Navigation Links
DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
Date:7/14/2013

A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found.

People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukaemia. The new study, led by scientists at Imperial College London and CNRS in France, suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is.

CMEs are defects that result in some cells having extra copies or missing copies of large chunks of DNA. They are very rare in young people but more common as we get older. Among those aged over 70, around one in 50 people have some of these mutations. Research published last year found that people with CMEs have a 10-fold higher risk of blood cancers.

In the new study, published in Nature Genetics, researchers looked for CMEs in blood samples from 7,437 participants in genetic studies in Europe, including 2,208 people with type 2 diabetes. They found that CMEs were four times more common in people with type 2 diabetes.

"Type 2 diabetes is a disease that accelerates ageing, so we wondered if it would make people more likely to have these genetic defects that are associated with ageing," said Professor Philippe Froguel, from the School of Public Health at Imperial College London, who led the study.

"This finding may partly explain why people with type 2 diabetes are more likely to get blood cancers. It could have profound clinical implications. It may be useful for doctors to test for CMEs in patients with type 2 diabetes to identify those who have the highest risk of cancers. These patients would be followed up closely to watch for early signs of leukaemia and could start having mild chemotherapy."

They also found that diabetes patients with CMEs had a much higher rate of complications such as kidney failure, eye disease or heart disease.


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Page: 1

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Study identifies protein that contributes to cognitive decline in Alzheimers
3. OGIs investment in cytognomix contributes to the Shannon Human Splicing Pipelines success
4. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
5. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
6. Texas A&M research contributes to improved ultrasound imaging
7. Scientists identify genetic mechanism that contributed to Irish Famine
8. In beef production, cow-calf phase contributes most greenhouse gases
9. Japanese research organizations contribute to Human Brain Project
10. Study reveals that animals contribute to seagrass dispersal
11. Could poor sleep contribute to symptoms of schizophrenia?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... Station, TX (PRWEB) , ... ... ... Services, LLC (IPS), a leading global provider of engineering, architecture, project controls, ... provider of prefabricated cleanrooms, today announced the unveiling of the iCON™ brand ...
(Date:9/20/2017)... ... September 20, 2017 , ... Foresight Institute, ... and other transformative technologies, announced the winners for the 2017 Foresight Institute Feynman ... Theory in nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... ... Philadelphia’s largest group of funded early-stage tech companies. “Grit” author Angela Duckworth and ... Also joining the ic@3401 community is Cooley, an international law firm with decades ...
(Date:9/19/2017)... ValGenesis Inc., the global leader in Enterprise ... the strategic partnership with VTI Life Sciences (VTI). This ... using the latest technology available in the ValGenesis VLMS ... efficient and cost-effective validation services using ValGenesis VLMS. VTI ... VLMS system. The ...
Breaking Biology Technology: