Navigation Links
DNA methylation shown to promote development of colon tumors
Date:11/30/2007

determine the impact of inducing methylation on tumor development," says Linhart. "Does it inhibit it, do nothing or promote it""

Surprisingly and importantly, methylation appears to target specific regions of the DNA and the genes within them rather than being distributed randomly. "We found that key tumor-suppressor genes in certain DNA regions were silenced months before tumors appear," says Linhart. This specific targeting extends to organs as well: A given gene that is methylated in the colon, for example, does not become methylated in the spleen. The specificity of the process could prove a major advantage for diagnostic and therapeutic approaches based on DNA methylation.

"The enzymes that silence tumor-suppressing genes would be terrific targets for treatment," says senior author Rudolf Jaenisch. "If we can inactivate them and rescue the cancer-prevention functions of these genes, there would be predictably no side effects. And if we can examine circulating blood for signs of early methylation, we might be able to prevent tumors from developing."

Although this study focused on mice, Jaenisch notes that current clinical trials using a drug to inhibit methylation in people with leukemia appear to delay the disease."


'/>"/>

Contact: Eric Bender
bender@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Spaceflight shown to alter ability of bacteria to cause disease
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Regulation of TATA-less promoters
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. Gender, coupled with diabetes, affects vascular disease development
6. New target for anti-flu drug development
7. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
8. KAUST and American University in Cairo to collaborate on research and academic development
9. Old developmental pathways spawn revolutionary evolutionary changes
10. NIST announces 56 new awards for innovative technology research and development
11. Progress Against Malaria: Developments on the Horizon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... CHICAGO , Jan. 9, 2015 Valid S.A. ("Company") ... the market in general the State of Washington,s ... contract for a new enrollment and central issuance system for ... The project planning and development will start ...
(Date:1/22/2015)... Jan. 16, 2015  A man-made form of insulin delivered ... mental capabilities in adults with mild cognitive impairment and ... by researchers at Wake Forest Baptist Medical Center. ... amnesic mild cognitive impairment (MCI) or mild to moderate ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... , This release is available in ... of Agriculture (USDA) scientists and cooperators provides new details ... antibacterial agent in soaps and other cleaning suppliesinto the ... as treated wastewater solids, to their fields as a ...
... X-rays are the medium of choice for many scientific ... shed light on the material,s structure, providing loads of information ... the sample has to be in a vacuum for the ... liquids, that means you have to remove all the water. ...
... Each year, thousands of acres of crops are planted throughout ... by a parasitic plant called Striga, also known as witchweed. ... security in Africa, and a team of scientists led by ... genes that may break Striga,s stranglehold. When crops grow, ...
Cached Biology News:Tracking triclosan's field footprint 2LiXEdrom: Innovative measuring chamber for X-ray study of liquid jets 2
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to ... independent consultants, Protocol Networks has recently announced its expansion ... years, his company has attracted several clients in The ... well as others. With the success of these engagements, ...
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... L.J. Star , Inc., a major supplier ... it has a suite of solutions for the special demands of process ... , , ... monitor fluid flows, and thereby help maintain strict control of critical processes. ...
... soon be able to surf in colder waters and ... Laboratory (NPL) and UK wetsuit manufacturer, Spartan. Spartan ... approached NPL, the UK,s measurement institute, to understand the ... its product design. In particular it wanted to improve ...
... AMSTERDAM , May 19, 2010 ... field of human gene,therapy, today provides its non-audited business update in ... financial position for the first quarter of 2010. , , ... formal review of Glybera(R) dossier, - Dossier validated ...
Cached Biology Technology:L.J. Star Announces Stainless Sanitary Fittings, Sight Glasses and Sight Flow Indicators for the Special Demands of the Pharmaceutical Industry 2L.J. Star Announces Stainless Sanitary Fittings, Sight Glasses and Sight Flow Indicators for the Special Demands of the Pharmaceutical Industry 3L.J. Star Announces Stainless Sanitary Fittings, Sight Glasses and Sight Flow Indicators for the Special Demands of the Pharmaceutical Industry 4A warmer future for watersports 2AMT Provides Business Update for the First Quarter 2010 2AMT Provides Business Update for the First Quarter 2010 3
Candida (IgA) -Ab EIA Sample Size: 5 l...
... cell lines in combination with the ... parameters. Nucleofector Kits are only functional ... Different cell lines can be transfected ... and viabilities are given in brackets ...
...
Request Info...
Biology Products: