sized hooks controlled by lasers to catch and straighten a DNA strand with excellent precision and care.

"When a DNA molecule is manipulated and straightened by microhooks and bobbins, the gene location can be determined easily with high-spatial resolution," says Terao.

The team used optical tweezers tightly focused laser beams to control the Z-shaped micro hook and pick up a single DNA "thread". The hook is barbed like an arrow, so the thread can't escape. When caught on the hook, the DNA can be accurately moved around by refocusing the lasers to new positions.

But just like thread in a sewing machine, a long DNA chain can be unwieldy so the researchers built micro "bobbins" to wind the chain around. The lasers move one bobbin around another, winding the DNA thread onto a manageable spindle.

It is "an excellent idea to fabricate unique microtools that enables us to manipulate a single giant DNA molecule", says Yoshinobu Baba, who researches biologically useful microdevices at Nagoya University, Japan. The technology will also be useful for a number of other applications including DNA sequencing and molecular electronics, he adds.


'/>"/>

Contact: Kyohei Terao
k.terao@kt5.ecs.kyoto-u.ac.jp
81-757-533-560
Royal Society of Chemistry
Source:Eurekalert  

Page: 1

Related biology news :

1. Deep into the machinery of adult fragile X
2. Memory machine
3. Green alga genome project catalogs carbon capture machinery
4. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
5. An attractive man-machine interface
6. Core blimey! University of Leicester scientist calls for geological time machine
7. Yale scientists visualize the machinery of mRNA splicing
8. A study reveals how cells communicate to activate the cell division machinery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA sewing machine
(Date:6/25/2015)... 2015  Imagine a tool specifically designed to help ... life. That,s exactly what USANA,s True Health Assessment ... portable health program provides a personalized approached to measuring ... your lifestyle and nutrition. At the ... night, USANA,s THA was honored with the Industry Innovation ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/24/2015)... , June 24, 2015 Biometry ... with emerging biometric password solution one face in. ... one face in, entering the ... ground-breaking and affordable multifactor-authentication biometric answer to the ... technology, provided in partnership with KeyLemon, one face ...
Breaking Biology News(10 mins):@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2
... (FEBRUARY 7, 2008) Madagascars turtles and tortoises, which ... continue to crawl steadily toward extinction unless major conservation ... the Wildlife Conservation Society and other groups. The ... city Antananarivo, said there is still hope to save ...
... found that moderate exposure to alcohol and stress during ... monkeys babies. In human children, sensitivity to touch is ... 5 percent of children who over-respond to sensory information. ... problems, early identification and treatment are important. Children who ...
... has used an engineering approach to show that complex biological ... what goes into and out of the system. Such ... at the inner workings of a complicated biological system-such as ... in their natural state. The MIT researchers focused on ...
Cached Biology News:Madagascar's tortoises are crawling toward extinction, groups say 2Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity 2MIT applies engineering approach to studying biological pathways 2
(Date:7/24/2015)... ... July 24, 2015 , ... RURO’s ... modern scientific or pharmaceutical laboratory. FreezerPro® is an intuitive, fast, reliable and ... a sample is located even before opening the freezer door! Popular features ...
(Date:7/23/2015)... IL (PRWEB) , ... July 23, 2015 , ... The ... member, is pivotal in the management of a brain tumor diagnosis. The American Brain ... members at the ABTA’s 2015 Patient and Family Conference, July 24-25 in Chicago. ...
(Date:7/23/2015)... , ... July 23, 2015 , ... One hundred years ... the 1915 National Model Aeroplane Competition, with hopes of winning the Henry S. Villard ... its centennial. , Participants will have the opportunity to build a Free Flight fantasy ...
(Date:7/23/2015)... ... 23, 2015 , ... July 23, 2015, Chicago - Advances ... options with fewer side effects, according to Erik P. Sulman, MD, PhD, associate ... the American Brain Tumor Association (ABTA) National Patient and Family Conference in Chicago, ...
Breaking Biology Technology:RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 2RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 3RURO, Inc. Partners with Integrated Systems Engineering to Provide Comprehensive LIMS Software to Biobanks 4Reframing the Caregiver and Patient Mindset: Coping with the ‘New Normal’ 2Reframing the Caregiver and Patient Mindset: Coping with the ‘New Normal’ 3Academy of Model Aeronautics to Start Online Fantasy Flight Competition 2Radiation Oncology Advances Improve Safety and Efficacy of Treatment for Brain Tumors 2Radiation Oncology Advances Improve Safety and Efficacy of Treatment for Brain Tumors 3
... , , , Problems with the ... PCR* are an everyday occurrence in the lab. For example, , ... or even prevent, further analyses (cycle sequencing, mutation detection, ... result. In such cases, PCR , conditions must be ...
... , , , , , ... mRNA expression , pattern of a cell is examined in ... exogenous influences such as viral infections or medical treatment. , ... to cDNA. If all isolated mRNAs of a cell ...
... , , , , , , ... Experimental Immunopharmacology, Research Center Borstel, Parkallee 22, , D-23845 Borstel, Germany. , ... email: jvdbosch@fz-borstel.de , , ... a new commercial PCR enhancer for , improving PCR efficiency: ...
Cached Biology Technology:Using Gradient PCR to determine the optimum annealing temperature. 2Normalizing cDNA libraries using the EppendorfThermomixer 2Normalizing cDNA libraries using the EppendorfThermomixer 3Normalizing cDNA libraries using the EppendorfThermomixer 4Enhancing PCR* Efficiency with MasterTaq 2Enhancing PCR* Efficiency with MasterTaq 3Enhancing PCR* Efficiency with MasterTaq 4Enhancing PCR* Efficiency with MasterTaq 5
Immunogen: Synthetic peptide: S(399) P W S E L E F Q F P D D K D P V W E F(418) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
Biology Products: