Navigation Links
Cynata Advances Development of Cymerus(TM) MSCs for the Treatment of Asthma
Date:3/2/2017

MELBOURNE, Australia, March 2, 2017 /PRNewswire/ -- Australian stem cell and regenerative medicine company, Cynata Therapeutics Ltd (ASX: CYP), has signed an agreement with the Monash Lung Biology Network, a consortia involving researchers from the Monash Biomedicine Discovery Institute and Department of Pharmacology at Monash University, Melbourne, to conduct a further preclinical study to support the use of Cymerus™ mesenchymal stem cells (MSCs) for the treatment of asthma. 

Asthma is a chronic, long term lung condition recognised by the World Health Organisation as a disease of major public health importance due to its global prevalence. Patients who suffer from chronic asthma manage the disease through the use of steroid type drugs, which can have significant side effects and impact on patients' quality of life. The global market for asthma drugs is expected to reach US$25.6 billion by 2024[1] so this challenging disease represents a highly valuable commercial opportunity for Cynata.

In October 2016, Cynata announced compelling initial data from a proof of concept study of Cymerus™ MSCs in an experimental model of asthma, which was conducted under the supervision of Associate Professor Chrishan Samuel and Dr Simon Royce at Monash University. Those initial results clearly demonstrated that Cymerus™ MSCs have a dramatic effect on improving airway hyper-responsiveness. Cynata recently received the final report of that study, which showed that Cymerus™ MSCs also consistently reduced markers of airway inflammation and airway remodelling. The preparation of a manuscript describing these findings is at an advanced stage, and it is expected to be submitted to a leading peer-reviewed journal in the near future.

Leading on from these findings, and consequent to the recent capital raising, the Company will now conduct a further study in collaboration with Associate Professor Samuel's group, which will focus on the effects of Cymerus™ MSCs in combination with and in comparison to corticosteroids.  This study has direct clinical relevance, as corticosteroids are the most widely used class of drugs currently used to control and/or prevent asthma exacerbations.

"Our findings so far are encouraging, in particular because Cymerus™ MSCs exerted effects that had not been seen with equivalent doses of human bone marrow-derived MSCs, or other stem cells, in the same model. We are therefore very pleased to be able to continue our collaboration with Cynata," said Associate Professor Samuel.

"The final report of the initial study at Monash has strengthened our confidence that Cymerus™ MSCs could exert substantial disease-modifying effects (rather than just treating the symptoms) in asthma, which is a very exciting prospect, given the large number of people who are unable to gain control of their asthma using existing drugs," said Cynata Vice President of Product Development, Dr Kilian Kelly. "We are optimistic that this accelerated program will pave the way forward for a clinical trial in asthma patients in the near future," added Dr Kelly.

[1] Grand View Research, Inc. Report, July 2016

CONTACTS:

Dr Ross Macdonald
CEO
Tel: +61 0412 119343
email: ross.macdonald@cynata.com

Rudi Michelson
Monsoon, Australia
Media Contact
Tel: +61 0411 402 737
email: rudim@monsoon.com.au

About Cynata Therapeutics (ASX: CYP)

Cynata Therapeutics Limited (ASX: CYP) is an Australian stem cell and regenerative medicine company that is developing a therapeutic stem cell platform technology, Cymerus™, originating from the University of Wisconsin-Madison, a world leader in stem cell research.  The proprietary Cymerus™ technology addresses a critical shortcoming in existing methods of production of mesenchymal stem cells (MSCs) for therapeutic use, which is the ability to achieve economic manufacture at commercial scale.  Cymerus™ utilises induced pluripotent stem cells (iPSCs) to produce a particular type of MSC precursor, called a mesenchymoangioblast (MCA).   The Cymerus™ platform provides a source of MSCs that is independent of donor limitations and provides an "off-the-shelf" stem cell platform for therapeutic product use, with a pharmaceutical product business model and economies of scale.  This has the potential to create a new standard in the emergent arena of stem cell therapeutics and provides both a unique differentiator and an important competitive position.

Monsoon Communications
Level 1, 121 William Street
Melbourne VIC 3000
Ph: +61 03 9620 3333
www.monsoon.com.au

This message and its attachments may contain legally privileged or confidential information. It is intended solely for the named addressee. If you are not the addressee indicated in this message (or responsible for delivery of the message to the addressee), you may not copy or deliver this message or its attachments to anyone. Rather, you should permanently delete this message and its attachments and kindly notify the sender by reply e-mail. No warranty is made that the e-mail or attachment(s) are free from computer virus or other defect.

If you wish to be removed from our contact list please send an email to info@monsoon.com.au immediately.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/cynata-advances-development-of-cymerustm-mscs-for-the-treatment-of-asthma-300416530.html


'/>"/>
SOURCE Cynata
Copyright©2017 PR Newswire.
All rights reserved


Related biology news :

1. Maverix Advances The State Of Gene Expression Analysis With Debut Of The Maverix RNA-Seq 3.0 Analysis Kit
2. Marvin Test Solutions GENASYS Platform Advances Mission-Critical Aerospace Production Test
3. Yale journal explores advances in sustainable manufacturing
4. Advances in assisted reproduction create more options & new legal issues for LGBT couples
5. Recent advances in stem cell biology
6. UF study advances DNA revolution, tells butterflies evolutionary history
7. Study: Marine pest provides advances in maritime anti-fouling and biomedicine
8. Science and technology advances in microbial forensics needed to better prepare
9. AGA unveils latest advances in GI research at DDW 2014
10. AGA unveils latest advances in GI research at DDW® 2014
11. Fly meeting to spotlight research advances in genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/23/2017)... Mar. 23, 2017 Research and Markets has ... Analysis & Trends - Industry Forecast to 2025" report to ... ... a CAGR of around 8.8% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... , June 28, 2017 Spectrecology LLC has ... their STEM education and research dollars. The program is ... latest fiber optic spectroscopy and photonics equipment despite current ... Innovations in Spectroscopy ... of equipment purchases used for the classroom or research. ...
(Date:6/28/2017)... ... 28, 2017 , ... Ovation Fertility continues to ... presentation at the 33rd Annual Meeting of the European Society of Human ... world’s top thought leaders in reproductive medicine – are expected to attend the ...
(Date:6/28/2017)... MO (PRWEB) , ... June 28, 2017 , ... Supplies ... panel of leading experts gathered at the Society of Nuclear Medicine and Molecular Imaging ... isotope of technetium-99m (Tc-99m), which is used in 30 to 40 million nuclear medicine ...
(Date:6/27/2017)... , ... June 27, 2017 , ... ... brain mirroring wellness product via Kickstarter campaign on June 15th to fund production ... pre-ordered the B2v2, exceeding the original Kickstarter goal by more than 150% in ...
Breaking Biology Technology: