Navigation Links
Curbing C. difficile's toxin production
Date:9/5/2007

dY activity, however, indicates to the bacteria that they are lacking key nutrients and that it is time to make the toxins they need to get food from the host cells.

To determine how CodY tells the bacteria not to make toxins, Sonenshein and colleagues removed DNA from the bacteria, and observed the interaction of the DNA and the CodY protein in vitro. They found that CodY targeted the region of the bacterial chromosome that includes the toxin genes. When CodY senses that the cell has enough nutrients, it binds to this gene region, and prevents the bacterium from making toxin, says Sonenshein. Conversely, when food is scarce, the CodY protein does not bind to these genes, allowing C. difficile to make the toxins needed to attack intestinal cells.

Knowing what turns on, and more importantly, what turns off the toxin-producing genes in C. difficile opens the door for treatment and prevention options. It is possible that, based on our findings, a new drug could be developed that would trick CodY into thinking there is enough fuel for the bacteria, causing CodY to remain bound to the toxin gene region and thus suppressing toxin production.


'/>"/>

Contact: Siobhan Gallagher
Siobhan.Gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Defensins neutralize anthrax toxin
2. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
3. Tetanus toxin found to have therapeutic properties
4. Structures of marine toxins provide insight into their effectiveness as cancer drugs
5. Prenatal exposure to marine toxin causes lasting damage
6. UCSD study finds anthrax toxins also harmful to fruit flies
7. Scientists design potent anthrax toxin inhibitor
8. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
9. Scientists reveal how deadly toxin hijacks cells
10. Scientists develop a way to make the deadliest toxin known even more toxic
11. Yale researchers find environmental toxins disruptive to hearing in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2009)... Ivy Pike, an associate professor of anthropology at the ... rural northern Kenya to understand how violence shapes the ... The results of her and her colleagues, research," Documenting ... communities of northern Kenya: A conceptual framework," is currently ... and Medicine , in collaboration with the British medical ...
(Date:12/11/2009)... Keystone Symposia on Molecular and Cellular Biology is ... Keystone Symposia Fellows for 2010. Launched in 2008, ... scientists (postdoctoral trainees or assistant professors) to shadow ... year. Fellows are selected based on their research ... diversity in the biomedical and life sciences. As ...
(Date:12/11/2009)... available in German . , ... plant introductions than extinctions, plant communities of many ... species are occurring more frequently, whereas rare species ... biological communities that are becoming increasingly similar, but ... have led to a loss of uniqueness among ...
Breaking Biology News(10 mins):UA-led study grapples with health effects of low-intensity warfare 2Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 2Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 3Keystone Symposia appoints 5 Fellows as part of diversity in life science initiative 4Europe's flora is becoming impoverished 2Europe's flora is becoming impoverished 3Hospira Reports Second Quarter 2009 Results 53042 1Hospira Reports Second Quarter 2009 Results 53042 2Hospira Reports Second Quarter 2009 Results 53042 3Hospira Reports Second Quarter 2009 Results 53042 4Hospira Reports Second Quarter 2009 Results 53042 5Hospira Reports Second Quarter 2009 Results 53042 6Hospira Reports Second Quarter 2009 Results 53042 7Hospira Reports Second Quarter 2009 Results 53042 8Hospira Reports Second Quarter 2009 Results 53042 9Hospira Reports Second Quarter 2009 Results 53042 10Hospira Reports Second Quarter 2009 Results 53042 11Hospira Reports Second Quarter 2009 Results 53042 12Hospira Reports Second Quarter 2009 Results 53042 13Hospira Reports Second Quarter 2009 Results 53042 14Hospira Reports Second Quarter 2009 Results 53042 15Hospira Reports Second Quarter 2009 Results 53042 16Hospira Reports Second Quarter 2009 Results 53042 17Hospira Reports Second Quarter 2009 Results 53042 18Hospira Reports Second Quarter 2009 Results 53042 19Hospira Reports Second Quarter 2009 Results 53042 20Hospira Reports Second Quarter 2009 Results 53042 21Hospira Reports Second Quarter 2009 Results 53042 22Hospira Reports Second Quarter 2009 Results 53042 23Hospira Reports Second Quarter 2009 Results 53042 24Hospira Reports Second Quarter 2009 Results 53042 25Hospira Reports Second Quarter 2009 Results 53042 26Hospira Reports Second Quarter 2009 Results 53042 27Hospira Reports Second Quarter 2009 Results 53042 28STAAR Surgical to Present at BMO Capital Markets 9th Annual Focus on Healthcare Conference in New York 53040 1HCA Reports Second Quarter 2009 Results 53037 1HCA Reports Second Quarter 2009 Results 53037 2HCA Reports Second Quarter 2009 Results 53037 3HCA Reports Second Quarter 2009 Results 53037 4HCA Reports Second Quarter 2009 Results 53037 5HCA Reports Second Quarter 2009 Results 53037 6HCA Reports Second Quarter 2009 Results 53037 7HCA Reports Second Quarter 2009 Results 53037 8HCA Reports Second Quarter 2009 Results 53037 9HCA Reports Second Quarter 2009 Results 53037 10HCA Reports Second Quarter 2009 Results 53037 11HCA Reports Second Quarter 2009 Results 53037 12HCA Reports Second Quarter 2009 Results 53037 13HCA Reports Second Quarter 2009 Results 53037 14
... (9-14-07) Oxidative stress is known to underlie many ... A team of scientists from Boston College has found ... stress plays in the development of diseases by studying ... the oxidative stress response has come primarily from studies ...
... system police are as good at recognizing bad guys, such ... researchers say. , The finding may cause a stir in ... cells or Tregs, preferentially respond to body proteins, or self ... bacteria. , Now, Medical College of Georgia immunologists report ...
... the 2007 American Society for Microbiology (ASM) ICAAC ... Inc., U.S. Human Health, will be presented to ... Child Health and Human Development (NICHD), Bethesda, Maryland. ... research excellence in microbiology and infectious disease. ...
Other Biology News:Boston College profs study oxidative stress subcellular to discover its role in diseases 2Immune police recognize good and bad guys in the body 2Immune police recognize good and bad guys in the body 3
(Date:12/14/2009)... ThermoFab, a US-based thermoforming company, has completed the delivery of ... sheet metal to a plastic enclosure with a smaller footprint ... ... Shirley, MA (PRWEB) December 14, 2009 -- ThermoFab, a US-based ... Flow Tester – helping Brookfield move from sheet metal to ...
(Date:12/11/2009)... Dendreon Corporation (Nasdaq: DNDN ) announced today ... offering have exercised in full their option to ... at the public offering price of $24.75 per ... the size of the offering to an aggregate ... expects to receive net proceeds from the offering ...
(Date:12/11/2009)... Boston College researchers have observed the "hot electron" effect ... successfully harvested the elusive charges using ultra-thin solar cells, ... the authors report in the current online edition of ... captured in solar cells, it generates free electrons in ... snare these charges, the electrons must reach the bottom ...
(Date:12/11/2009)... Calif., Dec. 11 Marrone Bio Innovations ... executive management team. Mr. Chris Hildreth joined MBI ... is responsible for expanding all commercial aspects of ... functions. Dr. Kin Sing (Ray) Lam joined MBI ... the company,s development efforts in scaling its broad ...
Breaking Biology Technology:Thermofab Helps Brookfield Engineering Move To A Compact Custom Plastic Enclosure 2Dendreon Announces Exercise of Option by Underwriters in its Common Stock Offering 2Dendreon Announces Exercise of Option by Underwriters in its Common Stock Offering 3Elusive 'hot' electrons captured in ultra-thin solar cells 2Marrone Bio Innovations Announces Two New Executive Appointments 2Marrone Bio Innovations Announces Two New Executive Appointments 3
... Medical College of Wisconsin has implemented IBM s ... infrastructure support system for proteomics research. IBM announced last month ... on Power Architecture will begin shipping in volume globally ... site to test the Sequest application on the JS20 running ...
... MADISON Advances in the development of healthcare ... electronic healthcare. Although the technology exists, organizations often ... systems to a more efficient and safer digital ... Leveraging Information Technology to Improve Patient Safety and ...
... Now that Gov. Jim Doyle has signed a bill ... states technology sector blossom like a spring flower? , ,Based ... creation of tax credits for angel and early-stage investments as ... news, but its only one step toward easing Wisconsins chronic ...
Other Biology Technology:Medical College of Wisconsin enhances research with IBM Blade server 2UW symposium to explore impact of IT on improving quality, safety and cost of healthcare 2Investment tax credit bill is a good start, but Wisconsin must confront other barriers to capital formation 2Investment tax credit bill is a good start, but Wisconsin must confront other barriers to capital formation 3
D4-GDI rabbit polyclonal antibody...
Mouse monoclonal [SPM217] to Secretory Component Glycoprotein ( Abpromise for all tested applications)....
Rabbit polyclonal to FLIP ( Abpromise for all tested applications). entrezGeneID: 8837 SwissProtID: O15519...
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Biology Products: