Navigation Links
DNA component can stimulate and suppress the immune response
Date:1/27/2009

AUGUSTA, Ga. A component of DNA that can both stimulate and suppress the immune system, depending on the dosage, may hold hope for treating cancer and infection, Medical College of Georgia researchers say.

Low levels of CpG increase inflammation, part of the body's way of eliminating invaders. But high doses block inflammation by increasing expression of the enzyme indoleamine 2,3 dioxygenase, or IDO, an immunosuppressor, the researchers say.

"The same therapy can have two different effects," says Rusty Johnson, a fifth-year M.D./Ph.D. student in the MCG Schools of Medicine and Graduate Studies. "It was assumed that giving this treatment at higher doses would cause more stimulation, but it has the opposite effect."

The researchers hope that manipulating the dosage can help them optimize the role of inflammation in fighting invaders such as tumors and harmful bacteria. Mr. Johnson presented the findings at the Midwinter Conference of Immunologists this month in Asilomar, Calif. He is working with Drs. Andrew Mellor and David Munn, co-directors of the School of Medicine Immuno Discovery Institute, who discovered IDO's immunosuppressive capabilities more than a decade ago.

With the help of Drs. Babak Baban and Phillip Chandler, scientists in MCG's Immunotherapy Center, they've also learned IDO inhibits inflammation by blocking production of interleukin 6, a secreted factor that causes inflammation.

"This suggests that IDO is a counter-regulatory mechanism that serves as a balance to prevent too much inflammation," Mr. Johnson says. "Too much inflammation leads to destruction of normal body tissue, and this shows IDO's importance in preventing this from occurring."

The researchers already knew that IDO protects tumors from the immune system. While working with collaborators Drs. Alex Muller and George Prendergast at the Lankenau Institute in Philadelphia, they learned its role in tumor formation.

"Without it, a mouse becomes resistant to skin tumor formation, and tumors that do form are smaller and less malignant," Mr. Johnson says.

They've also learned that the cells IDO uses to suppress the immune system IDO-competent dendritic cells originate from B cells, which produce antibodies to fight infection.


'/>"/>

Contact: Amy Connell
aconnell@mcg.edu
706-721-8605
Medical College of Georgia
Source:Eurekalert

Related biology news :

1. Scripps research scientists identify blood component that turns bacteria virulent
2. Obscure fungus produces diesel fuel components
3. Key component of debilitating lung disease identified
4. New robot scouts best locations for components of undersea lab
5. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
6. Dissecting the genetic components of adaptation of E. coli to the mouse gut
7. Studying component parts of living cells with carbon nanotube cellular probes
8. A new milestone in the GMES Space Component Program successfully achieved
9. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
10. TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims
11. Mammals can be stimulated to regrow damaged inner retina nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2020)... ... April 28, 2020 , ... Ever a responsive ... in providing timely and critical information to life science organizations as they navigate ... safety concerns. , “Providing the most up-to-date actionable guidance and information has been ...
(Date:4/26/2020)... ... April 23, 2020 , ... A team of researchers ... developing a synthetic antibody to SARS-CoV-2, the virus that causes coronavirus disease (COVID-19). This ... be another potential treatment option for COVID-19. , The efforts are being led by ...
(Date:4/22/2020)... ... April 21, 2020 , ... ... and innovation in technology and compliance, announces a new managed service to improve ... of alliances – Box, ComplianceQuest, and USDM Life Sciences (USDM) – Unify Compliance ...
Breaking Biology News(10 mins):
(Date:3/27/2020)... ... March 26, 2020 , ... iFirst Medical Technologies, Inc., a leader in handheld ... test. , "COVID-19 poses a grave danger to public health here in the U.S. ... compelled to act. Broad-based testing and on-the-spot results promise to slow the spread and ...
(Date:3/19/2020)... ... March 18, 2020 , ... ... bio signals to provide rapid insight into their perceptions of events. Imagine if ... the other. What if they could measure the level of engagement of each ...
(Date:3/12/2020)... ... March 12, 2020 , ... With the beginning of ... the business investment in Europe by inaugurating a new scientific facility for academic ... the new Nanoscience Center Europe took place Tuesday, February 18, 2020, gathering customers, ...
(Date:3/10/2020)... ... March 10, 2020 , ... ... engineering firm, is pleased to announce the addition of Carson Dickey to ... qualification and validation in the biopharmaceutical cold chain. He provides design and ...
Breaking Biology Technology: