Navigation Links
Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
Date:3/22/2009

A ghostly property of matter, called quantum tunneling, may aid the quest for accurate, low-cost genomic sequencing, according to a new paper in Nature Nanotechnology Letters by Stuart Lindsay and his collaborators at the Biodesign Institute of Arizona State University. Tunneling implies that a particle, say an electron, can cross a barrier, when, according to classical physics, it does not have enough energy to do so.

Unraveling the DNA sequences of the human genome a decade ago was a remarkable achievement. Today, the task of sequencing some 3 billion chemical base pairs of the genomeenough information to fill a 20-volume encyclopediaremains a daunting challenge, thus far accomplished largely through brute force means. Such methods are typically slow and extravagantly expensive, (though costs have dropped considerably from the initial sequencing of the human genome, which took 11 years at a cost of $1 billion.)

Bringing the power of DNA sequencing to every individual will require new, affordable technologies to help mine the wealth of information DNA can provide concerning morphology, hereditary traits and predisposition to disease.

Various techniques for sequencing DNA have been used to determine the identities of the four nucleotide basesadenine, thymine, cytosine and guaninewhich make up the ladder rungs of the DNA's double helical structure. Most of these require snipping DNA into hundreds of thousands of short fragments, unzipping the helix and reading a few hundred to a few thousand bases at a time. Finally, all of the information from the DNA pieces is reassembled into a picture of the complete genome, with the help of massive computing power.

ASU Regents' Professor and Carson Presidential Chair of Physics and Chemistry, Stuart Lindsay, who also directs the Biodesign Institute's Center for Single Molecule Biophysics, summarizes one of the chief physical obstacles to more efficient identification of DNA
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-313-2010
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Discovering the secret code behind photosynthesis
2. Uncovering secrets of life in the ocean
3. Deep biosphere research points to new methods for recovering petroleum
4. Discovering drugs, biofuels in tropical seas
5. Recovering from a mass extinction
6. MSU researcher helps develop computer game for Ugandan children recovering from cerebral malaria
7. Rice eyes risks of quantum dots
8. New technique is quantum leap forward in understanding proteins
9. Strained quantum dots show new optical properties
10. Study shows quantum dots can penetrate skin through minor abrasions
11. Europe gets together to harness quantum physics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications
(Date:10/1/2014)... October 1, 2014 ... der Biowissenschaften   Die Biowissenschaften erlebten ... Gehen zahlreicher Detektionstechnologien. Einige davon sind Senkrechtstarter ... Die Photonen-Upconversion ist eine neuartige Detektionstechnologie, die ... Begeisterung aufgenommen wurde. Jetzt ist diese Technologie ...
(Date:9/30/2014)... visit the Mediterranean each year, but its deep-blue ... Earth. Almost 1,000 alien species, including fish, crustaceans, ... through human activities. In the open-access journal ... of researchers analyzed data from a new information ... how the introduction of alien species has changed ...
(Date:9/30/2014)... as something that we enjoy when we visit a national ... think of ourselves as a part of nature? A bird,s ... house? , The answers to these questions reflect different ... speech and in cultural artifacts. , A new Northwestern University ... Indian Center of Chicago and the Menominee tribe of Wisconsin, ...
Breaking Biology News(10 mins):Innovative Verwendungslösung für die Photonen-Upconversion 2Innovative Verwendungslösung für die Photonen-Upconversion 3Biodiversity in the Mediterranean is threatened by alien species 2The cultural side of science communication 2
... University professor of physics and astronomy Apparao Rao has ... Fellows are elected by their peers for outstanding contributions ... one half of 1 percent of the membership. ... nanotubes and for elucidating the properties of carbon nanotubes ...
... PITTSBURGHUniversity of Pittsburgh researchers have developed the first ... finding that could help diminish the environmental and ... of the super-strong materials commonly used in products, ... team has found that carbon nanotubes deteriorate when ...
... 16, 2008) Researchers from Virginia Commonwealth University have identified ... and suppress a key protein that is overexpressed in 90 ... to an effective gene therapy for cancer. According ... the Department of Human and Molecular Genetics and director of ...
Cached Biology News:Pitt researchers create non-toxic clean-up method for potentially toxic nano materials 2Researchers identify new anti-tumor gene 2
(Date:10/1/2014)... 01, 2014 METTLER TOLEDO’s newly improved ... precision balances as well as a dual range ... performance, the new SmartPan™ weighing pan delivers results up ... On all balances, ergonomic design details mean users no ... working for long periods in front of the balance. ...
(Date:10/1/2014)... , Oct. 1, 2014  Spherix Incorporated (Nasdaq: ... fostering and monetization of intellectual property, announced today ... VTech and Uniden in the U.S. District Court ... has been rescheduled for November 10, ... 2, 2014.  The Court Order setting the Markman ...
(Date:10/1/2014)... 2014 Today the National Institutes ... grants for the Brain Research through Advancing Innovative ... develop and revolutionize new methods of understanding the ... brain. This first round of grants totaling $46 ... allocated to more than 100 investigators in 15 ...
(Date:10/1/2014)... 2014 Slone Partners , a ... IT, and Laboratory Testing industries, reported a 120% increase ... director level and above from July 2013 to July ... top of rapid breakthroughs in diagnostics, reimbursement has failed ... have been forced to fold, consolidate, or carry on ...
Breaking Biology Technology:METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 2METTLER TOLEDO’s XS Balance Line Delivers Performance and Ergonomics To Safeguard Health in the Workplace 3Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2
... , , , Genetic reporter ... regulatory promoter and enhancer sequences as well as transcription factors. , ... enhancer) is cloned , together with the reporter ... used to transfect cells. Quantification of the reporter indirectly provides , ...
... , , , , Using eukaryotic ... to a hypoosmolar buffer system and short pulses in the s-range. , ... of sample resistance (patent pending)., , , ... Two cell lines (mouse fibroblast cells, human T-lymphocytes) were transfected ...
... , , , , , , PLG can be used ... The basic protocol given here works with E. coli cultures grown for 1214 , ... , ml Terrific Broth. , , ... 10,000 x g for 5 minutes at room , temperature. ...
Cached Biology Technology:Genetic Reporter Systems 2Genetic Reporter Systems 3Genetic Reporter Systems 4Basic Plasmid DNA Isolation Protocol 2
... Microplate Rack inserts fit into ... and allow you to greatly ... shake deepwell format plates at ... plates from the shaker at ...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
Spaced cover glasses to promote effective hybridization...
prototype Nco I...
Biology Products: