Navigation Links
DNA origami
Date:10/31/2011

In the emerging field of synthetic biology, engineers use biological building blocks, such as snippets of DNA, to construct novel technologies. One of the key challenges in the field is finding a way to quickly and economically synthesize the desired DNA strands. Now scientists from Duke University have fabricated a reusable DNA chip that may help address this problem by acting as a template from which multiple batches of DNA building blocks can be photocopied. The researchers have used the device to create strands of DNA which they then folded into unique nanoscale structures. They will present their findings at the AVS Symposium, held Oct. 30 Nov. 4, in Nashville, Tennessee.

Many different methods of DNA synthesis have been developed, but each method has its drawbacks. Bulk DNA synthesis, which makes use of separate columns to house the reactions, can produce large amounts of material, but is costly and limited in the number of different DNA sequences it can create. The Duke researchers, by contrast, used an inkjet printer head to deposit small droplets of chemicals on top of a plastic chip, gradually constructing DNA strands of mixed length and composition on the surface. The team then used a biological photocopying process to harvest the DNA from the chip. To the researchers' surprise, they found they could reuse the chip to harvest multiple batches of DNA. "We found that we had an "immortal" DNA chip in our hands," says Ishtiaq Saaem, a biomedical engineering researcher at Duke and member of the team. "Essentially, we were able to do the biological copying process to release material off the chip tens of times. The process seems to work even using a chip that we made, used, stored in -20C for a while, and brought out and used again."

After releasing the DNA from the chip, the team "cooked" it together with a piece of long viral DNA. "In the cooking process, the viral DNA is stapled into a desired shape by the smaller chip-derived DNA
'/>"/>

Contact: Catherine Meyers
cmeyers@aip.org
301-209-3088
American Institute of Physics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Caltech scientists control complex nucleation processes using DNA origami seeds
2. Unfolding natures origami
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... undiagnosed, suspected genetic conditions, a certain type of exome ... yield than traditional molecular diagnostic methods, according to a ... being released to coincide with the American Society of ... the protein­coding region of the genome (the complete set ... or organism), has been rapidly applied in research settings ...
(Date:10/16/2014)... body. Battles are won, lost or sometimes end ... as tumor dormancy—can last up to 25 years ... poorly understood. , A new computational model ... Professor of Chemistry at Princeton University, may help ... switch to a malignant state. Published today in ...
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
Breaking Biology News(10 mins):Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Modeling tumor dormancy 2New perspectives for development of an RSV vaccine 2
... 3, 2010 Genes interact in complex networks that govern ... relationships. Researchers are now discovering how biological networks change ... today in Genome Research ( www.genome.org ), scientists ... light on how interactions go awry in disease. MicroRNAs ...
... Researchers from the University of Leeds, UK, the ... for Molecular Medicine (MDC) in Berlin, Germany, have ... Their studies have identified how ,junk, DNA promotes the ... Professor Constanze Bonifer (University of Leeds) and Dr Stephan ...
... oil could help prevent ulcerative colitis, according to a new ... Anglia (UEA). Presented today at the Digestive Disease ... with a diet rich in oleic acid which is ... ulcerative colitis. Oleic acid is a monounsaturated fatty acid found ...
Cached Biology News:MicroRNA network study implicates rewired interactions in cancer 2'Junk DNA' drives cancer growth 2Olive oil could guard against developing ulcerative colitis 2
(Date:10/25/2014)... , October 24, 2014 ... Markets ( http://www.researchandmarkets.com/research/t5t5pd/the_global_market ) has announced the addition ... Nanotubes, Graphene And Other 2-D Nanomaterials " ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,CNTs and graphene are ... known to man, with a performance-per-weight greater ...
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... and Rhythm, a biopharmaceutical company, today announced that Actavis ... wholly owned subsidiary, Rhythm Health, Inc., which is developing ... of diabetic gastroparesis and other GI functional disorders. ... trial of relamorelin for the treatment of diabetic gastroparesis ...
(Date:10/22/2014)... Md. (PRWEB) October 21, 2014 Shimadzu ... an LC/MS/MS data tool for the pain management and ... of data processing and review by allowing users to ... to clinicians. , QuantAnalytics allows analysts to filter ... This expedites data processing by eliminating the need to ...
(Date:10/22/2014)... 22, 2014 Currently offering a ... & D Weighing, Rice Lake, and Ohaus, Pipette.com ... . The Sartorius CPA Semi-Micro Balance is ideal ... precise, and user-friendly laboratory balance. , Sartorius is ... their laboratory balances are well known for their ...
Breaking Biology Technology:The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3
... at the National Institute of Standards and Technology (NIST) ... viscosity measurementscritical data for a wide variety of fields ... as small as a few nanoliters. Currently a table-top ... tool for biotechnologists studying minute quantities of complex materials ...
... Mr. Robert Nealon reports: IGEN Networks Corp. ... Standard and Poor,s ("S&P") has approved IGEN for their ... Records is considered the premier source for information on ... professionals. As part of the approval, IGEN,s corporate profile ...
... of Services in Neuronal Research Using Human iPS... -- YOKOHAMA, Japan, September 1, 2010 ... ... --> ... var s = ,; var first_result; // Results are keyed by longUrl, so we need to grab ...
Cached Biology Technology:Micro rheometer is latest Lab On a Chip device 2IGEN Networks Corp. obtains Blue Sky Statutory Compliance in 38 States with Approval of Standard & Poor's 2ReproCELL Announces New Line of Services in Neuronal Research Using Human iPS Cells 2ReproCELL Announces New Line of Services in Neuronal Research Using Human iPS Cells 3ReproCELL Announces New Line of Services in Neuronal Research Using Human iPS Cells 4ReproCELL Announces New Line of Services in Neuronal Research Using Human iPS Cells 5ReproCELL Announces New Line of Services in Neuronal Research Using Human iPS Cells 6
... Maximize the value of your ... We offer the support you need ... using the most up to date ... with the Gene Expression Profiling Service ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
Formula variant: With macro- and micronutrients. Physical Form: powder Suitab tst: plant cell culture tested...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ...
Biology Products: