Navigation Links
DNA fingerprinting pioneer discovers role of key genetic catalyst for human diversity
Date:9/5/2010

s."

Ironically, the variation in PRDM9 is due to a minisatellite within the gene itself. Sir Alec said: 'I've come full circle starting out with minisatellites to develop DNA fingerprinting, and arriving at a gene containing a minisatellite that plays a key role in driving all kinds of human DNA diversity, including variation at minisatellites. An intriguing possibility is that it is even driving its own evolution!'

Sir Alec believes the research, along with that of others working in the field, will inevitably further scientists' ability to understand the basic processes that make us all genetically unique, as well as defining an entirely new class of genetic risk factor for numerous disease-causing DNA rearrangements that can arise when recombination goes wrong.

These findings also provide a neat solution to one great puzzle of recombination hotspots namely that they appear and disappear rapidly during evolution. Sir Alec said 'We've shown that hotspots have a strange propensity for self-destruction, so how can they possibly exist? The PRDM9 minisatellite gives the answer it evolves rapidly, like any other unstable minisatellite, and keeps churning out variants that can trigger new hotspots, replenishing those that have committed suicide. A totally crazy mechanism to ensure that recombination keeps going, but typical of the weird solutions that evolution can throw up'.


'/>"/>

Contact: University of Leicester press office
pressoffice@le.ac.uk
01-162-523-335
University of Leicester
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Fingerprinting method reveals fate of mercury in Arctic snow
2. Mind reading, brain fingerprinting and the law
3. New advance in revolutionary bullet fingerprinting technique
4. truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children
5. truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children
6. Fingerprinting method tracks mercury emissions from coal
7. Kount Receives Patent for Device Fingerprinting
8. UTHealth neuroscientist wins prominent NIH Directors Pioneer Award
9. 23rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress
10. Educational pioneer BioEYES goes Down Under
11. Case Western Reserve geneticist receives prestigious NIH Directors Pioneer Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA fingerprinting pioneer discovers role of key genetic catalyst for human diversity
(Date:7/11/2014)... is evidence that under the normal circumstances, ... development, maintain neuronal environment, and exhibit therapeutic ... neurodegenerative disease. Previous studies have found that ... after chemical induction have reduced viability, which ... Prof. Xiaodong Yuan, Kailuan General Hospital, Hebei ...
(Date:7/11/2014)... the proteins that let nerve cells send out electrical ... a biological tactic that may offer a new way ... and environmentally responsible way. , Their findingthat naturally ... and harmless for a closely related onesuggests that insecticides ... beneficial species like bees. A summary of the research, ...
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... rehabilitation sooner following knee arthroplasty surgery could pay dividends ... within 24 hours of surgery can improve pain, range ... cut hospital stays, according to new research in the ... Mindful of the trend towards discharging patients from hospital ...
... 6, 2011) -- New findings from researchers at Harvard Medical ... Toronto may shed light on the mechanisms that regulate the ... of cell signaling not well understood at this time. ... protein CD36, a clustering-responsive class B scavenger receptor, as a ...
... from an early warning system developed in part by ... across the U.S. from the threats of insects, disease ... the multi-agency project uses high-performance computing to incorporate remote ... and weather data to identify abnormal vegetation patterns and ...
Cached Biology News:Rehabilitation within a day of knee replacement pays off 2
(Date:7/10/2014)... , July 10, 2014 ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique ... MabNext project BIOCAD develops a number of innovative drugs ... autoimmune diseases. The ceremony took place at the International ...
(Date:7/10/2014)... D.C., April 15, 2014 -- According to the ... to nuclear security comes from terrorists acquiring sufficient ... to construct a crude nuclear explosive device. The ... nuclear trafficking have involved gram-level quantities, which can ... , According to a new study appearing this ...
(Date:7/10/2014)... researchers have observed the fractional quantum Hall effect in ... matter can be tuned by an electric field. ... when electrons confined to thin sheets are exposed to ... behavior where thousands of individual electrons behave as a ... effect is well established, many details of this collective ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... Biosciences , a biopharmaceutical company developing cancer therapies, has ... has been selected for preclinical testing and human clinical ... preclinical safety assessment, it would submit to the ... drug application in late 2007, with human clinical trials ...
... the word sustainability in a crowd of business executives ... you as an aging hippie, then scrambled away to ... , ,Today, sustainability still carries some linguistic baggage, but ... because there's no avoiding a rational conversation. Global climate ...
... we read high-profile stories about personally identifiable information being ... computer network. This sensitive information is being misplaced or ... little accountability for such security breaches. , ,So ... the Wisconsin Legislature and Gov. Jim ...
Cached Biology Technology:Re-engineering our economy to be sustainable and profitable 2Re-engineering our economy to be sustainable and profitable 3Re-engineering our economy to be sustainable and profitable 4Wisconsin identity theft law: A cheap plastic sword 2Wisconsin identity theft law: A cheap plastic sword 3
Functionally tested for consistent G-banding of chromosomes....
... The SilverQuest Silver Staining Kit ... silver staining sensitivity with minimal protein ... The mass spectrometry problems associated with ... the SilverQuest kit because the reagents ...
...
... Medium is formuatled for the growth ... and Sf21 cells. Grace's Insect Mediu, ... it does not contain lactalbumin hydrosylate, ... transfection. Grace's Insect Medium, Supplemented is ...
Biology Products: