Navigation Links
Cystic fibrosis proteins photographed interacting
Date:12/7/2007

BIRMINGHAM, Ala. New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease.

Researchers at the University of Alabama at Birmingham (UAB) studied a CF-causing protein and another protein called epithelial sodium channel, or ENaC. Both proteins are known to play a role in CF, but exactly what role each plays is unclear.

The new pictures provide physical proof that these two proteins occur close enough to interact with each other, the UAB researchers said. When that interaction fails then a dangerous biochemical imbalance occurs in people diagnosed with CF.

Knowing more about this protein proximity will help scientists better understand the biological underpinnings of CF and may speed the discovery of new drugs to treat or cure the disease. CF affects 70,000 people worldwide, 30,000 in the United States.

The findings are published in the Journal of Biological Chemistry, which included a color photo from the UAB study on its cover.

Our findings suggest a direct interaction between these two proteins and their proximity makes the evidence convincing, said Bakhrom Berdiev, M.D., Ph.D., a UAB assistant professor of cell biology and lead author on the study.

The study was conducted using a laser-scanning microscope that captured images of the two proteins within reach of each other. The absence of this interaction could shape the development of CF, Berdiev said.

Normally, both proteins help make up the lining of the lungs and other membranes, and keep the balance of water and salt at safe levels. In the case of CF, ENaC is allowed to hyper-function in the presence of the CF-causing protein and disturb the balance of water and salt.

When this happens, a sticky mucus usually forms inside the airways which can lead to chronic lung infections, the most dangerous symptom of CF. Other symptoms involve digestive problems.

With the discovery of the CF gene in 1989, many scientists began searching for ways to repair the DNA or repair the faulty protein encoded by the DNA.

The new Journal of Biological Chemistry study shows that future research should look at other molecules not directly linked to CF but are involved in the disease process and its side effects, Berdiev said.

Also, the new pictures add to an ever-changing biophysical map of CF used to design future research.

The new pictures were done through collaboration between UABs departments of Cell Biology, Physiology & Biophysics, High Resolution Imaging Facility and the Gregory Fleming James Cystic Fibrosis Research Center at UAB. Other collaborators are from Ohio State University, the University of Toronto, Ontario, the National Heart Lung and Blood Institute in Bethesda, Maryland and Lambert Instruments in the Netherlands.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham  
Source:Eurekalert

Related biology news :

1. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
2. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
6. Depression, aging, and proteins made by a virus may all play role in heart disease
7. New approach builds better proteins inside a computer
8. Legionnaires bacterial proteins work together to survive
9. Proteins pack tighter in crowded native state
10. MIT IDs proteins key to brain function
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cystic fibrosis proteins photographed interacting
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... 30, 2016 /PRNewswire/ - Portage Biotech Inc. ("Portage" or ... is excited to announce the formation of EyGen, ... preclinical ophthalmology assets through proof of concept. EyGen,s ... by Portage Pharmaceuticals Limited and being developed for ... and anterior segment diseases. This agent has the ...
(Date:11/30/2016)... /PRNewswire/ -  Equicare Health Inc ., the leading supplier ... one of the top 100 companies in the 2016 ... distinguishes the top digital health companies across the globe. ... this year continually upgrading our product with the ongoing ... team," says Len Grenier , CEO of Equicare ...
(Date:11/30/2016)... November 2016   Merck , ein ... Unterzeichnung einer Reihe von Vereinbarungen mit Evotec ... AG Screeningleistungen für Mercks Palette genetischer Reagenzien ... auf diese Bibliotheken in Kombination mit Evotecs ... Weg zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
(Date:11/30/2016)... , ... November 30, 2016 , ... SSCI, the established ... discuss the implications of the latest FDA guidance on pharmaceutical cocrystals as drug ... in Cambridge, MA. , The event follows the successful November 15th event ...
Breaking Biology Technology: