Navigation Links
Counting duplicated genome segments now possible
Date:8/30/2009

A newly designed computational method has proven its usefulness in counting copies of duplicated genome sequences and in doing initial assessments of their contents, according to a study to be published Aug. 30 in Nature Genetics. The number of copies of particular DNA segments can differ from one person to the next.

The researchers named their method mrFAST, an acronym for micro-read Fast Alignment Search Tool. The study is titled, "Personalized Copy Number and Segmental Duplication Maps Using Next Generation Sequencing." The lead authors are Dr. Can Alkan, a senior fellow, and Jeffrey M. Kidd, a graduate student, both in the Department of Genome Sciences at the University of Washington (UW). Dr. Evan E. Eichler, UW professor of genome sciences, is the senior author.

Segmental duplications in the human genome have been associated with susceptibility and resistance to disease. Duplicated segments have been linked to such disorders as lupus, Crohn's disease, mental retardation, schizophrenia, color blindness, psoriasis, and age-related macular degeneration. Segmental duplications often contain duplicated genes, many of which have an unknown function. Individuals have different numbers of copies of some of these duplications. Determining the number, content, and location of segmental duplications is an important step in understanding the health significance of gene copy-number variation.

"New computational methods, combined with next-generation DNA sequencing technology, has provided for the first time an accurate census of specific genes that exist in varying number of copies," Alkan said.

"This is a way to deal with some of the most complex regions of the human genome and do what might appear to be a simple thing: Count whether a person has one, two, three or more copies of a gene," explained Kidd. "In fact, such counting is surprisingly difficult." Many standard genome analyses exclude duplication-rich or repeat-ri
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The straight poop on counting tigers
2. Counting sheep in climate change predictions
3. Carbon accounting from atmospheric measurements -- the aircraft perspective
4. Study shows Californias autism increase not due to better counting, diagnosis
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. When accounting for the global nitrogen budget, dont forget fish
7. Mars Express -- 5000 orbits and counting
8. Faster, cheaper way to find disease genes in human genome passes initial test
9. Genome duplication responsible for more plant species than previously thought
10. After dinosaurs, mammals rise but their genomes get smaller
11. Springer to collaborate with the Human Genome Organization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... of wild foods, autumn harks a season of bounty. ... luring intrepid collectors to woodlands in search of elusive ... in the allure of the treasure hunt, and their ... existence. But are the mushrooms which you are eating ... diverse yet vastly underdocumented although some estimates range ...
(Date:9/15/2014)... division has evolved a simple, mechanical solution to ... Sept. 11 Science Express. ... and misalignments that lead to infertility, miscarriage, or ... division cause these problems, but what exactly goes ... of the Wellcome Trust Center for Cell Biology ...
(Date:9/15/2014)... naturally across all kingdoms of life and constitute a ... of biological activities. The presence of halogen substituents in ... molecular properties. , One of the Holy ... late-stage, site-specific incorporation of a halogen atom into a ... (one of the most inert chemical bonds known in ...
Breaking Biology News(10 mins):What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 3Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Pitt chemical biologist finds new halogenation enzyme 2
... HOUSTON, Feb. 5, 2009 Gov. Rick Perry today announced ... of Houston through the Texas Emerging Technology Fund (ETF). ... recruited a top hormones researcher and his team to carry ... technologies at a world-class center to be established by UH ...
... DAVISA major cause for biodiversity may be biodiversity itself, ... California, Davis, whose newly published research shows that when ... the apple, that triggered a cascading effect on the ... parasitic wasp ( Diachasma alloeum ) that attacks the ...
... It,s not uncommon for students to consume energy drinks to ... drinks are the coffee of a new generation," says Stphanie ... nutrition think-tank. "These drinks are made up of sugar and ... According to a 2008 report by Agriculture and Agri-Food Canada, ...
Cached Biology News:Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant 2Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant 3Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant 4Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant 5Host shift triggers cascading effect on ecosystem, research finds 2
(Date:9/17/2014)... (PRWEB) September 17, 2014 The ... (ACRES) , a multi-stakeholder non-profit collaborative building a ... in clinical research, today announced Phase 3 of ... , Amir H. Kalali, Vice-President, Global ... Arti Bajpai, President, Compliance and Quality Integration (CQI) ...
(Date:9/16/2014)... This report analyzes the worldwide markets for Bioinformatics in US$ ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... estimates and forecasts are provided for the period 2013 through ... markets. Market data and analytics are derived from primary and ...
(Date:9/16/2014)...  Biocom, the association representing the Southern ... th Annual National Health Information Technology Week, which ... improving our health care system. " ... world,s most vibrant hubs for health IT and digital ... genomic testing to remote patient monitoring," said Joe ...
(Date:9/16/2014)... cell phones to cars and flashlights, batteries play ... technology companies constantly are seeking ways to improve ... time using a water-based solution, researchers at the ... more efficient nuclear battery that could be used ... source in automobiles and also in complicated applications ...
Breaking Biology Technology:Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23Biocom Recognizes National Health IT Week 2
... - Three years ago, entrepreneurs Nathan Lustig and John ... oft-criticized textbook exchange at the University of Wisconsin-Madison . ... being ripped off. He saw students regularly selling used books ... price, and he saw an opportunity to cut out the ...
... Friedman's 2005 New York Times' article "It's a ... World is Flat: A Brief History of the Twenty-First Century"), he ... trip to the New World. Whereas Columbus told the Spanish king ... his wife that the world, in fact, is not round but ...
... all the hype, all the emotional arguments, and all the ... , ,In the great race for global competitiveness, economic development ... for broadband connectivity is the need for speed. Thats all ... need to know. , , AT&T's Project Lightspeed ...
Cached Biology Technology:Website targets college students nationwide 2Website targets college students nationwide 3Website targets college students nationwide 4The flattening world and its impact on U.S. biotech 2The flattening world and its impact on U.S. biotech 3The flattening world and its impact on U.S. biotech 4The flattening world and its impact on U.S. biotech 5The flattening world and its impact on U.S. biotech 6Broadband blues: Don't fall for Lightspeed hype 2Broadband blues: Don't fall for Lightspeed hype 3Broadband blues: Don't fall for Lightspeed hype 4Broadband blues: Don't fall for Lightspeed hype 5
Mouse monoclonal antibody to ALAS2 - aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant PRG4. NCBI Entrez Gene ID = PRG4...
Mouse monoclonal antibody raised against a partial recombinant FAAH. NCBI Entrez Gene ID = FAAH...
Biology Products: