Navigation Links
Crowd-sourcing the E. coli O104:H4 outbreak
Date:9/4/2011

Ten variants of the deadly Escherichia coli strain that hit Germany in May 2011 have been sequenced across the world. The unprecedented level of collaboration across the scientific community should give insight into how the outbreak arose, says a scientist at the Society for General Microbiology's Autumn Conference 2011.

Sequencing of the bacterium started in early June at BGI, China. Their sequence was provided in draft form to the scientific community as a crowd-sourcing project. This allowed scientists, including those at The Genome Analysis Centre (TGAC) in Norwich to identify key disease-causing genes. Dr Lisa Crossman, Microbial Genome Project Leader at TGAC, explained, "We have found that the E. coli strain responsible for the outbreak carries a very high number of genes known to be involved in disease. These include genes that influence the bacterium's ability to attach to surfaces and survival genes that increase tolerance to high acidity, low oxygen, UV light and antibiotics."

The outbreak of E. coli O104:H4 resulted in a large number of cases of bloody diarrhoea and haemolytic uraemic syndrome (HUS) in Germany, and in 15 other countries in Europe and North America. The earliest studies suggested contaminated cucumbers were to blame. However by 10 June, raw beansprouts were identified as the source of infection. Over 4,000 cases and around 50 deaths have occurred so far across 16 countries in Europe and North America. The outbreak has also had a very high economic impact on the fresh vegetable market, especially in Spain and across Europe.

Crowd-sourcing researchers found that the outbreak strain is most closely related to a strain of E. coli originally isolated in Central Africa some years ago, which was responsible for cases of serious diarrhoea. "The E. coli O104:H4 outbreak strain has gained the ability to make a toxin from a bacterial virus source which has made it more dangerous," explained Dr Crossman.

The unprecedented global crowd-sourcing effort meant that in the very immediate term, doctors were able to distinguish this strain from others, said Dr Crossman. "Knowing which antibiotic resistance genes are carried by the strain, for example, can provide us with more insight into the source of the outbreak and help us avoid similar outbreaks occurring in the future," she said.

Institutions around the world have now isolated ten different variants of E. coli O104:H4. "These variants represent a tremendous resource to examine this bug in a new, rapid and exciting way. By studying the genetic factors involved in the survival of this bacterium on surfaces, we hope to get an angle on how this organism has been able to get a foothold in the global food chain," suggested Dr Crossman.


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related biology news :

1. Researchers uncover source of Haitian cholera outbreak
2. TGen and DTU researchers track source of Haitian cholera outbreak
3. Two isolates from E. coli outbreak available
4. Genomics and social network analysis team up to solve disease outbreaks
5. Forecast system to warn of toxic algal outbreaks along Texas shoreline
6. Risk of beetle outbreaks rise, along with temperature, in the warming West
7. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
8. Cold fronts linked to European H5N1 outbreaks
9. Rapid response team investigates coral disease outbreak in Kaneohe Bay, Oahu
10. Hygienic Lab at U. Iowa first to confirm salmonella in nationwide outbreak
11. Scientists decoding genomic sequences of H1N1 using isolates from outbreak in Argentina
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Crowd-sourcing the E. coli O104:H4 outbreak
(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
(Date:10/9/2017)... Antonio, Texas (PRWEB) , ... ... ... new study published on October 5, 2017, in the medical journal, Epilepsia, ... equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic seizures ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially ... cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, ...
Breaking Biology Technology: