Navigation Links
DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
Date:8/15/2007

For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding of human biology, such as in stem cell research.

Faithful duplication of the genome (the hereditary information that is encoded in genetic materials known as DNA) ensures that daughter cells inherit a complete set of genetic materials identical to parent cells. This duplication occurs in the section of the cell cycle known as the S-phase. Extensive research on the budding yeast, an organism often used in modern cell biology research, had revealed that the replication process is initiated at hundreds of origins in the S-phase. However, because previous studies focused on the replication timing and initiation sites, but not on the efficiency, it was thought that replication efficiency decreased as the S-phase progressed.

In a paper published in PLoS ONE in August 2007, GIS scientists described how they were able to determine the replication timing and efficiency at the various loci in the genome. Specifically, replication efficiency was found to be low at the beginning of the S-phase, and increased at the later stage of this phase.

GIS Group Leader and the corresponding author of the publication, Dr Liu Jianhua, said, Our evidence strongly supports the stochastic model for the regulation of DNA replication in high eukaryotes (organisms whose cells are organised into complex structures by internal membranes and a cytoskeleton) such as humans. We have shown that replication efficiency can be directly determined on a genomic scale. More significantly, our study provides for a novel methodology for the analysis of replication efficiencies at a genomic level in other species, and this is a very important step for the advancement of research in fundamental biology.


'/>"/>

Contact: Winnie Serah Lim
limcp2@gis.a-star.edu.sg
64-788-013-973-07884
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Unchecked DNA replication drives earliest steps toward cancer
2. Novel mechanism for DNA replication discovered
3. UW scientists unravel critical genetic puzzle for flu virus replication
4. Enzyme inhibitors block replication of SARS virus
5. ANU scientists crack DNA replication mystery
6. U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
7. A first glimpse of the influenza replication machine
8. Common mechanisms for viral DNA replication
9. Crickets finicky mating behavior boosts biodiversity
10. Remote control flies? Fly behavior controlled by laser light
11. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has ... Market in Automotive Sector 2014-2018" report to their ... Recognition market in Automotive Sector to grow at a ... Gesture recognition is the ability of a device to ... Gesture recognition technology can be 2D-based or 3D-based. It ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... closely associated with the African savanna -- fierce lions, ... players when it comes to shaping the ecosystem. ... be the termite, say ecologists who,ve found that these ... Kenya via a network of uniformly distributed colonies. Termite ...
... study finds heterotrophic bacteria counts, in more than 70 ... specified by the United States Pharmacopeia (USP). Researchers ... 110th General Meeting of the American Society for Microbiology ... water a large number of urban Canadians are switching ...
... animals most closely associated with the African savanna -- ... relatively minor players when it comes to shaping the ... to be the termite, say ecologists who,ve found that ... central Kenya via a network of uniformly distributed colonies. ...
Cached Biology News:The star of Africa's savanna ecosystems may be the lowly termite 2The star of Africa's savanna ecosystems may be the lowly termite 3Study finds high level of bacteria in bottled water in Canada 2Lowly termite, not the lion or elephant, may be the star of Africa's savanna 2Lowly termite, not the lion or elephant, may be the star of Africa's savanna 3
(Date:4/1/2015)... -- Goldman Small Cap Research, a stock market research ... announced today that it has issued a new article ... traded clinical stage biotechnology company focused on developing and ... sponsored research article, along with disclosures and disclaimers, or ... www.GoldmanResearch.com .  In the article on ...
(Date:4/1/2015)... , April 1, 2015  EMD Serono, the U.S. ... , announced today the appointment of Frederick ... Neurology and Immunology. In this capacity, he will lead ... development projects and collaborations for Rebif ® (interferon ... pipeline. Dr. Munschauer joins EMD Serono ...
(Date:4/1/2015)... , Mar. 30, 2015 Research and Markets ... addition of the "Blood Screening Market by ... Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting), Product ... - Forecasts to 2019 " report to ... is expected to reach $2.55 billion by 2019 ...
(Date:4/1/2015)... , April 1, 2014 /CNW/ - Canada,s ... Prices Review Board,s (PMPRB) newly released report on Cost Drivers ... Rx&D notes that, according to the report, the rates of ... years, reaching a low of -0.8 percent in 2012/13 for ... that any study that examines the costs of medicines without ...
Breaking Biology Technology:Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 2Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 4EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 2EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 3EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 4EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 5Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 2Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 3Rx&D responds to PMPRB report: overall impact of medicines must always be considered 2
... of our nation,s long-term clean-energy future, but the technology ... Japan,s recent Fukushima disaster. Indeed, many nations have called ... are operating safely. In the United States, ... percent of the electricity from emission-free sources, including renewable ...
... Mediabrands, IPG Media Lab and Affectiva today announced, ... results of the first annual Neuromarketing Awards. Utilizing ... record and measure viewers, tacit, non-verbal response to ... features are established and are then measured and ...
... ,   The randomised, ... efficacy and safety of,the monoclonal antibody rituximab (RTX) ... that in patients with,severe AAV a single course ... period of 18 months proved to be as ...
Cached Biology Technology:Berkeley scientists pioneer nanoscale nuclear materials testing capability 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 3ERA-EDTA Congress 2011: Late Breaking Clinical Trials I 2
... Optimization Kits without ammonium sulfate are compatible ... such as Taq and AmpliThem™™ DNA polymerases. ... PCR systems in one experiment by adding ... into the PreMixes supplied with the kit. ...
... The FailSafe™ PCR System is the ... the first time and every time. It ... regardless of the source or the property ... EPICENTRE's FailSafe™ PCR Enzyme Mix, a unique ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... Designed to meet the needs ... animal component-free medium supports fast ... cell densities, while maintaining high ... protein production using the Baculovirus ...
Biology Products: