Navigation Links
DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
Date:8/15/2007

For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding of human biology, such as in stem cell research.

Faithful duplication of the genome (the hereditary information that is encoded in genetic materials known as DNA) ensures that daughter cells inherit a complete set of genetic materials identical to parent cells. This duplication occurs in the section of the cell cycle known as the S-phase. Extensive research on the budding yeast, an organism often used in modern cell biology research, had revealed that the replication process is initiated at hundreds of origins in the S-phase. However, because previous studies focused on the replication timing and initiation sites, but not on the efficiency, it was thought that replication efficiency decreased as the S-phase progressed.

In a paper published in PLoS ONE in August 2007, GIS scientists described how they were able to determine the replication timing and efficiency at the various loci in the genome. Specifically, replication efficiency was found to be low at the beginning of the S-phase, and increased at the later stage of this phase.

GIS Group Leader and the corresponding author of the publication, Dr Liu Jianhua, said, Our evidence strongly supports the stochastic model for the regulation of DNA replication in high eukaryotes (organisms whose cells are organised into complex structures by internal membranes and a cytoskeleton) such as humans. We have shown that replication efficiency can be directly determined on a genomic scale. More significantly, our study provides for a novel methodology for the analysis of replication efficiencies at a genomic level in other species, and this is a very important step for the advancement of research in fundamental biology.


'/>"/>

Contact: Winnie Serah Lim
limcp2@gis.a-star.edu.sg
64-788-013-973-07884
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Unchecked DNA replication drives earliest steps toward cancer
2. Novel mechanism for DNA replication discovered
3. UW scientists unravel critical genetic puzzle for flu virus replication
4. Enzyme inhibitors block replication of SARS virus
5. ANU scientists crack DNA replication mystery
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. A first glimpse of the influenza replication machine
8. Common mechanisms for viral DNA replication
9. Crickets finicky mating behavior boosts biodiversity
10. Remote control flies? Fly behavior controlled by laser light
11. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... CT ., Aug. 20, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces it has joined The Smart Card Alliance and ... Smart Card Alliance and the Smart Card Alliance Latin ... visibility to industry peers and thought leaders promoting adoption ...
(Date:8/18/2015)... , Aug. 17, 2015 Research and ... of the "Global Biometric Authentication & Identification ... Estimation & Forecast, 2015-2020" report to their ... and identification systems market is expected to grow ... to 2020 and generate over $25 billion (approximately) ...
(Date:8/12/2015)... As the digital payment services ... advanced biometrics technology is accelerating beyond expectations.  While the ... using their credit cards, the digital currency, mobile payment ... services led by companies in the space such as ... (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ...
Breaking Biology News(10 mins):NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... their metabolism and “hibernate” to conserve energy, revealing a ... and metabolic disorders, UT Southwestern Medical Center researchers have ... called fibroblast growth factor 21 (FGF21), are described for ... in Cell Metabolism. , FGF21, triggered ...
... it does to an alpine ibex. , According ... ibex demonstrate a correlation between horn growth and genetic ... diversity correlates with a greater chance of survival. ... the genetic quality of the ibex—and the bigger, the ...
... detected from space for the first time using optical ... aboard Envisat. The ability to monitor Sargassum globally will ... the ocean and better predict climate change. Credit: ESA ... ships in its dense floating vegetation, has been detected ...
Cached Biology News:Hormone helps mice 'hibernate,' survive starvation 2Bigger horns equal better genes 2Envisat captures first image of Sargassum from space 2
(Date:9/1/2015)... ... 01, 2015 , ... A new host-based therapy for Ebola, ... Keck Graduate Institute and its collaborators. The discovery has the potential to speed ... on August 27 by Scientific Reports, an open access research journal from the ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... bring together supply chain risk management and resiliency practitioners with luminaries and thought ... best practices, and be recognized for their innovations and performance excellence. At that ...
(Date:8/31/2015)... 31, 2015 Research and Markets ( http://www.researchandmarkets.com/research/v7fdpx/argentina ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Argentina Biomedical Sensors market is estimated at $0.17 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
Breaking Biology Technology:Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2New Down syndrome therapy discovered 2
... ARUP Laboratories, a national,clinical and anatomic pathology reference ... development, announced today that it has,entered into a ... nationwide network affiliation and a principal provider of,business ... effective June 17, 2008, offers special pricing to ...
... to Ovarian Cancer Treatment, Predicting Risk of ... From Non-Small Cell Lung Cancer, In Addition, the Company has Identified Unique ... as the Basis for a Future ... Test for Colon Cancer, ...
... Inc.,(Nasdaq: MEDX ) announced today that it is ... at 11:15 a.m. Eastern Time on,Wednesday, June 25, 2008. ... in the Investor Relations section of the Medarex website ... will be available,following the event., About Medarex, ...
Cached Biology Technology:ARUP Laboratories Partners With Pathology Service Associates 2ARUP Laboratories Partners With Pathology Service Associates 3Rosetta Genomics Announces Three New Diagnostic Tests to Enter Development 2Rosetta Genomics Announces Three New Diagnostic Tests to Enter Development 3Rosetta Genomics Announces Three New Diagnostic Tests to Enter Development 4Rosetta Genomics Announces Three New Diagnostic Tests to Enter Development 5Medarex to Present at the Jefferies Second Annual Healthcare Conference 2
Alexa Fluor 647 anti-mouse Qa-2...
... essential for hunting and analyzing the ... as EST sequencing projects, microarrays, functional ... is developed for normalization of cDNA ... for directional cloning. While most normalization ...
... acquision and analysis software for ... applications. Contains powerful stimulus generation ... functions including automated waveform feature ... includes many electrophysiology specific functions ...
normal human fibroblasts Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: