Navigation Links
DNA catalysts do the work of protein enzymes
Date:3/19/2013

ating that DNA can catalyze such difficult reactions is an important step forward in designing and using DNA catalysts.

"At this point, this is basic science. We're trying to figure out, what kind of reactions can DNA catalyze? And how do we find DNA catalysts that can catalyze these reactions?" Silverman said.

To find the DNA catalysts that can perform a phosphatase reaction, the researchers used a process called in vitro selection. This method searches through vast numbers of DNA sequences to identify the few that could perform a specific activity. The researchers then synthesize those DNA strands and use them for various applications.

"We believe that DNA catalysts can be a very useful tool in the future to study these kinds of protein modifications," said graduate student and co-author Jagadeeswaran Chandrasekar. "To have DNA that you can synthesize on a machine and do catalytic activity on large molecules like proteins is very exciting. We can make fresh new DNA sequences, without requiring a natural starting point, and perform important reactions."

The researchers tested their DNA catalysts' activity in the presence of other large, non-specific proteins, to find out if they would function in an environment resembling the cell. The DNA catalysts were not bothered by the extra company, giving the researchers hope that one day their DNA catalysts could be used for practical applications in vivo.

Next, the researchers will continue to refine the in vitro selection process and hope to identify more DNA catalysts, designing and building molecules to perform specific functions.

"This kind of finding is enabling because it shows that DNA catalysis of biologically interesting processes is possible," Silverman said, "and with this outcome we can have confidence that the broader objectives of this kind of research are likely to be achievable."


'/>"/>

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2

Related biology news :

1. KIT: Processes at the surface of catalysts
2. Painting with catalysts: Nano-engineered materials for detoxifying water by use of sunlight
3. Catalysts that produce green fuel
4. IU biologists offer clearer picture of how protein machine systems tweak gene expression
5. Making memories: How 1 protein does it
6. Embryonic development protein active in cancer growth
7. More effective method of imaging proteins
8. The loss of a protein makes jump the tumor to the lymph node
9. Gold nanoantennas detect proteins
10. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
11. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
DNA catalysts do the work of protein enzymes
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
(Date:4/14/2015)... OXFORD, Conn. , April 14, 2015 ... "Company"), a biometric authentication company focused on the growing ... has been nominated for the 2015 New York Design ... The Design100, New York City Design Awards are ... are based on over 2,500 ratings from the marketplace, ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Rome, Italy: Researchers in The Netherlands believe they ... blood test that would be able to detect accurately ... only reliable way to do this is through amniocentesis ... and carry the risk of triggering a miscarriage. ...
... the 20th century decline in the Irish hare population ... The Stormont Assembly voted to ban hare coursing ... recent study, funded by the Northern Ireland Environment Agency ... Conservation , suggests hares may join the ranks of ...
... can a tree grow? Does sunlight or water limit the ... growth really determine the height of a tree? These are ... eager to answer as she and her colleagues dangled from an ... above the ground. Most trees, and many other ...
Cached Biology News:Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy 2Cheap, simple, noninvasive blood test may replace invasive diagnostic techniques in early pregnancy 3Irish hares fall foul of modern farming trap 2Going out on a (redwood tree) limb 2Going out on a (redwood tree) limb 3
(Date:6/2/2015)... , June 02, 2015 Research and ... "Molecular Diagnostics - Global Market Size, Strategy and ... offering. "Molecular Diagnostics - Global Market Size, ... that analysts and planners can use. Hundreds of pages ... United States Medicare Fee Payment Schedules to help understand ...
(Date:6/2/2015)... PAULO , June 2, 2015   Hospira, ... in biosimilars, today announced that its partner, Celltrion – a ... – the National Health Surveillance Agency in ... biosimilar monoclonal antibody approved for use in ... Hospira. Hospira also markets and sells biosimilar infliximab in ...
(Date:6/2/2015)... LOUIS , June 2, 2015   ... Life Science and Technology company, announced today it ... Science to launch genetically engineered human neural ... advance the research of neurological diseases. These new ... provide unique and versatile tools for the study ...
(Date:6/2/2015)... Junction, AZ (PRWEB) June 02, 2015 ... light microscope technology, Yancy Corporation is enabling ... any desired material and biological sample, displaying the full ... electron bonds between atoms. , Jeff Porter, Co-Founder of ... physics are just that – rare. They come once ...
Breaking Biology Technology:Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 2Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 3ANVISA Approves First Infliximab Biosimilar in Brazil 2ANVISA Approves First Infliximab Biosimilar in Brazil 3ANVISA Approves First Infliximab Biosimilar in Brazil 4ANVISA Approves First Infliximab Biosimilar in Brazil 5Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2
... age-old fascination with machines mimicking humans has frequently ... mainly because authors and directors could only wildly ... been built yet. According to bionic limb experts ... the distinction between science fiction and reality is ...
... one of the best possible technologies for providing ... to power our civilization. However, for this dream to ... inexpensive elements using low-cost, less energy-intensive processing chemistry, and ... electricity. A team of researchers with the U.S. Department ...
... SynCardia Systems, Inc. ( www.syncardia.com ), manufacturer of the SynCardia ... company pages on Facebook , Twitter and ... about the world,s only FDA, Health Canada and CE (Europe) ... implants of the Total Artificial Heart, accounting for more than ...
Cached Biology Technology:Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 2Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 3Mind-Controlled Bionic Limbs Holding Promise, and the Demand is Growing say IEEE Experts 4Down to the wire 2Down to the wire 3Down to the wire 4SynCardia Goes Social on Facebook, Twitter and LinkedIn 2SynCardia Goes Social on Facebook, Twitter and LinkedIn 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 4
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... This system uses the Adept CE 4100 ... Ultra-Fast Scanning UV/Visible detector for added flexibility and ... a trustworthy alternative to a photodiode array detection ... one detector is required for method development and ...
... number is a new product number, ... number. If showing no availability yet, ... number (E6152) or contact customer service ... diam. 11.25 6.40 in. ...
... Analysis of large numbers of samples may be ... requires minimum operator attention. System control and ... interface CE 4900. The elegant, powerful and ... XP and Windows 98 and 2000., The supplied ...
Biology Products: