Navigation Links
DBS studies show how brain buys time for tough choices
Date:9/25/2011

PROVIDENCE, R.I. [Brown University] Take your time. Hold your horses. Sleep on it.

When people must decide between arguably equal choices, they need time to deliberate. In the case of people undergoing deep brain stimulation (DBS) for Parkinson's disease, that process sometimes doesn't kick in, leading to impulsive behavior. New research into why that happens has led scientists to a detailed explanation of how the brain devotes time to reflect on tough choices.

Michael Frank, professor of cognitive, linguistic, and psychological sciences at Brown University, studied the impulsive behavior of Parkinson's patients when he was at the University of Arizona several years ago. His goal was to model the brain's decision-making mechanics. He had begun working with Parkinson's patients because DBS, a treatment that suppresses their tremor symptoms, delivers pulses of electrical current to the subthalamic nucleus (STN), a part of the brain that Frank hypothesized had an important role in decisions. Could the STN be what slams the brakes on impulses, giving the medial prefrontal cortex (mPFC) time to think?

"We didn't have any direct evidence of that," said Frank, who is affiliated with the Brown Institute for Brain Science. "To test that theory for how areas of the brain interact to prevent you from making impulsive decisions and how that could be changed by DBS, you have to do experiments where you record brain activity in both parts of the network that we think are involved. Then you also have to manipulate the system to see how the relationship between recorded activity in one area and decision making changes as a function of stimulating the other area."

Frank and his team at Brown and Arizona did exactly that. They describe their findings in a study published online in the journal Nature Neuroscience.

The researchers' measurements from two experiments and analysis with a computer model support the theory that when
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New studies find global warming will have significant economic impacts on Florida coasts
2. NIHs Genes, Environment and Health Initiative adds 6 studies
3. 6 environmental research studies reveal critical health risks from plastic
4. NIAID funds studies of how SARS and bird flu evade antiviral responses
5. Drug-embedded microparticles bolster heart function in animal studies
6. ASU researchers receive NIH awards for studies of malaria and emergent disease
7. Studies of small water fleas help ecologists understand population dynamics
8. MSU researcher studies ties between cholesterol drugs, muscle problems
9. UI researchers help to improve carbon measurements in global climate studies
10. Studies on imaging and tracking transplanted cells
11. To improve forecasting earthquakes, NJIT mathematician studies grains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ...  report to their offering. One ... in technology. With continuous advances in technology, it ... latest standard that meets the needs and expectations ...
(Date:12/10/2014)... -- Valencell, a leader in performance biometric data sensor technology, ... its licensees for highly accurate, clinically validated biometric technology. ... from fitness and health sectors, but first responders/military and ... only as useful as the biometric data it delivers. ... long-term mass consumer adoption of wearable products," said Dr. ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased ... boosted investments in new testing and inspection technologies. ... given rise to a range of innovative test ... requirements of Generation Y, which is generally more ... a result, product development strategies of test equipment ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... of its strategic plan, " Forging the Future A ... Genome Institute (DOE JGI) has positioned itself to provide the ... they can address pressing energy and environmental scientific challenges. ... the launch of the Emerging Technologies Opportunity Program (ETOP) ...
... Once famously described as "orphan diseases, too small to ... Hollywood drama "Lorenzo,s Oil," rare diseases are getting unprecedented ... research efforts and marketing new medicines that promise fuller ... conditions. That,s the finding of a major examination, ...
... own function by "accelerating and braking" is important basic knowledge ... cells are tweaked to produce more bioenergy. In a study ... Uppsala and Ume universities show a model of how cells, ... system similar to what can be found in today,s smartphones. ...
Cached Biology News:The DOE Joint Genome Institute expands capabilities via new partnerships 2The DOE Joint Genome Institute expands capabilities via new partnerships 3Cells must use their brakes moderately for effective speed control 2
(Date:12/22/2014)... 2014  ( www.competitivehealth.com ) — Competitive Health is ... review and advocacy service, has signed an agreement to ... discount health services marketplace. 63% of Americans ... they expected to pay. As part of an ongoing ... Savings is pleased to offer medical bill review and ...
(Date:12/22/2014)... ITRA Global, one of the largest organizations ... estate, has further expanded its global reach with the ... Western Australia, reports Mylinda Vick, CCIM, Chairman of the ... / ACORPP (Australian Corporate Property and Projects) , is ... services to a wide range of clients in the ...
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... past two years have been particularly difficult for telecom and high-technology ... Their own executives did them in, is a shout that I ... long. Now they have to compete, and they are falling on ... , ,But there is also truth to what a telecom President ...
... 11 Sonic Foundry a rich media solutions company, today ... Learning will use its Mediasite Live rich media Web ... presentations, and make them available on-demand via the Web ... ,Held Aug. 13-15 at the Monona Terrace Conference Center ...
... left the ministry years ago, but he hasn't given up ... and speaker on all things Internet spotlights old ways of ... , ,"The first requirement is to be willing to become ... about our culture that prevent us from encouraging, supporting, and ...
Cached Biology Technology:ARE WE THERE YET? 2Distance Education Conference Selects Sonic Foundry to Make Keynotes, Panel Presentations Available On-Demand 2Dream Thieme 2
Donor Goat Serum...
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
... monoclonal [APS 26] to Presenilin 2 ... form of the disease carry mutations in ... amyloid precursor protein (APP). These disease-linked mutations ... form of amyloid-beta (main component of amyloid ...
One-step, microplate or cuvet, colorimetric, linear detection range 0.9 mg/dL to 200 mg/dL. Procedure: 2 min....
Biology Products: