Navigation Links
Cracks in the cellular transport system can be key to a new generation of cancer therapies
Date:1/27/2014

Researchers from Warwick Medical School have discovered a critical point of failure in the microscopic transport system that operates inside every cell in the human body.

The study, published today in Nature Communications, explains how this tiny 'railway' system is a key target for cancer drugs and, as such, how this new discovery reveals how better drugs might be made. The tracks of this so called 'railway' are tiny tubes, called microtubules, 1000 times thinner than a human hair.

The research shows that a narrow seam that runs along the length of the microtubules is the weakest point. If the seam cracks and splits, the microtubule dissolves.

It has been known for some time that microtubules have a single seam that zips the structure together along its length, but the function of this seam has evaded scientists until now. By building microtubules with extra seams in the laboratory, and examining their stability using video microscopes, the researchers found that the more seams the microtubule has, the more unstable it becomes.

The new work dramatically alters thinking on how the microtubule system works and the search is now on for factors inside the cell that influence the stability of microtubule seams.

Microtubules are a validated target for cancer therapy drugs. For example Taxol, used in breast cancer therapy, binds to microtubules and stops the microtubule from dissolving. This means the microtubule tracks cannot remodel themselves prior to cell division, which in turn stops the cells dividing, thus arresting the growth of cells including those forming cancerous tumours.

Professor Robert Cross, head of the research team at Warwick Medical School, explained, "It is clear that any new drugs aiming to stabilize or destabilize microtubules must target the microtubule seam. We expect this to lead us to a better understanding of the way microtubules are regulated in cells and why this someti
'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Secret soil cracks linger, despite surface sealing
2. U of T-led study cracks universal RNA code, suggests a new cause for autism
3. Salk scientists open new window into how cancers override cellular growth controls
4. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
5. Cellular secrets of plant fatty acid production understood
6. Make or break for cellular tissues
7. A non-invasive intracellular thermometer with fluorescent proteins has been created
8. Groundbreaking discovery of the cellular origin of cervical cancer
9. BUSM study shows role of cellular protein in regulation of binge eating
10. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
11. Researchers study knee stress at tissue, cellular levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cracks in the cellular transport system can be key to a new generation of cancer therapies
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
(Date:7/10/2014)... Colo. , June 27, 2014  The ... the National Institute of Standards and Technology (NIST) ... of its academic research and forensic science expert ... The Board is an element of the NIST,s ... members are among the first appointments made to ...
(Date:7/10/2014)... -- It is a great honor for Avery Biomedical ... world-renowned Thoracic and Cardiovascular surgeon, Mark E Ginsburg, M.D., ... with over 34 years of experience, is currently practicing ... Regional Medical Center. Dr. Ginsburg has been implanting the ... considered an expert in the implantation of the Avery ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
... big trouble for marine life, starting with the worms, say ... of Exeter who report their evidence in a pair of ... on December 2. Those marine worms play a key ecological ... Work by Stephanie Wright from the University of Exeter ...
... grant of more than $2 million from the National Institutes ... Initiative for Maximizing Student Development, or IMSD. She is the ... Chemotherapy/Materials in the Department of Chemistry at LSU. "The ... us the opportunity to continue to provide research training and ...
... by U.S. Forest Service researchers shows that reforesting the ... agricultural lands and the amount of sediment entering the ... The journal Ecological Engineering recently published the ... Station scientists Ying Ouyang, Ted Leininger, and Matt Moran. ...
Cached Biology News:Microplastics make marine worms sick 2LSU receives $2 million from NIH for biomedical sciences training for underrepresented students 2Study shows reforestation in Lower Mississippi Valley reduces sediment 2
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... 2014  Kainos Capital, a firm specializing in acquiring ... it has acquired the Slim-Fast brand from Unilever. Unilever ... of the transaction were not disclosed. Slim-Fast ... that markets ready-to-drink shakes, powders, bars and snacks to ... and in the United Kingdom ...
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Swell new sensors 2
... , , , , , , ... Christian Bauer, Oliver Klotzsche, CCS Cell Culture Service GmbH, Falkenried , ... AG, Germany, , , , , , ... RNA isolation procedures are based on a mono-phasic solution , ...
... , , , , , ... Resolve DNA fragments on a Low Melting Point (LMP) agarose gel in ... recommended , as TBE gels are much more difficult ... a longwave UV light, , and carefully cut out ...
... of Cosmids using Eppendorf's Perfectprep Plasmid , Mini ... , , James Griffith and Kim Vollmer , ... Kimberly Vollmer, Brinkmann Instruments, Biosytems Application Lab, Westbury, , NY ... Abstract , Cosmids are commonly used vectors ...
Cached Biology Technology:Easy preparation of total RNA from cultured cells with TRIzol and , Eppendorf Phase Lock Gel 2Easy preparation of total RNA from cultured cells with TRIzol and , Eppendorf Phase Lock Gel 3Easy preparation of total RNA from cultured cells with TRIzol and , Eppendorf Phase Lock Gel 4Easy preparation of total RNA from cultured cells with TRIzol and , Eppendorf Phase Lock Gel 5Easy preparation of total RNA from cultured cells with TRIzol and , Eppendorf Phase Lock Gel 6Recovery of DNA from LMP Agarose1 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 3Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 4Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 5
UBN-1 (C-20)...
P2A4...
pETDuet-1 is designed for the coexpression of two target genes....
... Cl- Cotransporter-1 (KCC1). The ... sequence homology with other ... The immunogen sequence is ... mouse, porcine and rabbit. ...
Biology Products: