Navigation Links
DNA discovery opens new door to develop tools, therapies for hereditary cancers
Date:7/8/2010

l as very aggressive brain tumours.

"The reason why it can lead to cancer is because if you don't have mismatch repair proteins that correct these errors, you're going to accumulate mutations," said Guarn. "People with defective mismatch repair genes develop cancers at very early ages. You would see a family that in their 30s has colorectal cancer and in their 40s they have it again. There's no way you can prevent that you can't correct your DNA. As you grow older, you're going to accumulate mutations."

To determine how MutL is regulated, the researchers characterized the functional and structural domain of the protein that is involved in DNA mismatch repair. By mapping out MutL, they were able to unveil how the replication machinery turns MutL into an enzyme that cuts the error from the DNA. They also discovered that PCNA, another protein within the pathway, allows DNA to bind to MutL so it can be repaired.

"This is especially important because we've known for more than a decade that the PCNA protein is necessary to correct mismatches, but we didn't know its concrete function," Guarn said. "We're starting to understand that one of the roles of these replication proteins is to license the cutting activity of MutL."

The findings have profound implications in understanding the molecular mechanisms that predispose to cancer and Turcot syndrome development. In particular, it allows scientists to pinpoint mutations on the MutL protein in order to determine severity and long-term outcomes.

The results also provide new avenues to develop alternative cancer treatments, as the hope is future cancer therapies may be focused at the molecular level and involve blocking specific pathways within the cell.


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
2. Discovery of how coral reefs adapt to global warming could aid reef restoration
3. Discovery of controlled swarm in bacteria
4. Molecular discovery suggests new strategy to fight cancer drug resistance
5. New discovery could aid development of elusive bovine mastitis vaccine
6. Medical researchers discovery may explain how certain cancers develop
7. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
8. Discovery: Yeast make plant hormone that speeds infection
9. Discovery of stem cell illuminates human brain evolution, points to therapies
10. Covance Establishes New Discovery & Translational Services Group
11. Parallel brainstem circuit discovery suggests new path in Parkinsons research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... their entire lives nestling in the protective tentacles of ... they sometimes travel hundreds of kilometres across the open ... fish has been predicted, this is the first time ... populations has been observed. , Dr Steve Simpson, Senior ... University of Exeter, and colleagues from the Australian Research ...
(Date:9/17/2014)... UCLA atmospheric scientists were instrumental in the creation of ... tool to classify the fire threat potential of the ... a spark into an inferno. The index was introduced ... with UCLA and San Diego Gas and Electric. , ... to "extreme" that will be used to help fire ...
(Date:9/17/2014)... engineering professor and his doctoral student have designed a ... water collected from fog and dew., The device could ... deserts around the globe., Cheng Luo, professor in the ... candidate in the same College of Engineering department, published ... of ACS, (American Chemical Society) Applied Materials ...
Breaking Biology News(10 mins):Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2
... viable future biofuel especially if harvested in summer. ... could provide an important alternative to terrestrial grown biofuels; ... a seasonal basis. Harvesting the kelp in July when ... sugar release for biofuel production. , "The storage carbohydrate ...
... the RIKEN Brain Science Institute (BSI) and their ... a little-studied amyloid peptide in promoting Alzheimer,s disease ... is more abundant, more neurotoxic, and exhibits a ... in earlier research, suggesting a potential role in ...
... which could have practical applications for the medical industry. ... self-cleaning sticky surfaces, which could be useful for a ... medical bandages, tyre performance, and even long lasting adhesives," ... who will be presenting this work at the Society ...
Cached Biology News:Biofuels from the sea 2Overlooked peptide reveals clues to causes of Alzheimer's disease 2Frog feet could solve a sticky problem 2
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest ... for National Lab Day on the Hill. The event ... laboratory system. Durbin and Risch also formally launched the ... of the reach of the national labs as leaders ... some of our nation's most pressing challenges. , "The ...
(Date:9/18/2014)... -- Research and Markets has announced the ... 2014" report to their offering. ... professional and in-depth study on the current state of ... provides a basic overview of the industry including definitions, ... market analysis is provided for the international markets including ...
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)... , Sept. 18, 2014 /PRNewswire/ - Oncothyreon Inc. ... of previously announced concurrent but separate underwritten offerings of ... to the public of $2.00 per share, for expected ... its Series A Convertible Preferred Stock at a price ... gross proceeds of $20 million. Each share of Series ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... the world,s most powerful supercomputers, scientists at Lawrence ... are a good match for the future development ... potential for green energy production because of their ... performed on "Franklin," a Cray XT4 massively parallel ...
... ... Produce Fuels Directly from Cellulosic Biomass , ... South San Francisco, CA (PRWEB) January 27, 2010 -- ... ability to make cellulosic-derived advanced biofuels. A collaborative team of researchers from LS9, ...
... ... Sudek , Chairman of Tech Coast Angels (TCA), the nation,s ... 2010 program of increased entrepreneur support, communication and mentoring will be overseen ... today,s constrained economy, entrepreneurs need easier access to viable sources of help ...
Cached Biology Technology:Mismatched alloys are a good match for thermoelectrics 2Mismatched alloys are a good match for thermoelectrics 3LS9, Inc., U.C Berkeley, and JBEI Make Major Breakthrough in Cellulosic Fuels Production 2LS9, Inc., U.C Berkeley, and JBEI Make Major Breakthrough in Cellulosic Fuels Production 3LS9, Inc., U.C Berkeley, and JBEI Make Major Breakthrough in Cellulosic Fuels Production 4Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 2Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 3Sudek of Tech Coast Angels Announces Network's Increased Commitment to Entrepreneurship and Innovation Through New Easy-Access Programs 4
Goat polyclonal to Nebraska Calf Diarrhea Virus (FITC) ( Abpromise for all tested applications). Antigen: Bovine (Nebraska Calf Diarrhea Virus)....
DNA fragmentation factor & Inhibitor of CAD...
Rabbit polyclonal to Methionine Aminopeptidase 2 ( Abpromise for all tested applications). entrezGeneID: 10988 SwissProtID: P50579...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Biology Products: