Navigation Links
DNA mutations linked to diabetes
Date:9/2/2009

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institutet published in Cell Metabolism. The researchers believe that these 'epigenetic mutations' might have a key part to play in the development of the disease.

Type II diabetes is characterised by a lower sensitivity to insulin in muscles and organs, and a reduced ability to consume energy in the form of glucose. Heredity and environmental factors (e.g. exercise) are both involved in the disease pathogenesis, but scientists are still unclear as to the mechanisms behind it.

A research group at Karolinska Institutet has now shown that genes in the muscle cells of diabetics are chemically modified through what is known as DNA methylation. They found that in muscles cells taken from patients with early-onset diabetes, a gene designated as PGC-1α was modified and had reduced expression. PGC-1α controls other genes that regulate the metabolism of glucose by the cell.

The team has also demonstrated that DNA methylation occurs rapidly, when cells from healthy people are exposed to certain factors associated with diabetes, such as raised levels of free fatty acids and cytokines. DNA methylation is a form of epigenetic regulation, a process involving chemical modifications that are imposed externally on genes and that alter their activity without any change to the underlying DNA sequence.

"This type of epigenetic modification might be the link that explains how environmental factors have a long-term influence on the development of type II diabetes," says Juleen Zierath, who led the study. "It remains to be seen whether the DNA methylation of this gene can be affected by, say, dietary factors."


'/>"/>

Contact: KI Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1

Related biology news :

1. New study reveals for first time how BRCA1 mutations cause breast cancer
2. Should children be permitted to get genetic testing for BRCA 1/2 mutations?
3. CSHL scientists part of team that discovers role of rare gene mutations in schizophrenia
4. Rare genetic mutations protect against hypertension
5. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
6. Oocyte-specific gene mutations cause premature ovarian failure
7. Smothered genes combine with mutations to yield poor outcome in cancer patients
8. How hidden mutations contribute to HIV drug resistance
9. Large reservoir of mitochondrial DNA mutations identified in humans
10. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
11. Researchers discover gene mutations that cause childhood brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2016)... According to the new market research report "Biometric System Market ... Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), Application, and Region ... to grow from USD 10.74 Billion in 2015 to reach USD 32.73 ... Continue Reading ... ...
(Date:11/17/2016)... Nov. 17, 2016  AIC announces that it has just released a new white ... require high-performance scale-out plus high speed data transfer storage solutions. Photo - ... ... ... Setting up a high performance computing or ...
(Date:11/14/2016)... SANTA CLARA, Calif. , Nov. 14, ... of the biometric identification market, Frost & ... Global Frost & Sullivan Award for Visionary ... leading player in the biometric identification market ... a multi-modal verification solution for instant, seamless, ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... Conn. , Dec. 2, 2016  The Multiple ... presentations from the MMRF CoMMpass Study SM —the largest ... accelerating precision medicine in multiple myeloma—will be presented at ... Annual Meeting & Exposition in San Diego ... helping to optimize treatment strategies, as well as identify ...
(Date:12/2/2016)... , Dec 2, 2016 Research ... report "Nanobiotechnology Applications, Markets and Companies" to their ... , , ... nanobiotechnology by the pharmaceutical and biotechnology industries is anticipated. Nanotechnology ... from formulations for optimal delivery to diagnostic applications in clinical ...
(Date:12/2/2016)... ... December 01, 2016 , ... Aerocom Healthcare ( http://www.aerocomhealthcare.com ), ... present its chain-of-custody solution for tracking and securing medications at booth 676 at ... 2016. , Aerocom has a proven solution for tracking medications via its system ...
(Date:12/2/2016)... OF PRUSSIA, PA (PRWEB) , ... December 01, 2016 , ... ... research is through industry-wide collaboration, standardization and a beautiful technology experience. All three tenets ... convened more than 100 clinical trial leaders from over 40 sponsor, CRO and site ...
Breaking Biology Technology: