Navigation Links
DNA repair patterns may predict risk of pancreatic cancer
Date:1/14/2009

PHILADELPHIA Genetic variations in DNA repair patterns may increase risk of pancreatic cancer by as much as threefold or decrease it by as much as 77 percent, depending on the genes involved, according to a report published in the January 15, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

Pancreatic cancer is often identified in late stages, and thus is resistant to most available therapies. Scientists like Donghui Li, Ph.D., a professor in the Department of Gastrointestinal Medical Oncology at The University of Texas M. D. Anderson Cancer Center, are working to determine genetic profiles that can be used in identifying high-risk individuals for the purpose of prevention and early detection of this disease.

"Our study provides some preliminary data on one pattern of genetic variations that may be useful in determining risk," said Li, who is the lead author on the Clinical Cancer Research paper. "However, we still need to be cautious. As with any science, the key is replication, and the results of this study need to be confirmed by others."

Li and colleagues analyzed nine single nucleotide polymorphisms of seven DNA repair genes among 734 patients with pancreatic cancer and 780 people without cancer. DNA repair is the guardian of the genome. When DNA repair failed to fix the DNA damages caused by exogenous agents such as tobacco carcinogens or endogenous agents such as reactive oxygen species, there is an increased chance of getting cancer.

Researchers found that the presence of a homozygous mutant genotype of LIG3 G-39A was associated with a 77 percent reduction in the risk of pancreatic cancer. By contrast, the presence of the gene ATM D1853N was associated with a nearly threefold (255 percent) increased risk of pancreatic cancer.

Currently, there is no approved genetic screening tool for pancreatic cancer, Li said.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related biology news :

1. Human derived stem cells can repair rat hearts damaged by heart attack
2. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
3. Enzyme alerts cells powerful army to repair DNA damage
4. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
5. Simulation reveals how body repairs balance after damage
6. Using nanotubes to detect and repair cracks in aircraft wings, other structures
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Yale receives $8.4 million to study DNA repair in cancer cells
9. Building the future -- 21st century nano tools to repair the nervous system
10. Researchers probe a DNA repair enzyme
11. Wildcat Power Cord repairs cruciate ligament in dairy cows knee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... , ... June 20, 2017 , ... ... discovery of antibody therapeutics from millions-diverse immune repertoires, announces launch of its new ... Diego, California. Dave Johnson, PhD, CEO of GigaGen, will present on Surge at ...
(Date:6/19/2017)... ... 19, 2017 , ... Tunnell Consulting has been solving the most ... biggest challenges faced by life sciences, biotech and pharmaceuticals companies today is in interpreting ... Abraham , who is well known in the industry and brings significant high-level expertise ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cambridge Semantics ... that its Anzo Smart Data Lake® (Anzo SDL) solution was named a ... 2017 Software & Information Industry Association (SIIA) CODiE Awards. , Finalists represent ...
(Date:6/15/2017)... ... June 15, 2017 , ... Cybrexa Therapeutics, ... B round of financing in the amount of $6 million. An investment vehicle ... in the round. , The Series B funding will enable Cybrexa to complete ...
Breaking Biology Technology: