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DNA-linked nanoparticles form switchable 'thin films' on a liquid surface
Date:6/11/2014

of the nanoscale size-regime, we might envision using such membranes for filtering proteins or other nanoparticles," he said.

Understanding how synthetic DNA-coated nanoparticles interact with a lipid surface may also offer insight into how such particles coated with actual genes might interact with cell membraneswhich are largely composed of lipidsand with one another in a lipid environment.

"Other groups have considered using DNA-coated nanoparticles to detect genes within cells, or even for delivering genes to cells for gene therapy and such approaches," said Gang. "Our study is the first of its kind to look at the structural aspects of DNA-particle/lipid interface directly using x-ray scattering. I believe this approach has significant value as a platform for more detailed investigations of realistic systems important for these new biomedical applications of DNA-nanoparticle pairings," Gang said.


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Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert  

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