Navigation Links
Cystic Fibrosis Foundation funds Marshall research
Date:3/28/2011

HUNTINGTON, W.Va. The Cystic Fibrosis Foundation has awarded a Marshall University scientist a two-year, $194,400 grant.

The grant to Dr. Hongwei Yu, professor in the Department of Biochemistry and Microbiology at the university's Joan C. Edwards School of Medicine, will help further his lab's work to explore the factors that control the overproduction of mucus in the lungs of cystic fibrosis (CF) patients.

According to Yu, chronic bronchial pneumonia caused by the bacterium Pseudomonas aeruginosa is a life-threatening condition for patients with CF.

"During these infections in CF patients, the bacterium is capable of producing copious amounts of alginatea thick, sugar-like polymer that plugs the airways, making breathing difficult," he said. "The alginate also helps form a thick, slimy 'biofilm' around the colonies of bacteria, protecting them from the body's immune defense mechanisms and making antibiotic treatment less effective."

Yu said the long-range goal of his research is to better understand the mechanisms of how this bacterium regulates production of the alginate biofilms in order to develop a more effective treatment option to inhibit or suppress the formation of alginate biofilms in the lungs of CF patients.

"For this project, we will be accessing the relevance of two newly identified proteins that act as alginate regulators. Once the mechanisms controlling alginate production are fully understood, it may be possible to improve treatment of these bacterial infections in CF patients by modulating or suppressing that production," he added.

Dr. John Maher, Marshall's vice president for research, congratulated Yu and praised him and his team for obtaining the grant.

"Dr. Yu's work is an excellent example of the vital research here at Marshall University that can affect the health and welfare of people everywhere. Research in his lab has the potential to have a real impact on the quality of life for people with cystic fibrosis," said Maher.

Maher also noted that Yu's research has had a regional economic development impact, saying his work has led to a patent and the development of Progenesis Technologies LLC, a West Virginia-based biotech research and development company. A second patent is pending.


'/>"/>

Contact: Ginny Painter
ginny.painter@marshall.edu
30-474-611-964
Marshall University Research Corporation
Source:Eurekalert  

Related biology news :

1. Pig model of cystic fibrosis improves understanding of disease
2. Breakthrough on cystic fibrosis 1 step closer as new research alliance formed
3. Women with polycystic ovary syndrome may be more vulnerable to BPA
4. Common diabetes drug may halt growth of cysts in polycystic kidney disease
5. 1 step closer to a drug treatment for cystic fibrosis, MU professor says
6. Drug may treat cystic fibrosis, other diseases caused by nonsense mutations, UAB researcher says
7. Research project yields better understanding of the defective protein that causes cystic fibrosis
8. Cystic fibrosis testing -- next steps
9. Two-pronged model could help foil tough cystic fibrosis infections
10. Nanoemulsion potent against superbugs that kill cystic fibrosis patients
11. New test promises quicker, more accurate evaluation for cystic fibrosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cystic Fibrosis Foundation funds Marshall research
(Date:5/24/2016)... -- Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the ... latest premium product recently added to the range of products distributed by Ampronix. ... ... ... Display- Ampronix News ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: