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Cross-country runabouts -- immune cells on the move
Date:11/17/2009

issues and thus form a connection to the outside world. "The connection between the cytoskeleton and the integrin matches the clutch, the connection between the integrin and the outside world corresponds to the grasp of the wheels." says Dr. Sixt.

Immune cells are cross-country capable

In doing so, immune cells are not rigid and inflexible. According to the scientists, they are able to adjust to every possible substrate. "Our analysis has shown that leukocytes always move with the same speed - no matter whether they migrate over a slippery or rough substrate," Dr. Sixt points out. That is possible due to the tight interaction between motor, clutch and wheels. When the cell's anchors do not grip properly, the cell increases the speed of its engine - the cytoskeleton deforms faster. Thus, the speed of the cell stays the constant. Leukocytes are also able to overcome locally occurring unevenness. Should the immune cell move with one half over slippery and with the other on rough ground, the cytoskeleton adjusts locally - similar to a differential gear. "Thus, the direction of movement is defined only by the attractant," explains the physician. "And this attractant limits itself as little as the leukocyte with regard to tissue frontiers and unevenness of the substrate.


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Contact: Dr. Michael Sixt
sixt@biochem.mpg.de
Max-Planck-Gesellschaft
Source:Eurekalert  

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