Navigation Links
Cracks in the cellular transport system can be key to a new generation of cancer therapies

Researchers from Warwick Medical School have discovered a critical point of failure in the microscopic transport system that operates inside every cell in the human body.

The study, published today in Nature Communications, explains how this tiny 'railway' system is a key target for cancer drugs and, as such, how this new discovery reveals how better drugs might be made. The tracks of this so called 'railway' are tiny tubes, called microtubules, 1000 times thinner than a human hair.

The research shows that a narrow seam that runs along the length of the microtubules is the weakest point. If the seam cracks and splits, the microtubule dissolves.

It has been known for some time that microtubules have a single seam that zips the structure together along its length, but the function of this seam has evaded scientists until now. By building microtubules with extra seams in the laboratory, and examining their stability using video microscopes, the researchers found that the more seams the microtubule has, the more unstable it becomes.

The new work dramatically alters thinking on how the microtubule system works and the search is now on for factors inside the cell that influence the stability of microtubule seams.

Microtubules are a validated target for cancer therapy drugs. For example Taxol, used in breast cancer therapy, binds to microtubules and stops the microtubule from dissolving. This means the microtubule tracks cannot remodel themselves prior to cell division, which in turn stops the cells dividing, thus arresting the growth of cells including those forming cancerous tumours.

Professor Robert Cross, head of the research team at Warwick Medical School, explained, "It is clear that any new drugs aiming to stabilize or destabilize microtubules must target the microtubule seam. We expect this to lead us to a better understanding of the way microtubules are regulated in cells and why this sometimes goes wrong, such as in development of cancer."

"Our findings help us to understand how some existing cancer treatment drugs actually work and this in turn should lead to development of new generations of better and more effective anti-microtubule drugs."


Contact: Luke Harrison
University of Warwick

Related biology news :

1. Secret soil cracks linger, despite surface sealing
2. U of T-led study cracks universal RNA code, suggests a new cause for autism
3. Salk scientists open new window into how cancers override cellular growth controls
4. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
5. Cellular secrets of plant fatty acid production understood
6. Make or break for cellular tissues
7. A non-invasive intracellular thermometer with fluorescent proteins has been created
8. Groundbreaking discovery of the cellular origin of cervical cancer
9. BUSM study shows role of cellular protein in regulation of binge eating
10. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
11. Researchers study knee stress at tissue, cellular levels
Post Your Comments:
Related Image:
Cracks in the cellular transport system can be key to a new generation of cancer therapies
(Date:11/4/2015)... York , November 4, 2015 ... a new market report published by Transparency Market Research "Home ... Growth, Trends and Forecast 2015 - 2022", the global home ... US$ 30.3 bn by 2022. The market is estimated ... forecast period from 2015 to 2022. Rising security needs ...
(Date:10/29/2015)... Minn. , Oct. 29, 2015   MedNet ... supports the entire spectrum of clinical research, is pleased ... Minnesota High Tech Association (MHTA) as one of only ... in the "Software – Small and Growing" category. The Tekne ... individuals who have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... Calif. , Dec. 1, 2015 ... Transformational Health program. This program addresses ways companies ... of change. ... Logo - ... aspect of healthcare, as well as the disrupting ...
(Date:12/1/2015)... Dec. 01, 2015 ... of the "2016 Europe Cell Surface ... Technologies, Competitive Strategies, Opportunities for Suppliers--France, Germany, ... offering. --> ) has ... Europe Cell Surface Markers: Country Volume and ...
(Date:12/1/2015)... ... December 01, 2015 , ... RURO, Inc., ... selling system laboratory animal colony management software solution, ezColony®, is now available as ... IT resources., , Many organizations are moving to cloud-hosting ...
(Date:12/1/2015)... 1, 2015 Cepheid (Nasdaq: CPHD ) ... the Piper Jaffray Healthcare Conference in New ... is reaffirming its outlook for the fourth quarter of ... to discussing longer term business model expectations. ...  "We continue to be the fastest growing company of ...
Breaking Biology Technology: