Navigation Links
Cow vaccines go vroom
Date:8/17/2010

In much of Africa, a herd of cattle is more than just cows. It's a savings account, protein store, dowry, funeral fund, symbol of wealth, and hedge against drought. For many smallholder farmers, the loss of even a single cow to disease can spell ruin.

Yet a grievous number of cattle in sub-Saharan Africa get sick: one estimate puts annual losses from disease at $40 billion, some twenty-five percent of the total value of livestock production in the region.

John Barlow, professor of animal sciences at the University of Vermont, thinks the cows in the university's research herd may be able to help.

"Many cattle diseases in sub-Saharan Africa might be prevented if we had better vaccines," he says, "but the way we have traditionally created vaccines is expensive and takes a lot of time."

That's why he's leading an international project that aims to better understand the molecular workings of cow immune systems -- and accelerate the development of vaccines for two critical cattle diseases: East Coast fever and foot-and-mouth disease.

Barlow and his colleagues in Kenya, Denmark and at the U.S. Department of Agriculture are supported by a new three-year grant from the National Science Foundation.

"In the first year, we will be studying the cattle in the University of Vermont herd to understand the diversity of their immune function genes," Barlow says.

Then, applying this knowledge, the team will use a new technology that has been accelerating human vaccine development, but, until now, hasn't been applied to cows: so-called MHC tetramers. These synthetic molecules allow researchers to quickly get a view of what proteins in the invading virus or parasite are likely to spark a strong immune response in the host animal.

"These proteins are the key vaccine candidates," says Barlow -- and can be tested in lab cell lines.

The MHC -- or "major histocompatibility complex" -- is a large family of g
'/>"/>

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists use computer algorithms to develop seasonal flu vaccines
2. New bacterial signaling molecule could lead to improved vaccines
3. Prescription drug could boost effects of vaccines for HIV and other diseases
4. Vaccines preventing pneumococcal disease protect African children with sickle-cell disease
5. GEN reports on the promise of DNA vaccines
6. Major breakthrough may pave the way for therapeutic vaccines
7. Bug barcode readers hold out promise of universal vaccines
8. Pitt researchers find promising candidate protein for cancer prevention vaccines
9. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
10. Princeton teams analysis of flu virus could lead to better vaccines
11. New evidence explains poor infant immune response to certain vaccines, says MU researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... has been known about what genetic changes transform wild ... one of whom is a University of Montana assistant ... controlling the development of the brain and the nervous ... was published Aug. 28 in Science and ... at http://www.sciencemag.org/ ., The domestication of animals and ...
(Date:8/29/2014)... in German . ... natural nitrogen cycle on Earth and in biological wastewater ... to depend on nitrite as their source of energy. ... a microbiologist at the University of Vienna, has now ... alternative source of energy. The oxidation of hydrogen with ...
(Date:8/29/2014)... Bend them, stretch them, twist them, fold them: modern ... extraordinary technological potential, whether as artificial skin or electronic ... use remains a challenge but a new way of ... could be a game-changer. , Previous success in ... on the use of precious gold and silver nanowires. ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Copper shines as flexible conductor 2
... to treat bacterial infections causes a continual and vicious ... and spread of resistant strains, forcing the use of ... what if it doesn,t have to be that way? ... Biochemistry and Molecular Biology,s annual meeting, titled "Driving backwards ...
... We all know that eating a calcium-rich diet is ... concept is clearly on display in any elementary school ... with celebrity icons encouraging children to make sure they ... urging school-aged children to pay attention to their dairy ...
... genes out of action allows researchers to learn what genes ... Utah biologists pioneered the field. Mario Capecchi won a Nobel ... to cripple fruit fly genes. Now, biologist Erik Jorgensen and ... nematode worms. "We developed a method that allows us ...
Cached Biology News:Putting bacterial antibiotic resistance into reverse 2Study suggests a much earlier onset for bone problems 2Study suggests a much earlier onset for bone problems 3Worm genes KO'd 2Worm genes KO'd 3Worm genes KO'd 4Worm genes KO'd 5
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo ... ICOTF), today reported financial results for the six ... otherwise, are expressed in Canadian dollars and presented ... Second Quarter 2014 Highlights , Announced ... acuity (VA) primary endpoint for subjects enrolled in ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 A major ... the biotech start-up dense realm of Boston-Cambridge, is gaining ... able investors. James Sherley, the Director of Boston’s Adult ... the local and national visibility of his company an ... 2013. , In addition to a social media marketing ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company to ... asks food processors and food handling professionals to prepare ... currently using to Best Sanitizers’ Alpet® E3 Plus ... fighting cross-contamination and the spread of pathogens in the ... key criteria that make a hand sanitizer most effective, ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... ATLANTA, May 1 CryoLife, Inc., (NYSE: ... company, announced today,that Harvey Morgan has been elected ... Morgan is a Managing Director at Bentley,Associates L.P., ... more than 35 years of investment banking experience ...
... accelerating market penetration and revenue growth, SCOTTSDALE, ... technology company that markets the Provant(R) Wound Therapy,System, ... as Vice,President of Marketing. Most recently Mr. Robey ... Inc (KCI) for the V.A.C.(R) Therapy,brand, during the ...
... SEATTLE, May 1 Therapies under development to ... growth factor,(IGF-1) to activate its target receptor could ... gene -- p53 -- is already,compromised, according to ... Center., IGF-1 is a polypeptide hormone that ...
Cached Biology Technology:Harvey Morgan Joins CryoLife Board of Directors 2Regenesis Biomedical Advances Corporate Strategy by Appointing Vice President of Marketing 2New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor 2New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor 3
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
Mouse monoclonal antibody raised against a partial recombinant JRKL. NCBI Entrez Gene ID = JRKL...
... Polymorphic DNA Technologies also offers a DNA ... of templates including plasmids, PCR products, BACs, ... customer-provided templates such as purified plasmids or ... liquid handling robotics optimized for automated reaction ...
... a premium quality recombinant form of Thermus ... suitable for a wide range of PCR ... reproducible performance, each preparation is extensively tested ... NovaTaq DNA Polymerase possesses an integral 5′→3′ ...
Biology Products: