Navigation Links
Curbing C. difficile's toxin production
Date:9/5/2007

BOSTON (Sept. 5, 2007) As if being admitted to the hospital werent bad enough, patients, once admitted, are at higher risk of becoming infected with a superbug bacterium, Clostridium difficile (C. difficile). The toxins produced by C. difficile kill human intestinal cells by causing them to burst open, allowing the bacteria to use them as fuel. This results in severe diarrhea and, in rare cases, death. Abraham Linc Sonenshein, PhD, and colleagues from the Department of Molecular Biology and Microbiology at the Tufts University School of Medicine (TUSM) and the Sackler School of Graduate Biomedical Sciences at Tufts, have discovered how a protein called CodY regulates the genes that control production of the dangerous toxins. Understanding the relationship between CodY and C. difficile is an important step toward the development of a drug that may prevent hospital patients from falling ill.

The C. difficile bacteria only produce toxins when they are in need of food, explains Sonenshein, professor of microbiology at TUSM and corresponding author on the paper to be published in Molecular Microbiology. We found that the CodY protein, in essence, monitors the hunger level of C. difficile, preventing toxin production when the bacteria have enough to eat. Sonenshein, along with first author Sean Dineen, PhD, and other Tufts colleagues developed a series of experiments to investigate the importance of CodY and how this protein communicates to bacteria that it is time to search for new sources of food.

The researchers first developed a mutant strain of C. difficile bacteria that does not make the protein CodY, and compared the amount of toxin produced by the mutant strain of bacteria to the amount of toxin produced by normal bacteria. The mutant strain produced much higher levels of toxin. The presence of CodY seems to tell the bacterial cells that they are well-fed and there is no reason to make toxin that kills intestinal cells for fuel. Lack of Co
'/>"/>

Contact: Siobhan Gallagher
Siobhan.Gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Defensins neutralize anthrax toxin
2. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
3. Tetanus toxin found to have therapeutic properties
4. Structures of marine toxins provide insight into their effectiveness as cancer drugs
5. Prenatal exposure to marine toxin causes lasting damage
6. UCSD study finds anthrax toxins also harmful to fruit flies
7. Scientists design potent anthrax toxin inhibitor
8. Anthrax inhibitor counteracts toxin, may lead to new therapeutics
9. Scientists reveal how deadly toxin hijacks cells
10. Scientists develop a way to make the deadliest toxin known even more toxic
11. Yale researchers find environmental toxins disruptive to hearing in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Antonio Life Sciences Institute (SALSI), a joint venture between ... The University of Texas Health Science Center at San ... Pilot Program. The winners, Emily Boice from UTSA and ... $25,000 for their project titled, "Novel engineered ferritins for ... , Boice and Huang,s research is focused on finding ...
(Date:7/30/2014)... be as simple as inserting a medicated, disappearing fabric ... bioengineers have discovered a potentially faster way to deliver ... Their method spins the drug into silk-like fibers that ... doses of the drug than possible with other topical ... offer women a potentially more effective, discreet way to ...
(Date:7/30/2014)... out how to create colors, nature had already perfected ... many different hues, for example. Now scientists are tapping ... way to make colored plastics. Their paper on using ... rather than dyes, to produce color appears in ... Asger Mortensen, Anders Kristensen and colleagues point out that ...
Breaking Biology News(10 mins):Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... release is available in German . ... in the atmosphere where it contributes to global warming. The ... as forests, grasslands and peat-lands. Stimulating this "free service" of ... immediately available ways of reducing climate change. However, new greenhouse ...
... inventoried an astonishing abundance, diversity and distribution of deep sea ... manage a living in a frigid black world down to ... Revealed via deep-towed cameras, sonar and other vanguard technologies, animals ... 17,650, a diverse collection of species ranging from crabs to ...
... MA November 23, 2009 Agios Pharmaceuticals today ... time, that the mutated IDH1 gene has a novel ... This breakthrough discovery shows that the mutated form of ... to the formation and malignant progression of gliomas, the ...
Cached Biology News:Intensive land management leaves Europe without carbon sinks 2Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 2Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 3Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 4Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 5Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 6Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 7Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 8Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 9Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 2Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 3Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer 4
(Date:7/31/2014)... , July 31, 2014 Research and ... "Global Genomics Market 2014-2018" report to their offering. ... Genomics is the study of the genetic material or ... a strong basis for the discovery and development of ... diseases or health conditions. Genomics is supported by three ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: ... taste science technologies to discover, develop, and commercialize ... ingredient supply industries, today reported financial results for ... second quarter with $33.6 million in cash and ... past quarter Senomyx achieved another important milestone with ...
(Date:7/31/2014)... SHENZHEN, China , July 31, 2014 /PRNewswire/ ... of an Irys™System by BGI , ... to enable comprehensive exploration of human structural variation (SV) ... of interest, including those where no reference exists. In ... new methods for multiplexing on the Irys System, enabling ...
(Date:7/31/2014)... Rancho BioSciences , the scientific ... Array Suite with tranSMART . Scientists that ... send data in tranSMART to Array Suite for further ... tranSMART including the new 1.2 release. Array Suite ... for the analysis of high dimensional quantification data, including ...
Breaking Biology Technology:Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3
... FORTUNE,S 100 Fastest-Growing Companies, List -- SHANGHAI, Aug. 26 /PRNewswire-Asia-FirstCall/ -- ... ... ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
... Hikma - Half Year Results Interviews With CEO and CFO -- LONDON, August 26, 2010 ... ... ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. ...
... bag of potato chips or pop in a DVD, you,re probably ... soap. Sputter deposition is an industrial process used since the ... various backings, like the metallic coating on potato chip bags, the ... Mostly, the process works very well. In a vacuum chamber filled ...
Cached Biology Technology:China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 2China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 3China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 4China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 5China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 6China-Biotics Ranked Number 62 on FORTUNE'S 100 Fastest-Growing Companies' List 7Hikma - Half Year Results Interviews With CEO and CFO 2Hikma - Half Year Results Interviews With CEO and CFO 3Hikma - Half Year Results Interviews With CEO and CFO 4Hikma - Half Year Results Interviews With CEO and CFO 5Trouble with sputter? Blame giant nanoparticles 2Trouble with sputter? Blame giant nanoparticles 3
casein kinase 2, alpha 1 polypeptide, transcript variant 2, mRNA (cDNA clone MGC:15232 IMAGE:4121882), complete cds...
...
UV LAMP 300 NM 8W T5, 1 EA. Category: Nucleid Acid Detection Systems....
MOUSE ANTI S. MUTANS PEPTIDOGLYCAN...
Biology Products: