Navigation Links
Cystic fibrosis proteins photographed interacting
Date:12/7/2007

BIRMINGHAM, Ala. New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease.

Researchers at the University of Alabama at Birmingham (UAB) studied a CF-causing protein and another protein called epithelial sodium channel, or ENaC. Both proteins are known to play a role in CF, but exactly what role each plays is unclear.

The new pictures provide physical proof that these two proteins occur close enough to interact with each other, the UAB researchers said. When that interaction fails then a dangerous biochemical imbalance occurs in people diagnosed with CF.

Knowing more about this protein proximity will help scientists better understand the biological underpinnings of CF and may speed the discovery of new drugs to treat or cure the disease. CF affects 70,000 people worldwide, 30,000 in the United States.

The findings are published in the Journal of Biological Chemistry, which included a color photo from the UAB study on its cover.

Our findings suggest a direct interaction between these two proteins and their proximity makes the evidence convincing, said Bakhrom Berdiev, M.D., Ph.D., a UAB assistant professor of cell biology and lead author on the study.

The study was conducted using a laser-scanning microscope that captured images of the two proteins within reach of each other. The absence of this interaction could shape the development of CF, Berdiev said.

Normally, both proteins help make up the lining of the lungs and other membranes, and keep the balance of water and salt at safe levels. In the case of CF, ENaC is allowed to hyper-function in the presence of the CF-causing protein and disturb the balance of water and salt.

When this happens, a sticky mucus usually forms inside the airways which can lead to chronic lung infections, the most dangerous symptom of CF. Other symptoms involve digestive prob
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
2. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
3. CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
6. Depression, aging, and proteins made by a virus may all play role in heart disease
7. New approach builds better proteins inside a computer
8. Legionnaires bacterial proteins work together to survive
9. Proteins pack tighter in crowded native state
10. MIT IDs proteins key to brain function
11. Interacting protein theory awaits test from new neutron analysis tools
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cystic fibrosis proteins photographed interacting
(Date:1/22/2015)... and POINT ROBERTS, Washington , January ... covering leading sectors including technology and tech stocks, releases video ... featuring master pickpocket and security consultant Apollo Robbins . ... and talks about the Wocket™ biometric smart wallet, a product ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced ... - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of AuthenTec ... with the iPhone 5S. It is currently the only ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... Down syndrome (DS) is the most common genetic disorder ... a chromosomal abnormality. It occurs as a result of ... usual two. It causes substantial physical and behavioral abnormalities, ... to severe but which further deteriorates as individuals with ...
... Tropical Research Institute and University of Costa Rica asked ... webs. Repeating old, widely quoted but poorly documented studies ... legs are protected by a covering of branching hairs ... published online in the journal, Naturwissenschaften . , ...
... in size over time, they haven,t necessarily grown in ... according to a recently published study appearing in the ... scientists from the USDA Forest Service and the University ... of wildfires on four national forestsKlamath, Mendocino, Shasta-Trinity and ...
Cached Biology News:Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimer's disease 2Study of wildfire trends in Northwestern California shows no increase in severity over time 2
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. ... marketer of proprietary clinical grade hypothermic storage and ... products for cells and tissues  ("BioLife" or the "Company"), ... of Stockholders on May 4, 2015 (the "Annual Meeting"). ...
(Date:12/24/2014)... 23, 2014 On Friday, December 19, ... Omnibus and Continuing Resolution Appropriations Act of 2015, which ... to receive funding through the Congressionally Directed Medical Research ... The Hydrocephalus Association (HA), working in conjunction with its ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... - Before Congress takes its traditional August break, the ... human embryonic stem cell research. Let's hope a scientifically sound ... as Wisconsin follow the lead. , ,Just as Republicans in ... are GOP leaders in Washington, where President Bush suffered a ...
... Companies that are trying to justify RFID investment wholly ... efficiencies, and shrinkage in their supply chain are merely ... significant opportunities in these areas, it means that gross ... can achieve major improvements even without applying RFID. , ...
... MILWAUKEE - A group of business and technology ... $2.6 million in pledged state funds for the ... collaboration between academic researchers and private industry in southeastern ... Finance Committee by a margin of 15-1, and endorsed ...
Cached Biology Technology:Stem cell debate in Washington grows hotter as summer recess nears 2Stem cell debate in Washington grows hotter as summer recess nears 3The key to finding RFID's ROI 2The key to finding RFID's ROI 3The key to finding RFID's ROI 4Budget axe could cut SE Wisconsin tech alliance funding 2Budget axe could cut SE Wisconsin tech alliance funding 3
dynactin 4, mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
RABBIT ANTI HUMAN TRRAP (CT) Immunogen: Recombinant C-terminal kinase-related domain of human TRRAP....
One-step, microplate or cuvet, colorimetric, detection range 0.01 g/dL to 5 g/dL. Procedure: 5 min....
RABBIT ANTI HUMAN CHYMOTRYPSIN...
Biology Products: