Navigation Links
DNA repair mechanisms relocate in response to stress
Date:3/26/2009

Like doctors making house calls, some DNA repair enzymes can relocate to the part of the cell that needs their help, a collaborative team of scientists at Emory University School of Medicine has found.

The signal that prompts relocation is oxidative stress, an imbalance of cellular metabolism connected with several human diseases.

The study integrated the expertise of three Emory groups and resulted in a new level of understanding of the cell's response to genetic damage. The finding could lead to new targets for anti-cancer drugs that interfere with DNA repair, says Paul Doetsch, PhD, professor of biochemistry, radiation oncology, and hematology and oncology at Emory University School of Medicine.

The results were published in the February 1 issue of Molecular and Cellular Biology. The journal's editors chose an image of yeast cells with fluorescent DNA repair enzymes for the cover.

"DNA damage and oxidative stress are very closely related," Doetsch says. "For example, the way radiation inflicts most of its damage on DNA is through oxidative stress. The more we know about how cells respond to oxidative stress, the more chances there could be to influence those responses for diagnostic or therapeutic purposes."

The DNA inside cells is continually under assault by heat, radiation and oxygen. Cells have an extensive set of repair enzymes that comb through DNA, continually excising and re-copying damaged segments. To complicate matters, mitochondria (cells' miniature power plants) have their own DNA.

Working with Doetsch, Emory graduate students Lyra Griffiths and Dan Swartzlander, and biochemists Anita Corbett and Keith Wilkinson, genetically modified strains of yeast so that two different DNA repair enzymes would be fluorescent. They were able to follow the enzymes around the cell when yeast was exposed to hydrogen peroxide, causing oxidative stress, or to other chemicals causing DNA damage.

'/>"/>
Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Human derived stem cells can repair rat hearts damaged by heart attack
2. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
3. Enzyme alerts cells powerful army to repair DNA damage
4. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
5. Simulation reveals how body repairs balance after damage
6. Using nanotubes to detect and repair cracks in aircraft wings, other structures
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Yale receives $8.4 million to study DNA repair in cancer cells
9. Building the future -- 21st century nano tools to repair the nervous system
10. Researchers probe a DNA repair enzyme
11. Wildcat Power Cord repairs cruciate ligament in dairy cows knee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... to Wednesday, Oct. 18-22, 2014 , WHERE: ... Drive, San Diego, CA 92101 , WHAT: ... presentations of the latest research in human genetics. ... featuring high-scoring abstracts on rare genetic variants in ... and treatment for sun sensitivity (Saturday, Oct. 18, ...
(Date:8/21/2014)... University have developed a novel and versatile modeling strategy ... creating new materials as well as for studying polyelectrolytes, ... us to model much larger and more complex polyelectrolyte ... Nan Li, lead author of a paper on the ... of Materials Science and Engineering. "This is a big ...
(Date:8/20/2014)... persist in a cold, dark world. A UT microbiology ... waters and sediments from a shallow lake deep beneath ... supports microbial ecosystems. , The National Science Foundation-funded ... for life in other extreme environments, both on Earth ... in the current edition of the science journal ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Researchers develop models to study polyelectrolytes, including DNA and RNA 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2
... As people become more globally mobile, plants can inadvertently get ... not used to hosting them. Such invasions of exotic ... expense of native plants. How weeds and invasive plants ... can manage and control them, are addressed in a newly ...
... of extended wakefulness and low-dose alcohol has significant adverse ... the risk of getting into a vehicular accident, according ... of the journal SLEEP. The study, authored by ... and Sleep in Heidelberg, Victoria, Australia, focused on 19 ...
... decades, pundits have predicted new contraceptives for men within the ... any closer? Judging from work presented today at the ... be yes. But will men actually use a new ... the nonprofit Male Contraception Information Project, says demand is the ...
Cached Biology News:Book on weeds and invasive plants discusses how to manage them using ecological approaches 2Book on weeds and invasive plants discusses how to manage them using ecological approaches 3Extended wakefulness, combined with alcohol, severely impairs driving performance 2Contraception: progress brings hope for new methods for men 2
(Date:8/20/2014)... Grade school history lessons often have it that American ... whooping cough, chicken pox, influenza and tuberculosis brought to ... while estimates vary, about 20 million people lived in ... percent of them were killed by European diseases., But ... Arizona State University and Johannes Krause of the University ...
(Date:8/20/2014)... August 20, 2014 High performance ... apply the most complete climate and Earth system ... climate change issues. , Eight national laboratories, including ... the National Center for Atmospheric Research, four academic ... effort. Other participating national laboratories include Argonne, Brookhaven, ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 The ... is being held on October 29-30 in San ... from industry, academic and government researchers and clinicians focused ... the space. , In the twelve years since ... hundred therapies have been introduced with pharmacogenetic information in ...
(Date:8/20/2014)... could improve the health of your heart, researchers have ... used a standard TENS machine like those designed to ... tragus, the small raised flap at the front of ... , The stimulation changed the influence of the nervous ... that can drive failing hearts too hard. , Professor ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2
... -- a North,American Advisory firm -- has been tapped ... conduct special analyses on China,s continuing,developmental efforts in specific ... on the top-tiered,areas of Beijing, Shanghai, and Tianjin, additional ... project. , (Photo: ...
... DSM,Biologics, a business unit of DSM Pharmaceutical Products, and ... Swiss Exchange:,CRX), today announced that Hungary-based Gedeon Richter Plc. signed ... biopharmaceuticals on the PER.C6(R) platform. , ... , About PER.C6(R) technology ...
... Tengion Inc., a clinical stage regenerative medicine company focused on ... M.D., President and Chief Executive Officer of Tengion, will present at ... 2008 at 9:50 a.m. EST at The Palace Hotel in New ... About Tengion , , ...
Cached Biology Technology:DSM Biologics and Crucell Announce Commercial PER.C6(R) Licensing Agreement with Gedeon Richter 2DSM Biologics and Crucell Announce Commercial PER.C6(R) Licensing Agreement with Gedeon Richter 3DSM Biologics and Crucell Announce Commercial PER.C6(R) Licensing Agreement with Gedeon Richter 4
... OEM-EPC is the smallest electronic pressure ... 60 mm. Parker configured this unit specifically ... OEM markets. Used in carrier gas flow ... liquid dispensing, and hydro-dynamic focusing, the OEM-EPC ...
... (Low Flow) offers the same benefits as the ... where control is critical or flow is required ... the flow of gas in proportion to the ... or pulse width modulation; closed loop feedback delivers ...
...
... is obtained from non-demolished blood ... fasted donors. The donors are ... and are maintained on an ... Protein Concentration : 85 mg/ml ...
Biology Products: