Navigation Links
DNA methylation shown to promote development of colon tumors
Date:11/30/2007

and genetic regions, depending on what each cell needs to do. Since almost every cell of an organism has the identical DNA sequence the "packaging" of this DNA by these epigenetic mechanisms is a key element in determining cell identity and helps generate the wide variety of cell types that are found in the human body.

"If we tried to read a book that had the letters arranged in rows, we could not understand it," says Linhart. "We not only need the letters arranged in sequence, we need spaces and formatting to separate the letters into words, sentences and paragraphs. In the same way, we can imagine the human genome as a list of letters printed one after the other, without spaces or formatting. Methylation and protein packaging of DNA help the cell 'read' and make sense of the DNA sequence, determining which genes need to be active to perform a particular function, and which ones need to be switched off."

As cells renew and divide, their characteristic methylation and packaging pattern is usually maintained and transmitted to the new cells, ensuring that recently formed heart cells, for example, carry the same correct instructions for how to behave in order to contract and pump blood.

Trouble arises, however, when there is either too little methylation throughout the DNA (hypomethylation) or too much on specific regions of the strand (hypermethylation)both of which are frequently observed in cancer. In the last decade, scientists at Whitehead Institute and elsewhere demonstrated that the first phenomenontoo little methylation throughout the genomeis causally associated with the development of cancer.

The most recent Whitehead study established a direct causal connection between the second form of methylation imbalanceregional increases in methylationand the development of colon tumors. The scientists did this by giving mice prone to developing intestinal tumors four variations of an enzyme that causes methylation. "We wanted to
'/>"/>

Contact: Eric Bender
bender@wi.mit.edu
617-258-9183
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Spaceflight shown to alter ability of bacteria to cause disease
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Regulation of TATA-less promoters
4. Synthetic compound promotes death of lung-cancer cells, tumors
5. Gender, coupled with diabetes, affects vascular disease development
6. New target for anti-flu drug development
7. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
8. KAUST and American University in Cairo to collaborate on research and academic development
9. Old developmental pathways spawn revolutionary evolutionary changes
10. NIST announces 56 new awards for innovative technology research and development
11. Progress Against Malaria: Developments on the Horizon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 1, 2014, 10:20 AM EDT) It may be ... foods over unhealthy higher-calorie foods, according to new research ... Research Center on Aging (USDA HNRCA) at Tufts University ... the journal Nutrition & Diabetes , a brain ... it is possible to reverse the addictive power of ...
(Date:9/1/2014)... ago, electron microscopy revealed the presence of tiny blob-like ... But scientists still don,t know what they do ... believed to be crucial to the life of a ... disease treatment., In the Journal of Cell Biology ... from various backgrounds, from biophysics to cell biology, to ...
(Date:9/1/2014)... Section of the XVIII International Botanical Congress took place ... held every six years and it is where the ... fungi and plants get together to debate and update ... This is the primary product of the meeting, the ... which was published in 2012. The other important product ...
Breaking Biology News(10 mins):Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2
... Works to Strengthen Security for Anyone with ... Sept. 17 Today a,Southwest Airlines pilot ... be screened by,the Transportation Security Administration (TSA) ... demonstration project called,SecureScreen will utilize biometrics to ...
... $24 million in federal funding to establish the University ... CEIN), which will help researchers design safer and more ... to be housed at the California NanoSystems Institute (CNSI) ... nanomaterials on life forms and the interactions of these ...
... Foundation (NSF) and the Environmental Protection Agency (EPA) have ... Implications of NanoTechnology (CEINT) to explore the potential ecological ... as a million times smaller than the head of ... objects made from the same material. These unusual properties ...
Cached Biology News:Southwest Pilots Launch TSA Demonstration Project to Test Biometric Screening 2UCLA, partners establish new center on environmental effects of nanotechnology 2UCLA, partners establish new center on environmental effects of nanotechnology 3UCLA, partners establish new center on environmental effects of nanotechnology 4Duke to lead new NSF, EPA center to study the environmental implications of nanotechnology 2Duke to lead new NSF, EPA center to study the environmental implications of nanotechnology 3
(Date:8/28/2014)... 28, 2014  Next month, executives from clinical trial marketing ... events beginning with Patient-Centered Clinical Trials 2014 , to ... Boston , September 4-5. Patient recruitment experts Bonnie ... Fleishman will share insights on the benefits of employing ... tactics – from media to mobile apps – can be ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
(Date:8/28/2014)... Exciting new work by a Florida State University research ... can take your temperature, emit white light, and convert ... molecule looks like a butterfly. , Biwu Ma, associate ... in the FAMU-FSU College of Engineering, created the molecule ... continued to discover that his creation has many other ...
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3
... 29 Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ... and commercializing proprietary product candidates principally,for use ... the company,s,President and CEO Theodore Schroeder will ... 6 at 1:30pm Eastern Time (10:30am Pacific ...
... U.S. Attorney,s, Office for Eastern District of Pennsylvania and ... Settles State Cases with Connecticut and ... (Nasdaq:,CEPH) announced today it has finalized a previously announced ... Eastern District of,Pennsylvania, the U.S. Department of Justice and ...
... Calif., Sept. 29 Poniard,Pharmaceuticals, Inc. (Nasdaq: PARD ... Jerry McMahon, Ph.D., chairman and CEO,will present at the ... 9 a.m. Eastern Time at Le Parker Meridien in ... overview, including a discussion,of the development of picoplatin, the ...
Cached Biology Technology:Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at the JMP Securities Third Annual Healthcare Focus Conference 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 3Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 4Poniard Pharmaceuticals to Present at the JMP Securities Healthcare Focus Conference 2
Whole blood is collected from healthy pigs (mixed breed, either sex) at the time of slaughter, refrigerated within 6 hours, processed within 24 hours and frozen at -20ºC....
ANTI S. ENT TOX BC2D...
Human/Mouse/Rat Keap1 MAb (Clone 333116) Protein Family: Transcription Factor Regulators...
Reacts with MBP from human, bovine and rat, epitope 129-138. Reacts weakly with rabbit. Does not react with guinea pig....
Biology Products: