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DNA Sequencing: Emerging Technologies and Applications
Date:5/30/2012

NEW YORK, May 30, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

DNA Sequencing: Emerging Technologies and Applications

http://www.reportlinker.com/p0254559/DNA-Sequencing-Emerging-Technologies-and-Applications.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics

INTRODUCTION

STUDY OBJECTIVES

BCC's goal in conducting this study is to provide an overview of the current and future characteristics of the global market for industrial enzymes. The key objective is to present a comprehensive analysis of the current market and its future direction in the enzymes market as an important tool for increasing the efficiency and specificity of the products in which the enzymes are used.

This report is an update to the previous report on industrial enzymes and explores the present and future strategies within the industrial enzymes market, which includes the detergent, technical, food and beverages, and animal feed sectors. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The comparisons, usage, and the advantages and disadvantages of types of enzymes are also portrayed in this report.

A detailed analysis of the enzymes industry structure has been conducted. Revenues are broken down by region. Sales figures are estimated for the five-year period from 2011 through 2016.

Applications for industrial enzymes are also discussed separately in the report, with emphasis of the use in technical enzymes and the food and beverages enzymes. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

With an increase in the use of enzymes, enzyme usage is completely justifiable because they are natural and biodegradable. By using biodegradable enzymes as substitutes in the place of chemical-based products, the manufacturing process is being redeveloped into a more environmentally friendly process, with less corrosive conditions. Enzyme compatibility with the environment in addition to their ability to increase process efficiency and provide product specificity has enhanced the enzymes market globally.

R&D spending, along with increasing competition, patent expiries and new technologies, are directing this in a new direction. The industry took a leap in 2010 with new advancements and the need for cost reductions. This study looks at almost all the systems affected by various factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each type/ technology in light of new technologies, growing competition and changing customer needs.

INTENDED AUDIENCE

This study contributes to the areas of market growth in food and beverages, animal feed, detergents, leather, and other technical enzyme manufacturers and users. Chemical, biochemical and biotechnical companies and industries, and research institutes will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the industrial enzymes, bio-technical, chemical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.

METHODOLOGY

BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with various chemical, biotechnical, food and beverages, and technical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of enzymes in the chemical, biotechnology, food and beverages, leather, and detergent industries. Data were gathered from various industry sources. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has over 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

TABLE OF CONTENTS

CHAPTER ONE: INTRODUCTION 1

STUDY GOALS AND OBJECTIVES 1

REASONS FOR DOING THE STUDY 1

INTENDED AUDIENCE 2

SCOPE AND FORMAT 3

METHODOLOGY 3

INFORMATION SOURCES 4

RELATED BCC REPORTS 4

ANALYST CREDENTIALS 4

BCC ON-LINE SERVICES 4

DISCLAIMER 5

CHAPTER TWO: EXECUTIVE SUMMARY 6

SUMMARY TABLE GLOBAL VALUE OF SEQUENCING PRODUCTS

AND SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 6

SUMMARY FIGURE GLOBAL VALUE OF SEQUENCING PRODUCTS

AND SERVICES BY TYPE, 2010-2016 ($ MILLIONS) 7

EXECUTIVE SUMMARY (CONTINUED) 8

CHAPTER THREE: OVERVIEW 9

INTRODUCTION 9

TABLE 1 SCOPE OF THIS REPORT 9

SEQUENCING INDUSTRY MARKET 10

TABLE 2 GLOBAL VALUE OF THE SEQUENCING MARKET BY

PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 10

SEQUENCING INDUSTRY GROWTH DRIVING FORCES 11

TABLE 3 KEY GROWTH DRIVING FORCES IN THE DNA

SEQUENCING MARKET 11

SEQUENCING PRODUCTS 12

SEQUENCING INSTRUMENTS AND CONSUMABLES 12

SAMPLE PREPARATION REAGENTS AND KITS 13

BIOINFORMATICS 13

SEQUENCING SERVICES 13

SEQUENCING PRODUCT LIFE CYCLE STATUS 14

TABLE 4 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 14

SEQUENCING INDUSTRY 15

TABLE 5 SEQUENCING INSTRUMENT COMPETITORS BY

TECHNOLOGY 15

TABLE 5 (CONTINUED) 16

CHAPTER FOUR: DNA SEQUENCING TECHNOLOGY 17

INTRODUCTION 17

FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA 17

GENOMIC VARIATION 18

TABLE 6 TYPES OF HUMAN GENOME VARIATIONS 18

FIGURE 2 DNA, MRNA, AND GENETIC VARIATION 19

DNA SEQUENCING ANALYSIS 20

TABLE 7 DNA SEQUENCING METHODS 21

HISTORY OF DNA SEQUENCING 21

TABLE 8 DNA SEQUENCING HISTORICAL TIMELINE 21

TABLE 8 (CONTINUED) 22

HISTORY OF DNA SEQUENCING (CONTINUED) 23

HISTORY OF DNA SEQUENCING (CONTINUED) 24

HISTORY OF DNA SEQUENCING (CONTINUED) 25

HISTORY OF DNA SEQUENCING (CONTINUED) 26

FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED

PER DOLLAR 27

FIGURE 4 SEQUENCING INSTRUMENT THROUGHPUT TREND,

BASE PAIRS PER DAY 28

FIGURE 5 HUMAN GENOME SEQUENCING COST TREND 29

FIGURE 6 $1,000 GENOME PRODUCT SPACE 30

DNA SEQUENCING WORKFLOW 31

TABLE 9 DNA SEQUENCING WORKFLOW 31

TARGETING TECHNOLOGIES 32

TABLE 10 CHEMICAL TARGETING TECHNOLOGIES 33

DNA SEQUENCING TECHNOLOGIES 34

TABLE 11 DNA SEQUENCING TECHNOLOGIES 34

NEXT-GENERATION SEQUENCING TECHNOLOGIES 35

TABLE 12 NEXT-GENERATION SEQUENCING TECHNOLOGIES 35

Reversible Termination (Illumina Genome Analyzer and

HiSeq) 35

Pyrosequencing (Roche-454) 36

Sequencing by Ligation (Life Technologies) 37

EMERGING SEQUENCING TECHNOLOGIES 37

TABLE 13 EMERGING SEQUENCING TECHNOLOGIES 38

BENCHTOP SEQUENCERS 39

TABLE 14 BENCHTOP SEQUENCING TECHNOLOGIES 39

SEQUENCING INSTRUMENT PERFORMANCE METRICS 40

TABLE 15 SEQUENCING PLATFORM THROUGHPUT

PERFORMANCE 40

TABLE 16 SEQUENCING PLATFORM ACCURACY PERFORMANCE 41

TABLE 17 SEQUENCING INSTRUMENT COST 42

SEQUENCING INSTRUMENT SUMMARY 42

TABLE 18 SEQUENCING INSTRUMENT SUMMARY 43

BIOINFORMATICS TECHNOLOGIES 44

TABLE 19 NGS SEQUENCING BIOINFORMATICS WORKFLOW 44

Base Calling 45

Mapping to a Reference Sequence 46

TABLE 20 SEQUENCE ANNOTATION TYPES 47

Variant Analysis 47

SEQUENCING PRODUCT LIFE CYCLE 48

TABLE 21 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 49

SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE 49

FIGURE 7 GLOBAL CUMULATIVE INSTALLED BASE OF DNA

SEQUENCERS, THROUGH JANUARY 2012 50

CHAPTER FIVE: DNA SEQUENCING APPLICATIONS 51

INTRODUCTION 51

FIGURE 8 WHOLE-GENOME SEQUENCING PROJECTS FOR

PROKARYOTES AND EUKARYOTES, APRIL 2010 AND DECEMBER

2011 51

FIGURE 8 (CONTINUED) 52

GENETIC ANALYSIS 53

TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON 54

TABLE 23 SEQUENCING ANALYSIS APPLICATIONS 55

TABLE 23 (CONTINUED) 56

TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS 56

DE NOVO WHOLE GENOME SEQUENCING 57

TABLE 25 ESTIMATED NUMBER OF SPECIES ON EARTH AND

PERCENTAGE SEQUENCED, DECEMBER 2011 58

RESEQUENCING 59

Whole-Genome Resequencing 59

FIGURE 9 DISEASE-CAUSING ALLELES AT MAF5 AND MAF1 60

TABLE 26 SINGLE SEQUENCER: WHOLE-GENOME THROUGHPUT

TRENDS, 1975–2011 61

Targeted Resequencing 62

SEQ-BASED METHODS 63

TABLE 27 GENETIC ANALYSIS APPLICATIONS IN WHICH

SEQUENCING COMPETES WITH MICROARRAYS 63

ChIPSeq 64

TABLE 28 COMPARISON OF SEQUENCING WITH MICROARRAYS

FOR CHIP APPLICATIONS 64

DNase-Seq 65

Gene Expression Analysis 65

TABLE 29 COMPARISON OF SEQUENCING AND MICROARRAYS

FOR GENE EXPRESSION ANALYSIS 65

Gene Expression … (Continued) 66

MethylSeq 67

STRUCTURAL VARIATION STUDIES 67

COMPLEMENTARY SEQUENCING AND MICROARRAY

PLATFORMS 68

SEQUENCING END-USE APPLICATIONS 69

RESEARCH, DRUG DISCOVERY AND DEVELOPMENT 69

Research, Drug Discovery … (Continued) 70

TABLE 30 PHARMACEUTICAL/DIAGNOSTICS SEQUENCING

PARTNERS 71

Research, Drug Discovery … (Continued) 72

CLINICAL SEQUENCING 73

TABLE 31 SEQUENCING APPLICATIONS IN CLINICAL

DIAGNOSTICS 73

Clinical Sequencing (Continued) 74

Clinical Sequencing (Continued) 75

TABLE 32 HPV DIAGNOSTICS COMPETITORS 76

CONSUMER SEQUENCING 77

FIGURE 10 GENETIC ANALYSIS COST AND INFORMATION

CONTENT TRENDS (BP/$) 78

Consumer Sequencing (Continued) 79

AGRICULTURAL SEQUENCING 80

TABLE 33 SEQUENCING IMPACT ON AGRICULTURAL PRODUCT

CLASSES 80

MICROBIAL SEQUENCING 81

TABLE 34 KEY APPLICATIONS IN MICROBIAL SEQUENCING 82

FORENSICS SEQUENCING 83

TABLE 35 KEY APPLICATIONS IN FORENSICS AND HUMAN

IDENTITY SEQUENCING 83

CHAPTER SIX: DNA SEQUENCING INITIATIVES 84

FIGURE 11 NIH FUNDING AWARDS FOR DNA SEQUENCINGRELATED

BY INSTITUTE, 2010–2011 85

FIGURE 11 (CONTINUED) 86

FIGURE 12 NIH FUNDING FOR DNA SEQUENCING-RELATED

PROJECTS, 2000–2001 AND 2010–2011 87

NHGRI $1,000 GENOME PROJECT FUNDING 87

TABLE 36 NHGRI GRANTS UNDER THE $1,000 GENOME PROGRAM,

FISCAL YEAR 2009–2011 ($ MILLIONS) 88

SEQUENCING-RELATED GENOMICS PROJECTS 89

TABLE 37 IMPORTANT SEQUENCING RESEARCH INITIATIVES 89

TABLE 37 (CONTINUED) 90

TABLE 37 (CONTINUED) 91

GENOME SEQUENCING PROJECTS 92

Personal Genome Project 92

Archon X Prize in Genomics 92

Genomes 10K Project 93

1,000 Plant and Animal Reference Project 93

MEDICAL SEQUENCING PROJECTS 94

Exome Sequencing of Mendelian Disorders 94

Allelic Spectrum in Common Disease Program 95

Clinseq Project 95

CANCER SEQUENCING PROJECTS 95

International Cancer Genome Consortium 96

Cancer Genome Atlas 96

Tumor Sequencing Project 97

Cancer Genome Project 97

Genomics of Drug Sensitivity in Cancer 98

Catalogue of Somatic Mutations in Cancer 98

Genomics Initiative 99

MICROBIAL SEQUENCING PROJECTS 99

Human Microbiome Project 99

Microbial Genome Sequencing Project 100

Marine Microbial Genome Sequencing Project 100

Fungal Genome Initiative 101

Pathogen Sequencing Program 101

Genomic Encyclopedia of Bacteria and Archaea 101

Metagenomics of the Human Intestinal Tract 102

10,000 Microbial Genomes Project 103

Earth Microbiome Project 103

GENOME VARIATION PROJECTS 103

Encyclopedia of DNA Elements 103

Genomics of Gene Regulation Project 104

1,000 Genomes Project 104

1,000 Plant and Animal Genomes Project 105

Yanhuang Project 105

AGRICULTURAL GENOMICS PROJECTS 106

National Plant Genome Initiative 106

Africa Orphan Crops Consortium 106

IMPACT OF SEQUENCING PROJECTS 106

FIGURE 13 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK,

1988–2011 (BILLIONS) 107

CHAPTER SEVEN: DNA SEQUENCING INDUSTRY STRUCTURE 108

OVERVIEW 108

TABLE 38 DNA SEQUENCING INDUSTRY TRANSITION 108

TABLE 39 DNA SEQUENCING INDUSTRY TRANSITION 109

INDUSTRY STRUCTURE ANALYSIS 109

FIGURE 14 DNA SEQUENCING INDUSTRY STRUCTURE, 1995–2005 110

INDUSTRY STRUCTURE ANALYSIS (CONTINUED) 111

FIGURE 15 DNA SEQUENCING INDUSTRY STRUCTURE, POST-2005 112

SEQUENCING INSTRUMENT AND CONSUMABLES INDUSTRY 113

SEQUENCING INSTRUMENT INDUSTRY 113

TABLE 40 SEQUENCING INSTRUMENT COMPETITORS BY

TECHNOLOGY 114

Sequencing Instrument … (Continued) 115

NGS INSTRUMENT COMPETITOR MARKET SHARES 116

FIGURE 16 NGS INSTRUMENT COMPETITOR MARKET SHARE, 2011

(%) 116

FIGURE 16 (CONTINUED) 117

FIGURE 17 NGS HIGH-THROUGHPUT INSTRUMENT COMPETITOR

MARKET SHARE, 2011 (%) 118

FIGURE 18 NGS BENCHTOP INSTRUMENT COMPETITOR MARKET

SHARE, 2011 (%) 119

EMERGING SEQUENCING INDUSTRY 120

TABLE 41 EMERGING SEQUENCING INDUSTRY 120

TABLE 42 NANOPORE SEQUENCING INDUSTRY 121

TABLE 43 POTENTIAL BENEFITS OF NANOPORE SEQUENCING 122

DNA SEQUENCING END USERS 122

TABLE 44 DNA SEQUENCING END-USER MARKET SEGMENTS 123

Major Sequencing Centers 123

TABLE 45 TOP 10 NGS INSTRUMENT INSTALLATIONS BY MAJOR

SEQUENCING CENTER, DECEMBER 2011 124

FIGURE 19 MAJOR SEQUENCING CENTER'S SHARE OF THE

GENOME SEQUENCING PROJECTS MARKET BY NUMBER OF

SEQUENCING PROJECTS, DECEMBER 2011 (%) 125

FIGURE 20 BGI ADOPTION OF NEXT-GENERATION SEQUENCERS,

2008 AND 2011 126

FIGURE 20 (CONTINUED) 127

Large-Core Sequencing Centers 127

TABLE 46 LARGE-CORE SEQUENCING CENTERS 128

Small to Mid-Size Laboratories 129

Sequencing Service Laboratories 129

EARLY ADAPTORS 130

SEQUENCING SAMPLE PREPARATION INDUSTRY 130

SEQUENCE CAPTURE INDUSTRY 131

TABLE 47 POSITIONING OF SEQUENCE CAPTURE FORMATS 131

SAMPLE PREP COMPETITORS 132

TABLE 48 SEQUENCING SAMPLE PREPARATION COMPANY

POSITIONING 133

Sample Prep Competitors (Continued) 134

Sample Prep Competitors (Continued) 135

TABLE 49 PREPARATION FORMATS 136

DIGITAL PCR INDUSTRY 136

TABLE 50 DIGITAL PCR INDUSTRY 137

Digital PCR Industry (Continued) 138

BIOINFORMATICS INDUSTRY 139

TABLE 51 DNA SEQUENCING BIOINFORMATICS COMPANY

POSITIONING 140

PHYSICAL MAPPING 141

TABLE 52 PHYSICAL MAPPING INDUSTRY 142

SEQUENCING SERVICES INDUSTRY 142

TABLE 53 DNA SEQUENCING SERVICES COMPANIES AND

INSTITUTIONS POSITIONING BY MARKET FOCUS 143

CLINICAL SEQUENCING INDUSTRY 144

TABLE 54 LABORATORIES OFFERING NGS CLINICAL

SEQUENCING SERVICES 145

Clinical Sequencing Industry (Continued) 146

Clinical Sequencing Industry (Continued) 147

CONSUMER SEQUENCING INDUSTRY 148

TABLE 55 MEDIUM- TO HIGH-CONTENT CONSUMER GENOMICS

COMPANIES 148

TABLE 55 (CONTINUED) 149

FIGURE 21 PERSONAL GENOMICS COMPETITIVE SPACE BY TEST

COST AND SCOPE 150

TABLE 56 CONSUMER GENOMICS COMPETITOR STRATEGIES ($) 151

AGRICULTURAL GENOMICS INDUSTRY 152

TABLE 57 KEY COMPETITORS IN THE AGRICULTURAL SEED

MARKET 152

AGRICULTURAL GENOMICS INDUSTRY (CONTINUED) 153

SEQUENCING INDUSTRY ACQUISITIONS AND STRATEGIC

ALLIANCES 154

ACQUISITIONS 154

TABLE 58 SEQUENCING INDUSTRY ACQUISITIONS, 2009–2011 154

TABLE 58 (CONTINUED) 155

STRATEGIC ALLIANCES 156

TABLE 59 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2009–

2011 157

TABLE 59 (CONTINUED) 158

TABLE 59 (CONTINUED) 159

TABLE 59 (CONTINUED) 160

CLINICAL SEQUENCING ALLIANCES 161

Sequencing Workflow Alliances 162

Sequencing … (Continued) 163

Sequencing … (Continued) 164

Emerging Sequencing Technology Alliances 165

Sequencing Market Expansion Alliances 166

Sequencing Market … (Continued) 167

Sequencing Market … (Continued) 168

CHAPTER EIGHT: DNA SEQUENCING MARKETS 169

GROWTH DRIVING FORCES 169

TABLE 60 DNA SEQUENCING KEY GROWTH DRIVING FORCES 169

GROWTH DRIVING FORCES (CONTINUED) 170

GROWTH DRIVING FORCES (CONTINUED) 171

SEQUENCING MARKET SUMMARY 172

TABLE 61 GLOBAL VALUE OF THE SEQUENCING MARKET BY

PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 172

SEQUENCING MARKET SUMMARY (CONTINUED) 173

SEQUENCING INSTRUMENTS AND CONSUMABLES MARKETS 174

TABLE 62 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS

AND CONSUMABLES MARKET BY PRODUCT TYPE, THROUGH

2016 ($ MILLIONS) 174

SEQUENCING INSTRUMENTS AND CONSUMABLES BY

PLATFORM 175

TABLE 63 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY

PLATFORM, THROUGH 2016 ($ MILLIONS) 175

Sequencing Instruments …(Continued) 176

TABLE 64 GLOBAL VALUE OF THE SEQUENCING CONSUMABLES

MARKET BY PLATFORM, THROUGH 2016 ($ MILLIONS) 177

NGS INSTRUMENTS AND CONSUMABLES BY PLATFORM 178

TABLE 65 GLOBAL VALUE OF NGS INSTRUMENTS AND

CONSUMABLES BY PLATFORM, THROUGH 2016 ($ MILLIONS) 178

SEQUENCING INSTRUMENTS AND CONSUMABLES BY

END USER 179

TABLE 66 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND

CONSUMABLES BY CUSTOMER TYPE, THROUGH 2016 ($

MILLIONS) 179

Sequencing Instruments … (Continued) 180

TABLE 67 GLOBAL VALUE OF SANGER SEQUENCING

INSTRUMENTS AND CONSUMABLES BY CUSTOMER TYPE,

THROUGH 2016 ($ MILLIONS) 181

TABLE 68 GLOBAL VALUE OF NGS SEQUENCING INSTRUMENTS

AND CONSUMABLES BY CUSTOMER TYPE, THROUGH 2016 ($

MILLIONS) 182

TABLE 69 GLOBAL VALUE OF EMERGING SEQUENCING

INSTRUMENTS AND CONSUMABLES BY CUSTOMER TYPE,

THROUGH 2016 ($ MILLIONS) 183

SEQUENCING SAMPLE PREP MARKETS 183

TABLE 70 GLOBAL VALUE OF THE SEQUENCING SAMPLE PREP

MARKET BY APPLICATION, THROUGH 2016 ($ MILLIONS) 184

SEQUENCING BIOINFORMATICS MARKET 185

TABLE 71 GLOBAL VALUE OF THE SEQUENCING

BIOINFORMATICS MARKET BY SOFTWARE FUNCTION,

THROUGH 2016 ($ MILLIONS) 185

SEQUENCING SERVICES MARKETS 186

SEQUENCING SERVICES BY END-USER MARKET 186

TABLE 72 GLOBAL VALUE OF SEQUENCING SERVICES BY ENDUSER

MARKET, THROUGH 2016 ($ MILLIONS) 186

R&D, Pharma and Biotech 187

Consumer Sequencing 188

SEQUENCING SERVICES MARKETS BY TYPE OF

ANALYSIS 189

TABLE 73 GLOBAL VALUE OF SEQUENCING SERVICES BY

ANALYSIS TYPE, THROUGH 2016 ($ MILLIONS) 189

SEQUENCING SERVICES MARKET BY SPECIES 190

TABLE 74 GLOBAL VALUE OF SEQUENCING SERVICES BY

GENOME TYP THROUGH 2016 ($ MILLIONS) 191

APPLIED SEQUENCING SERVICES MARKET 191

TABLE 75 GLOBAL VALUE OF THE APPLIED SEQUENCING

SERVICES MARKET BY APPLICATION, THROUGH 2016 ($

MILLIONS) 191

Applied Sequencing … (Continued) 192

CLINICAL SEQUENCING SERVICES MARKET 193

Summary 193

TABLE 76 GLOBAL VALUE OF CLINICAL SEQUENCING SERVICES

BY INDICATION, THROUGH 2016 ($ MILLIONS) 194

TABLE 77 GLOBAL VALUE OF CLINICAL SEQUENCING TESTS BY

TECHNOLOGY, THROUGH 2016 ($ MILLIONS) 195

TABLE 78 CLINICAL DIAGNOSTICS PLATFORM COMPARISON 196

Summary (Continued) 197

TABLE 79 STABILIZING MARKET FACTORS FOR SANGER

CLINICAL SEQUENCING 198

Cancer 198

TABLE 80 GLOBAL VALUE OF CLINICAL CANCER SEQUENCING

SERVICES BY INDICATION, THROUGH 2016 ($ MILLIONS) 199

Infectious Diseases 199

TABLE 81 GLOBAL VALUE OF CLINICAL INFECTIOUS DISEASE

SEQUENCING SERVICES BY INDICATION, THROUGH 2016 ($

MILLIONS) 200

Genetic Diseases 201

TABLE 82 GLOBAL VALUE OF CLINICAL GENETIC DISEASE

SEQUENCING SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 201

TABLE 83 PRENATAL DIAGNOSTICS TESTS 202

Genetic Diseases (Continued) 203

Immunology 204

TABLE 84 GLOBAL VALUE OF IMMUNOLOGY CLINICAL

SEQUENCING SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 205

TABLE 85 HLA TESTING MARKET 206

SEQUENCING MARKETS BY REGION 207

SUMMARY 207

TABLE 86 GLOBAL VALUE OF THE DNA SEQUENCING MARKET BY

REGION, THROUGH 2016 ($ MILLIONS) 208

SEQUENCING INSTRUMENTS AND CONSUMABLES BY

REGION 209

TABLE 87 GLOBAL VALUE OF THE SEQUENCING INSTRUMENT

AND CONSUMABLES MARKET BY REGION, THROUGH 2016 ($

MILLIONS) 209

Sequencing Instruments …(Continued) 210

TABLE 88 GLOBAL VALUE OF THE SEQUENCING SAMPLE PREP

MARKET BY REGION, THROUGH 2016 ($ MILLIONS) 211

SEQUENCING BIOINFORMATICS MARKET BY REGION 211

TABLE 89 GLOBAL VALUE OF THE SEQUENCING

BIOINFORMATICS MARKET BY REGION, THROUGH 2016 ($

MILLIONS) 212

SEQUENCING SERVICES MARKET BY REGION 212

TABLE 90 GLOBAL VALUE OF THE SEQUENCING SERVICES

MARKET BY REGION, THROUGH 2016 ($ MILLIONS) 212

U S SEQUENCING MARKET 213

TABLE 91 GLOBAL VALUE OF THE U S SEQUENCING MARKET BY

PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 213

GERMANY SEQUENCING MARKET 214

TABLE 92 GLOBAL VALUE OF THE GERMANY SEQUENCING

MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 214

U K SEQUENCING MARKET 215

TABLE 93 GLOBAL VALUE OF THE U K SEQUENCING MARKET BY

PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 215

CHINA SEQUENCING MARKET 216

TABLE 94 GLOBAL VALUE OF THE CHINA SEQUENCING MARKET

BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 216

JAPAN SEQUENCING MARKET 216

TABLE 95 GLOBAL VALUE OF THE JAPAN SEQUENCING MARKET

BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 217

CHAPTER NINE: SEQUENCING PATENTS 218

FIGURE 22 SEQUENCING PATENTS, 2001–2011 218

FIGURE 22 (CONTINUED) 219

FIGURE 23 SEQUENCING PATENTS BY REGION, 2001–2011 219

FIGURE 24 EMERGING SEQUENCING COMPANY PATENTS BY

REGION 220

FIGURE 24 (CONTINUED) 221

CHAPTER TEN: COMPANY PROFILES 222

23ANDME INC 222

ACCELRYS INC 223

ADAPTIVE TCR TECHNOLOGIES 223

AGILENT TECHNOLOGIES INC 224

ALTHEADX 225

AMBRY GENETICS 226

ASTRID BIOSCIENCE GMBH 226

ASURAGEN INC 227

AXEQ TECHNOLOGIES 228

BASE4INNOVATION LTD 228

BECKMAN COULTER 229

BGI 230

BGI (CONTINUED) 231

BIO LOGIS GMBH 232

BIOMATTERS LTD 232

BIONANO GENOMICS INC 233

BIOTIQUE SYSTEMS INC 233

BLUESEQ 234

TABLE 96 SEQUENCING MATCHING SERVICE PROVIDERS 235

CAERUS MOLECULAR DIAGNOSTICS 235

CARTAGENIA N V 235

COFACTOR GENOMICS 236

COMPLETE GENOMICS INC 236

CONEXIO GENOMICS 237

CORRELAGEN DIAGNOSTICS INC 238

CUSTOMARRAY INC 238

DANAHER 239

DECODEME 240

DNA ELECTRONICS LTD 241

DNANEXUS INC 241

DNASTAR INC 242

DNA VISION 243

ELECTRONIC BIOSCIENCES 243

ELECTRON OPTICA 244

EUROFINS MEDIGENOMIX GMBH 244

EUROFINS MWG OPERON 245

EXISTENCE GENETICS 246

EXPRESSION ANALYSIS INC 246

FASTERIS SA 247

FIREBIRD BIOMOLECULAR SCIENCES LLC 247

FLUIDIGM CORPORATION 248

FOUNDATION FOR APPLIED MOLECULAR EVOLUTION 249

FOUNDATION MEDICINE 249

GATC BIOTECH AG 250

GE HEALTHCARE 251

GENAPSYS 252

GENDX BV 252

GENEDATA AG 253

GENEDX INC 253

GENIA 254

TABLE 97 COMMERCIAL SEQUENCER COMPETITIVE

POSITIONING 255

GENOMATIX SOFTWARE GMBH 255

GENOMEQUEST INC 256

GENOMIC HEALTH INC 257

GENOVOXX GMBH 258

GEN-PROBE INC 259

GNUBIO INC 259

GOOD START GENETICS INC 260

HALCYON MOLECULAR 261

HALO GENOMICS AB 261

HELICOS BIOSCIENCES CORPORATION 262

INTERNATIONAL BUSINESS MACHINES CORP 263

ILLUMINA INC 264

TABLE 98 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT

($ PER YEAR) 264

INGENUITY SYSTEMS INC 265

INTEGENX 266

INTELLIGENT BIO-SYSTEMS INC 267

INTELLIGENT BIO-SYSTEMS INC (CONTINUED) 268

INTERNA GENOMICS BV 269

IP GENESIS INC 269

IREPERTOIRE 270

ISENTIO AS 271

KEYGENE N V 271

KNOME INC 272

LABORATORY FOR MOLECULAR MEDICINE 273

LASERGEN INC 274

LI-COR BIOSCIENCES 274

LIFECODEXX AG 275

LIFE TECHNOLOGIES INC 276

LINGVITAE HOLDING AS 277

LOCUS DEVELOPMENT INC 278

MACROGEN INC 278

MEDOMICS 279

MOOSBAUM GMBH 279

MYCROARRAY COM 280

NABSYS INC 280

NAVIGENICS INC 281

NETWORK BIOSYSTEMS 282

NEWGENE LTD 282

NOBLEGEN BIOSCIENCES 283

NOVOCRAFT TECHNOLOGIES INC 284

NUGEN TECHNOLOGIES INC 284

OMICIA INC 285

OPGEN INC 286

OXFORD GENE TECHNOLOGY 287

OXFORD NANOPORE TECHNOLOGIES 287

OXFORD NANOPORE … (CONTINUED) 288

PACIFIC BIOSCIENCES 289

PATHOGENICA 290

PATHOGENETIX 291

PERKINELMER INC 291

PERKINELMER INC (CONTINUED) 292

PERSONALIS 293

POPULATION GENETICS TECHNOLOGIES LTD 293

POPULATION GENETICS … (CONTINUED) 294

PROGNOSYS BIOSCIENCES INC 295

QIAGEN 296

QUANTALIFE INC 296

QUANTUMDX 297

RAINDANCE TECHNOLOGIES INC 297

TABLE 99 RAINDANCE STRATEGIC ALLIANCES 298

RAINDANCE TECHNOLOGIES INC (CONTINUED) 299

REAL TIME GENOMICS INC 300

ROCHE HOLDING AG 300

ROCHE HOLDING AG (CONTINUED) 301

RUBICON GENOMICS INC 302

SEQUENOM INC 303

SEQUENTA INC 304

SEQWRIGHT 305

SIEMENS AG 305

SLIPCHIP LLC 306

SMARTGENE SERVICES SARL 307

SOURCE BIOSCIENCE PLC 307

SORENSON GENOMICS 308

STRATOS GENOMICS INC 308

SUNDANCE DIAGNOSTICS INC 309

SISTEMAS GENOMICOS 309

THERAGEN ETEX CO LTD 310

TRANSGENOMIC INC 310

TROVAGENE INC 311

VERINATA HEALTH INC 312

WARP DRIVE BIO, LLC 312

X PRIZE FOUNDATION 313

ZS GENETICS 314

ZS GENETICS (CONTINUED) 315

REFERENCES 316

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Genomics Industry: DNA Sequencing: Emerging Technologies and Applications

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