Navigation Links
Cross-country collaboration leads to new leukemia model
Date:7/31/2013

the California Institute for Regenerative Medicine (CIRM). The meetings, which began in 2005 and have continued, require all registrants to keep presentations no longer than 15 minutes and only to discuss unpublished work. "It's sort of Las Vegas rules," Wagers said.

At the second such meeting, Passegu was intrigued by Wagers' cell isolation-based approach to studying the bone marrow niche, the environment where stem cells are found. In the ensuing years, the two scientists swapped protocols, chemical reagents, mice, and even postdoctoral researchers in the pursuit of discovering what causes healthy blood cell dysfunction in leukemia. "Wagers was really involved as a creative spirit in the development of this story," Passegu said.

The observation that leukemia cells can remodel the bone marrow niche parallels work done by HSCI co-director David Scadden of the Harvard-affiliated Massachusetts General Hospital, who demonstrated that particular genetic modifications of bone-forming cells initiate changes in the marrow cavity that suppress normal blood formation and promote the emergence of leukemic cells. "So there's this bidirectional communication that's self-reinforcing, "Wagers said. "And if there's a communication loop like that, you can think about interrupting in many different ways."

Passegu wants to understand how bone-marrow support cells are manipulated to sustain leukemia cells, instead of normal blood cells, in order to design therapies that block these detrimental changes. In the short term, her work could explain why 75 percent of bone marrow transplants are unsuccessful. "A poor niche is likely a very important contributing factor for failure to engraft," she said. Her lab has shown that fibrotic bone marrow conditions can be reversed in as little as a few months by removing the bad-acting maintenance cells, and she is now investigating how to restore the healthy bone marrow environment in leukemia patients.

Passegu
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute continues longtime collaboration with Kyowa Hakko Kirin California
2. Ben-Gurion U. and UChicago research collaboration targets water resource innovations
3. NIH to fund collaborations with industry to identify new uses for existing compounds
4. First international collaboration to showcase latest body of evidence of dairy health benefits
5. Missouri Botanical Garden program announces collaboration with LHerboretum
6. Missouri Botanical Garden program annouces collaboration with LHerboretum
7. Collaboration to establish new computational resources for metabolomics
8. Oregon Biodiversity Information Center wins 2013 Natureserve Network Collaboration Award
9. Nottingham-Australia collaboration on environmental conservation of the future
10. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
11. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... of the "Access Control Market by Product, Application ... 2020" report to their offering. , ... expected to reach $10.4 billion by 2020, with an ... market report covers the products types such as contact ...
(Date:3/10/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce ... been named the "Number One Best Tech Gift ... Modern ( http://www.rethinkmodern.com/ ) is a web magazine focused ... that have a unique function or design.  ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... Ice Age bones indicate that humans in Ohio hunted or ... curator of archaeology at The Cleveland Museum of Natural History, ... 2012 online issue of the journal World Archaeology . ... 1998 in the collections of the Firelands Historical Society Museum ...
... University biologists have found that specific types of RNA polymerase ... differ in function based on variation in the parts -- ... machines. The new findings on the synthesis and function ... lead author Craig Pikaard discovered over a decade ago -- ...
... Probing the largely unexplored question of what characteristics ... that by mimicking nature, a robotic fish can transform ... series of experiments, researchers from Polytechnic Institute of New ... animal behavior, including learning how robots might someday steer ...
Cached Biology News:Research reveals first evidence of hunting by prehistoric Ohioans 2IU biologists offer clearer picture of how protein machine systems tweak gene expression 2What makes a robot fish attractive? (Hint: It's in the moves) 2
(Date:3/26/2015)... 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ... advanced testing solutions for the detection of foodborne ... three months and full year ended December 31, ... for the quarter ended December 31, 2014 was ... quarter of 2013 and $1.5 million for the ...
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 ReliantHeart, Inc., ... and Transonic, a supplier of precision transit-time flow measurement ... will greatly improve the efficiency of the HeartAssist5® ... LVAD patients to experience greater mobility and peace of ... the miniature flow board, will draw 1/6th of the ...
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... Inc. (Nasdaq: BIOD ) today reported financial results ... Third Quarter Operating Highlights During Biodel,s third ... completed Phase 1 testing of two new ultra-rapid-acting formulations of ... supported investigators at Oregon Health and Sciences University who have ...
... 4, 2011 Vermillion, Inc. (NASDAQ: ... for the second quarter ended June 30, 2011. Key milestones we ... Performance of an estimated 3,920 OVA1® tests during ... 3,200-3,500 tests and representing volume growth of 27% over the ...
... carbon nanofiber-filled coatings devised by researchers from the National ... University outperformed conventional flame retardants used in the polyurethane ... 160 percent and perhaps by as much as 1,130 ... journal Polymer ,* suggest that significant fire-safety advantages ...
Cached Biology Technology:Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 2Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 3Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 4Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 5Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 6Vermillion Reports Results for the Second Quarter 2011 2Vermillion Reports Results for the Second Quarter 2011 3Vermillion Reports Results for the Second Quarter 2011 4Vermillion Reports Results for the Second Quarter 2011 5Vermillion Reports Results for the Second Quarter 2011 6Vermillion Reports Results for the Second Quarter 2011 7Novel coatings show great promise as flame retardants in polyurethane foam 2
... RQ1 RNase-Free DNase is a ... single-stranded or double-stranded DNA to produce ... for use in applications where maintaining ... RQ1 DNase is qualified for use ...
... Wild Type Liquid. In 100 mM ... µM EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW ... a monomeric protein of 765 amino acids encoded ... of both positive and negative supercoiled DNAs without ...
Request Info...
... III digests duplex DNA in a 3'-> ... or nick, producing stretches of single-stranded DNA. ... Exonuclease III proceeds at a uniform rate ... rate of exonucleolytic excision of deoxyribonucleotides by ...
Biology Products: