Navigation Links
Crystal structure shows how motor protein works
Date:9/18/2011

The crystal structure of the dynamin protein one of the molecular machines that makes cells work has been revealed, bringing insights into a class of molecules with a wide influence on health and disease.

"It's a really cool structure," said Jodi Nunnari, professor and chair of molecular and cellular biology at UC Davis and senior author of the paper, to be published Sept. 18 in the journal Nature. "This is a really important class of molecules for regulating membrane dynamics."

The detailed structure reveals exactly how the dynamin protein can form large assemblies that pinch off bubbles, or vesicles, from cell membranes. These vesicles allow a cell to "eat" proteins, liquids or other items from the outside, compartmentalize them and move them around within itself.

Marijn Ford, a postdoctoral scholar in Nunnari's laboratory, mapped the crystal structure of dynamin-1 in collaboration with Simon Jenni, a research fellow at Harvard University.

Dynamin belongs to a large family of proteins that, in the right conditions, can self-assemble into larger structures and generate force. Those properties of self-assembly and movement can be harnessed in the cell for different functions.

Dynamin-1 itself is involved in making vesicles in nerve cells at the points where nerves form connections, or synapses, with each other. Nerve cells communicate through chemical messengers (neurotransmitters) that are released from and taken up by vesicles. Altering the balance of these messengers can affect mental function. For example, an important class of antidepressant drugs works by affecting the uptake of the neurotransmitter serotonin.

The new crystal structure shows exactly how the individual dynamin proteins can line up to form a helix, and then move by ratcheting alongside each other.

It also shows that part of the protein can interact with lipids in cell membranes. That could allow different types of dynamin protein to interact with subtly different types of membrane, specializing their function.

Understanding these miniature motors also might make it possible one day to engineer cells that can do new and different tasks, Nunnari said.


'/>"/>
Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Related biology news :

1. Crystals detect threats to national security
2. Nano-diamond qubits and photonic crystals
3. Quartz crystal microbalances enable new microscale analytic technique
4. X-ray crystallography reveals structure of precursor to blood-clotting protein
5. New type of liquid crystal promises to improve performance of digital displays
6. How do your crystals grow?
7. A crystal ball for predicting the effects of global climate change
8. Cholesterol crystals incite inflammation in coronary arteries
9. Ancestral Eve crystal may explain origin of lifes left-handedness
10. Researchers envision high-tech applications for multiferroic crystals
11. Scientists watch as peptides control crystal growth with switches, throttles and brakes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
Breaking Biology Technology: