Navigation Links
Counting duplicated genome segments now possible
Date:8/30/2009

ch regions of the human genomes because their sequences are not unique.

Before this study, by using different methods scientists could analyze the entire genome of a person and say that an individual has more or fewer copies of a particular gene, but not the absolute number of copies. For example, scientists have known that some people have an increased copy-number of a gene that confer some resistance to HIV, but couldn't tell how many.

The UW researchers further examined the much-studied genomes from three healthy individuals: a European (DNA research pioneer James D. Watson), a Yoruban African individual from Nigeria, and a Han Chinese. The researchers were able to predict copy-number differences among the individuals, even when there were many copies, such as 5 in one person compared to 12 in another. The researchers conservatively validated 113 genes that were copy-number variable among the three people, but more genes are suspected to be copy-number variable. Several of the validated gene differences are known to be of biomedical relevance. They include, for example, genes related to eye and skin diseases, and many others that play a role in the immune system. The researchers noted that several human genes with the most variable copy numbers correspond to a torrent of segmental duplications that occurred within the common ancestor of apes and humans.

In talking about their study, the researchers mentioned that next-generation technology for sequencing the human genome has far greater detection power and costs substantially less than the traditional sequencing method known as Sanger sequencing. The new technologies are beginning to distinguish subtle dissimilarities between nearly identical gene copies.

"This can provide researchers with a more accurate assessment of specific gene content and insight into functional constraints," Alkan explained.

"The newer, faster genome sequencing platforms," Alkan added, "ma
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The straight poop on counting tigers
2. Counting sheep in climate change predictions
3. Carbon accounting from atmospheric measurements -- the aircraft perspective
4. Study shows Californias autism increase not due to better counting, diagnosis
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. When accounting for the global nitrogen budget, dont forget fish
7. Mars Express -- 5000 orbits and counting
8. Faster, cheaper way to find disease genes in human genome passes initial test
9. Genome duplication responsible for more plant species than previously thought
10. After dinosaurs, mammals rise but their genomes get smaller
11. Springer to collaborate with the Human Genome Organization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... that digital distribution of media will have lower ... least when file sizes are large. , That,s ... Journal of Industrial Ecology that looked ... such as PlayStation3. Researchers found that Blu-ray Discs ... emissions than game files downloaded over broadband Internet. ...
(Date:9/2/2014)... New research suggests that professional baseball pitchers with poor core ... in a single season because of injury than are pitchers ... and pelvis. , In the study, 347 pitchers were assessed ... in their pelvis as they raised a leg to step ... at least 30 days cumulative, not consecutive during ...
(Date:9/2/2014)... September issue of The FASEB Journal , ... diagnose the leading cause of blindness in adults, ... This advance involves quantifying the early molecular changes ... vessels. Using new probes developed by scientists, they ... of diabetic retinopathy. , "My goal is to ...
Breaking Biology News(10 mins):In pro baseball pitchers, weak core linked to more missed days 2In pro baseball pitchers, weak core linked to more missed days 3Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2
... a team led by researchers from Caltech has for ... of chemoreceptorsthe receptors that sense and respond to chemical ... specific architecture is the same throughout a wide variety ... stable, universal structure that has been conserved over evolutionary ...
... new university/industry network to pursue the development of biomaterials, ... increasing incidence of eye disease. The 20/20: NSERC ... as part of the Natural Sciences and Engineering Research ... Minister of State (Science and Technology) Gary Goodyear today ...
... cell researcher Treena Livingston Arinzeh will discuss current stem cell ... for bone fracture and osteoarthritis treatments, spinal cord repair, and ... The event will be held Sept. 29, 2009, at ... floor of the NJIT Campus Center. The ...
Cached Biology News:Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 2Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 3Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells 4New research network at McMaster aims to build a better eye 2
(Date:8/30/2014)... August 31, 2014 The Global ... professional and in-depth study on the current state ... and China. , The report provides a basic ... industry chain structure. Global market analysis and Chinese ... on history, developments, trends and competitive landscape of ...
(Date:8/29/2014)... 2014 The global companion diagnostics ... 2019. It is expected to grow at a ... was valued at $1.8 billion in 2013, according ... Research. , For more information regarding analysis details ... The research report, titled “Companion Diagnostics Market (Breast ...
(Date:8/29/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the six months ended June 30, 2014. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... , Announced top-line results related to the eight ... enrolled in the Phase 2 iDEAL Study evaluating ...
(Date:8/29/2014)... 29, 2014 Due to a misstatement posted ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... cell therapy research that might benefit ALS patients. Because ... new stem cell technologies and therapeutic applications, FRC listed ASCTC ... Challenge donors who wish not to support research that ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3
... BEIJING, Aug. 30, 2011 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NASDAQ: ... in China, announced today that Dr. Weidong Yin, President and ... Helen Yang, Investor Relations Manager, are scheduled to attend four ... Rodman & Renshaw Annual Global Investment Conference, New ...
... ProteinSimple today introduced a revolutionary new system for protein analysis, ... complete reinvention of the Western Blot, and is truly a ... 30 years, researchers have access to a completely automated, walk-away ... was invented in 1979 and to this day remains the ...
... Technologies Corporation (NASDAQ: LIFE ) today announced ... Sciences Conference on Tuesday, September 20 at 8:00am ET. ... will present on behalf of the company. The company ... three weeks following the conference on the Life Technologies, ...
Cached Biology Technology:Sinovac to Participate in Four Investor Conferences in September 2011 2ProteinSimple Reinvents the Western Blot 2Life Technologies to Present at the UBS 2011 Global Life Sciences Conference 2
4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
...
EoProbe Eosinophil Staining Kit, 1 Kit...
... ELISA Development kit contains the basic components ... to measure natural and recombinant rat L-Selectin ... Each kit contains sufficient materials to run ... that the following conditions are met: ...
Biology Products: