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Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
Date:3/26/2012

s an important medication that helps get high-risk patients to recommended treatment targets" said Russ Esterline, VP Global Product Development Cardiovascular, AstraZeneca. "Additionally, these favourable results add to the wealth of data that demonstrate CRESTOR is well positioned in the market to remain a statin of choice for physicians treating patients at increased-risk."

Guidelines continue to stress the importance of achieving aggressive LDL-C treatment goals in higher risk patients and the important role of statins in achieving these goals. Under the recently updated ESC/EAS guidelines, target LDL-C goals have become more stringent, particularly for patients with established cardiovascular disease, type II diabetes and for other patients classified as being at very high risk of a primary or secondary cardiovascular event.The ESC/EAS guidelines recommend that clinicians should aim for LDL-C levels below <3.0 mmol/L (~115 mg/dL) in moderate risk patients, <2.5 mmol/L (~100 mg/dL) in high-risk patients and <1.8 mmol/L (~70 mg/dL) and/or at least 50 percent reduction in levels if this target cannot be reached in very high-risk patients.

CRESTOR has been researched extensively for over 13 years, including 120 clinical trials of more than 67,000 patients worldwide from more than 55 countries.

NOTES TO EDITORS

VOYAGER (An indiVidual patient data meta-analysis Of statin therapY in At risk Groups: Effects of Rosuvastatin, atorvastatin and simvastatin) is a unique individual patient data  meta-analysis of 32 258 patients from 37 randomised studies comparing the lipid modifying effects of rosuvastatin with that of atorvastatin and simvastatin. The patients include almost 9,000 with diabetes and over 15,000 with atherosclerotic disease.

CRESTOR has now received regulatory approvals in over 109 countries. Worldwide, doctors ha
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SOURCE AstraZeneca
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