Navigation Links
DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
Date:7/14/2013

A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found.

People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukaemia. The new study, led by scientists at Imperial College London and CNRS in France, suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is.

CMEs are defects that result in some cells having extra copies or missing copies of large chunks of DNA. They are very rare in young people but more common as we get older. Among those aged over 70, around one in 50 people have some of these mutations. Research published last year found that people with CMEs have a 10-fold higher risk of blood cancers.

In the new study, published in Nature Genetics, researchers looked for CMEs in blood samples from 7,437 participants in genetic studies in Europe, including 2,208 people with type 2 diabetes. They found that CMEs were four times more common in people with type 2 diabetes.

"Type 2 diabetes is a disease that accelerates ageing, so we wondered if it would make people more likely to have these genetic defects that are associated with ageing," said Professor Philippe Froguel, from the School of Public Health at Imperial College London, who led the study.

"This finding may partly explain why people with type 2 diabetes are more likely to get blood cancers. It could have profound clinical implications. It may be useful for doctors to test for CMEs in patients with type 2 diabetes to identify those who have the highest risk of cancers. These patients would be followed up closely to watch for early signs of leukaemia and could start having mild chemotherapy."

They also found that diabetes patients with CMEs had a much higher rate of complications such as kidney failure, eye disease or heart disease.


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Page: 1

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Study identifies protein that contributes to cognitive decline in Alzheimers
3. OGIs investment in cytognomix contributes to the Shannon Human Splicing Pipelines success
4. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
5. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
6. Texas A&M research contributes to improved ultrasound imaging
7. Scientists identify genetic mechanism that contributed to Irish Famine
8. In beef production, cow-calf phase contributes most greenhouse gases
9. Japanese research organizations contribute to Human Brain Project
10. Study reveals that animals contribute to seagrass dispersal
11. Could poor sleep contribute to symptoms of schizophrenia?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... a global clinical research organization (CRO), announces the launch of Shadow, ... 2017. Shadow is designed to assist medical writers and biometrics teams ... European Medicines Agency (EMA) in meeting the requirements for de-identifying clinical ... ... Tom ...
(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... CALIF. (PRWEB) , ... October 10, 2017 , ... San ... part of its corporate rebranding initiative announced today. The bold new look is ... reach, as the company moves into a significant growth period. , It will also ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
Breaking Biology Technology: