Navigation Links
Cystic fibrosis proteins photographed interacting
Date:12/7/2007

BIRMINGHAM, Ala. New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease.

Researchers at the University of Alabama at Birmingham (UAB) studied a CF-causing protein and another protein called epithelial sodium channel, or ENaC. Both proteins are known to play a role in CF, but exactly what role each plays is unclear.

The new pictures provide physical proof that these two proteins occur close enough to interact with each other, the UAB researchers said. When that interaction fails then a dangerous biochemical imbalance occurs in people diagnosed with CF.

Knowing more about this protein proximity will help scientists better understand the biological underpinnings of CF and may speed the discovery of new drugs to treat or cure the disease. CF affects 70,000 people worldwide, 30,000 in the United States.

The findings are published in the Journal of Biological Chemistry, which included a color photo from the UAB study on its cover.

Our findings suggest a direct interaction between these two proteins and their proximity makes the evidence convincing, said Bakhrom Berdiev, M.D., Ph.D., a UAB assistant professor of cell biology and lead author on the study.

The study was conducted using a laser-scanning microscope that captured images of the two proteins within reach of each other. The absence of this interaction could shape the development of CF, Berdiev said.

Normally, both proteins help make up the lining of the lungs and other membranes, and keep the balance of water and salt at safe levels. In the case of CF, ENaC is allowed to hyper-function in the presence of the CF-causing protein and disturb the balance of water and salt.

When this happens, a sticky mucus usually forms inside the airways which can lead to chronic lung infections, the most dangerous symptom of CF. Other symptoms involve digestive prob
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
2. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
6. Depression, aging, and proteins made by a virus may all play role in heart disease
7. New approach builds better proteins inside a computer
8. Legionnaires bacterial proteins work together to survive
9. Proteins pack tighter in crowded native state
10. MIT IDs proteins key to brain function
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cystic fibrosis proteins photographed interacting
(Date:9/29/2014)... annual Advocacy Awards will ... advancing medical progress to improve the health and ... take place on Wednesday, March 11, 2015, at ... , The 2015 Advocacy Award winners are ABC,s ... founder of the Milken Institute and FasterCures; Dr. ...
(Date:9/29/2014)... beginning of the age of dinosaurs, gigantic reptilesdistant relatives ... and others in water and it was thought they ... University of Tennessee, Knoxville, researcher in the thigh of ... , Stephanie Drumheller, an earth and planetary sciences ... Sterling Nesbitt examined 220-million-year-old bite marks in the thigh ...
(Date:9/29/2014)... Institute (DOE JGI), a DOE Office of Science ... have been selected for the 2015 Community Science ... waters, and from plant root micro-ecosystems, to the ... the CSP 2015 projects portfolio highlights diverse environments ... , "These projects catalyze JGI,s strategic shift in ...
Breaking Biology News(10 mins):Research!America to honor leaders in medical and health research advocacy 2Research!America to honor leaders in medical and health research advocacy 3Research!America to honor leaders in medical and health research advocacy 4Tooth serves as evidence of 220 million-year-old attack 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9
... neighbors, and now researchers reporting in the June 22 issue ... they have a motive. It appears that chimps, and especially ... gain territory. "The take-home is clear and simple," ... each other. They kill their neighbors. Up until now, we ...
... which aims to develop a new, higher-yielding rice plant which could ... by an academic at the University of Sheffield. Currently, more ... a day and nearly one billion live in hunger. Over the ... about 50 per cent and water scarcity will grow. About half ...
... international public-private consortium to build the most detailed map ... of three pilot projects and the deposition of the ... use by the research community. In addition, work has ... database containing information from the genomes of 2,500 people ...
Cached Biology News:Why chimpanzees attack and kill each other 2Rice yields researched to tackle food security issues 2Rice yields researched to tackle food security issues 3Freely available data supporting next generation of human genetic research 2Freely available data supporting next generation of human genetic research 3Freely available data supporting next generation of human genetic research 4Freely available data supporting next generation of human genetic research 5Freely available data supporting next generation of human genetic research 6
(Date:9/29/2014)...  Perrigo Company plc (NYSE: PRGO ... a portfolio of preclinical research assets, which it ... Corporation plc, to drug discovery and development company, ... will receive an upfront payment in addition to ... future sales derived from the portfolio. ...
(Date:9/29/2014)... Westbridge Agricultural Products announced today ... highly effective new tool for organic growers. SUPPRESS™ ... contact herbicide for post-emergent, non-selective weed control for ... The formulation is an emulsifiable concentrate that has ... (OMRI) for use in organic food production. , ...
(Date:9/27/2014)... German . ... precisely surveying the surface topology of samples, but also ... exciting the atoms to fluoresce under irradiation by an ... provides information about the location and type of element, ... lighter elements of the periodic table such as lithium, ...
(Date:9/26/2014)... -- Research and Markets  has announced the addition ... Market Developments, Growth Areas and Opportunities" report to ... global end-user study and market analysis relating to the ... the laboratory. Market findings from this study ... research scientists and clinicians who routinely use nucleic acid ...
Breaking Biology Technology:Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2'Multi-spectra glasses' for scanning electron microscopy 2DNA and RNA Sample Preparation Markets: Market Developments, Growth Areas and Opportunities 2DNA and RNA Sample Preparation Markets: Market Developments, Growth Areas and Opportunities 3
... Educational program offers unique resources to empower transplant patients ... ... Oct. 17 Astellas Pharma US,Inc. (Pink Sheets: ALPMF), a ... Society (ITNS), a leading transplant,professional organization, announced a collaborative partnership ...
... to Dominate the Type 2 Diabetes Market, According to a ... New Report from Decision Resources, ... have released a new report finding that Merck,will obtain blockbuster antidiabetic ... uptake of their DPP-IV inhibitor, Januvia.,Januvia will see rapid uptake as ...
... 24, at 1:30 p.m. EDT, ALAMEDA, Calif., ... a biopharmaceutical company developing innovative therapies,for the treatment ... to discuss third quarter results on Wednesday, October ... Kenneth Chahine, Chief Executive,Officer, and Michael Coffee, Chief ...
Cached Biology Technology:Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 2Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 3Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011 2Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011 3Avigen, Inc. Announces Third Quarter 2007 Earnings Conference Call 2
Anti-Potassium Channel EAG-1 Immunogen: Synthetic peptide from the C-terminus of rat Kv10.1 (Accession Q63472). The immunogen sequence is identical in mouse and 14/16 residues identical in human...
WIF-1 (N-20)...
VEGF Receptor-2, phospho-specific (Tyr996)...
For the differentiation of mouse embryonic stem cells tooligodendrocytes....
Biology Products: