Navigation Links
Countries unite to reduce animal use in product toxicity testing worldwide

Representatives from four international agencies, including the director of the U.S. National Toxicology Program (NTP), today signed a memorandum of cooperation that could reduce the number of animals required for consumer product safety testing worldwide. The agreement between the United States, Canada, Japan and the European Union will yield globally coordinated scientific recommendations on alternative toxicity testing methods that should speed their adoption in each of these countries, thus reducing the number of animals needed for product safety testing. The memorandum is available at .

"Signing this international agreement demonstrates our commitment to finding and advancing alternatives to animal testing," said Linda Birnbaum, Ph.D., director of the NTP and National Institute of Environmental Health Sciences, part of the National Institutes of Health. "This agreement will help us achieve greater efficiency by avoiding duplication of effort and allowing us to leverage limited resources."

Birnbaum signed as the U.S. representative on behalf of the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), one of the national validation organizations participating in the agreement. Others who signed include Elke Anklam, Ph.D., for the European Centre for the Validation of Alternative Methods (ECVAM), David Blakey, D.Phil., for the Environmental Health Science and Research Bureau within Health Canada, and Masahiro Nishijima, Ph.D. for the Japanese Centre for the Validation of Alternative Methods (JaCVAM).

The agreement promotes enhanced international cooperation and coordination on the scientific validation of non- and reduced-animal toxicity testing methods. If the toxicity testing methods are shown to be reproducible based on strong scientific information, and able to accurately identify product related health hazards, the tests are more readily accepted by regulatory agencies.

"The memorandum covers three critical areas of test method evaluation: validation studies, independent scientific peer review meetings and reports, and development of test method recommendations for regulatory consideration," said Marilyn Wind, Ph.D., chair of the Interagency Coordinating Committee on the Validation of Alternative Methods and a scientist at the Consumer Product Safety Commission (CPSC).

"This international cooperation will benefit both people and animals," said William Stokes, D.V.M., director of NICEATM and executive director of ICCVAM. Stokes is also an assistant surgeon general in the U.S. Public Health Service. "The cooperation will serve an important role in translating research advances into more effective public health prevention tools. It will speed the adoption of new test methods based on advances in science and technology that will provide more accurate predictions of safety or hazard. Animal welfare will also be improved by the national and international acceptance of alternative test methods that reduce, refine, and replace the use of animals."

Federal agencies are committed to the welfare of animals used in research. All animals used in federally-funded research are protected by laws, regulations and policies to ensure they are used in the smallest number possible and with the greatest commitment to their comfort. ICCVAM is working to promote the development and validation of alternative test methods. Alternative test methods are those that accomplish one or more of the 3Rs - reducing the number of animals used in testing, or refining procedures so animals experience less pain and distress, or replacing animals with non-animal systems.

"We are very pleased to be part of this effort and to continue our already successful collaboration in a formalized manner," said Elke Anklam, Ph.D., director for the Institute of Health and Consumer Protection for the European Commission's Joint Research Centre, where the European Centre for the Validation of Alternative Methods, ICCVAM's European counterpart, is located. Anklam has signed the agreement as representative on behalf of the EU. Her colleague Joachim Kreysa, Ph.D., the recently appointed head of ECVAM, further remarked, "I am enthusiastic about the agreement. Our collaboration will help to identify and embrace scientifically sound and robust new testing approaches, ensuring that safety assessments are never compromised, while at the same time reduce the need for animal testing."

"Although we've had informal collaborations over the years, this more formal agreement will allow us to work more efficiently and effectively," said Hajime Kojima, Ph.D., director of the Japanese Centre for the Validation of Alternative Methods.

David Blakey, D.Phil., director of the Environmental Health Science and Research Bureau within Health Canada, added that the effort is a major step forward. "Increased coordination, collaboration and communication will clearly enhance the global progress in this important area."


Contact: Robin Mackar
NIH/National Institute of Environmental Health Sciences

Related biology news :

1. HPV DNA test identifies cervical pre-cancerous disease in developing countries with 90% success rate
2. Early cessation of breastfeeding by HIV+ women in poor countries and child survival
3. Fertility treatment in developing countries; a cycle of IVF for less than $200
4. Extreme nausea and vomiting varies among pregnant women from different countries
5. Conservation of freshwater fish biodiversity: a challenge for the countries of the South
6. Sanitation investment in poor countries would yield $9-to-1 benefits in productivity, health: UN
7. New way to produce high-vitamin corn could improve nutrition in developing countries
8. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
9. Hand hygiene initiative aims to decrease healthcare-associated infection in developing countries
10. Data on life expectancy show many countries clustered in high mortality traps
11. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
Post Your Comments:
(Date:11/20/2015)... 20, 2015 NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... , was recently interviewed on The RedChip Money ... this weekend on Bloomberg Europe , Bloomberg Asia, ... --> NXTD ) ("NXT-ID" or the "Company"), a ...
(Date:11/17/2015)... , November 17, 2015 Paris ...   --> Paris from 17 th ... DERMALOG, the biometrics innovation leader, has invented the first combined ... on the same scanning surface. Until now two different scanners ... one scanner can capture both on the same surface. ...
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever that ... muscular dystrophy (DMD) has provided a new lead for ... Hospital, the Broad Institute of MIT and Harvard and ... . Cell, pinpoints a ... "escape" the disease,s effects. The Boston Children,s lab of ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... device company specializing in imaging technologies, announced today that it ... as part of the Horizon 2020 European Union Framework Programme ... a large-scale clinical trial in breast cancer. , ... , --> --> The ...
(Date:11/25/2015)... 2 nouvelles études permettent d , identifier ... souches bactériennes retrouvées dans la plaque dentaire des ... Ces recherches  ouvrent une nouvelle voie ... l,un des problèmes de santé les plus fréquemm ... --> 2 nouvelles études permettent d , ...
(Date:11/25/2015)... Nov. 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... President and CEO of Neurocrine Biosciences, will be presenting ... New York . ... website approximately 5 minutes prior to the presentation to ... the presentation will be available on the website approximately ...
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015 ... that management will participate in a fireside chat discussion ... New York . The discussion is ... Time. .  A replay will ... Contact:  Media Contact:McDavid Stilwell  , Julie NormartVP, Corporate ...
Breaking Biology Technology: