Navigation Links
Cross-country collaboration leads to new leukemia model
Date:7/31/2013

the California Institute for Regenerative Medicine (CIRM). The meetings, which began in 2005 and have continued, require all registrants to keep presentations no longer than 15 minutes and only to discuss unpublished work. "It's sort of Las Vegas rules," Wagers said.

At the second such meeting, Passegu was intrigued by Wagers' cell isolation-based approach to studying the bone marrow niche, the environment where stem cells are found. In the ensuing years, the two scientists swapped protocols, chemical reagents, mice, and even postdoctoral researchers in the pursuit of discovering what causes healthy blood cell dysfunction in leukemia. "Wagers was really involved as a creative spirit in the development of this story," Passegu said.

The observation that leukemia cells can remodel the bone marrow niche parallels work done by HSCI co-director David Scadden of the Harvard-affiliated Massachusetts General Hospital, who demonstrated that particular genetic modifications of bone-forming cells initiate changes in the marrow cavity that suppress normal blood formation and promote the emergence of leukemic cells. "So there's this bidirectional communication that's self-reinforcing, "Wagers said. "And if there's a communication loop like that, you can think about interrupting in many different ways."

Passegu wants to understand how bone-marrow support cells are manipulated to sustain leukemia cells, instead of normal blood cells, in order to design therapies that block these detrimental changes. In the short term, her work could explain why 75 percent of bone marrow transplants are unsuccessful. "A poor niche is likely a very important contributing factor for failure to engraft," she said. Her lab has shown that fibrotic bone marrow conditions can be reversed in as little as a few months by removing the bad-acting maintenance cells, and she is now investigating how to restore the healthy bone marrow environment in leukemia patients.

Passegu
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute continues longtime collaboration with Kyowa Hakko Kirin California
2. Ben-Gurion U. and UChicago research collaboration targets water resource innovations
3. NIH to fund collaborations with industry to identify new uses for existing compounds
4. First international collaboration to showcase latest body of evidence of dairy health benefits
5. Missouri Botanical Garden program announces collaboration with LHerboretum
6. Missouri Botanical Garden program annouces collaboration with LHerboretum
7. Collaboration to establish new computational resources for metabolomics
8. Oregon Biodiversity Information Center wins 2013 Natureserve Network Collaboration Award
9. Nottingham-Australia collaboration on environmental conservation of the future
10. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
11. Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
(Date:10/16/2014)... have a new synthesis of recent research findings to ... in the two states. , The Ecology and ... Washington: A Synthesis of the Relevant Biophysical Science and ... published by the U.S. Forest Service,s Pacific Northwest Research ... managers for a synthesis of the large body of ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... causes those painful lip blisters known as cold sores has an ... it to literally blast its infectious DNA into human cells, scientists ... mechanism the first in a human virus opens the ... study in the Journal of the American Chemical Society . ...
... revealed new images which provide the clearest picture yet ... and tumours. , They show how the cells, which ... human body, change the organisation of their surface molecules, ... viral-infected or tumour cells., Professor Daniel Davis, who has ...
... HUNTSVILLE, Ala -- Even in the absence of a ... and intellectual challenges is helpful to physicians and families. ... high throughput genomic sequencing to meet major diagnostic needs ... totaling more than $7.6 million from the National Institutes ...
Cached Biology News:Researchers reveal the clearest new pictures of immune cells 2HudsonAlpha awarded grant to improve diagnoses of childhood genetic disorders 2
(Date:10/20/2014)... 20, 2014 PureTech , a science ... healthcare problems, announced today the closing of a ... from Invesco Perpetual, a $120 Billion group of ... PureTech,s existing pipeline forward and to advance new ... scientific creativity to really go for the big ...
(Date:10/20/2014)... October 20, 2014 Earle ... LLC, announced today that Ellen Teplitzky, an experienced ... for the pharmaceutical industry, has joined the firm ... its legal services practice. NDA Partners provides ... witness and testimony, to top law firms and ...
(Date:10/19/2014)... 19, 2014 The Latin American hardware ... in Latin America with analysis and forecast of revenue. ... and is expected to reach $2,366.8 million by 2018, ... , Browse through the TOC of the Latin American ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... 2014 NextCODE Health, which enables clinicians and researchers ... time, today announced the launch of its new genomic data ... the American Society of Human Genetics (ASHG) annual meeting in ... up and apply for free beta access, visit www.nextcode.com ... can be viewed here . The Exchange: ...
Breaking Biology Technology:PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... Conn., Aug. 25, 2011 Advanced BioHealing, ... medicine therapies, today announced that it ranked in the ... list of America,s fastest-growing, privately held companies. ... at a vital segment of the U.S. economy—America,s independent-minded ...
... major impact on future nanoscale device design, such as ... size, many materials like silicon are as brittle as ... compressed into half their size without breaking them. The ... led by Professor Roman Nowak. Atom by atom, ...
... Aug. 24, 2011 Bacterin International Holdings, Inc. ... development of revolutionary bone graft material and antimicrobial coatings for ... Nicolaus 2011 Healthcare Conference. The conference will be held at ... 2011. Bacterin,s chairman and CEO, Guy Cook, and ...
Cached Biology Technology:Advanced BioHealing Named to Prestigious Inc. 500 List of America's Fastest Growing Private Companies 2Bacterin International to Present at Stifel Nicolaus 2011 Healthcare Conference on September 8, 2011 2
... Bio-Beads SM-2 adsorbents are macroporous polystyrene beads ... high surface area for adsorbing organics of ... solutions. The beads are useful for the ... agents; for example, the removal of detergents ...
... Immunogen : Fusion protein corresponding ... of human Mi-2 Formulation: 0.7M ... 0.035% sodium azide, containing 30% ... by immunoblot on Hela nuclear ...
... Anti-MAPKAPK-2, Phospho-Specific(Thr ... In 150 mM NaCl, 10 ... BSA, 50% glycerol, pH 7.5. ... kinase-activated protein kinase 2 (MAPKAPK-2) ...
...
Biology Products: