Navigation Links
Countering brain chemical could prevent suicides
Date:12/14/2012

EAST LANSING, Mich. --- Researchers have found the first proof that a chemical in the brain called glutamate is linked to suicidal behavior, offering new hope for efforts to prevent people from taking their own lives.

Writing in the journal Neuropsychopharmacology, Michigan State University's Lena Brundin and an international team of co-investigators present the first evidence that glutamate is more active in the brains of people who attempt suicide. Glutamate is an amino acid that sends signals between nerve cells and has long been a suspect in the search for chemical causes of depression.

"The findings are important because they show a mechanism of disease in patients," said Brundin, an associate professor of experimental psychiatry in MSU's College of Human Medicine. "There's been a lot of focus on another neurotransmitter called serotonin for about 40 years now. The conclusion from our paper is that we need to turn some of that focus to glutamate."

Brundin and colleagues examined glutamate activity by measuring quinolinic acid -- which flips a chemical switch that makes glutamate send more signals to nearby cells -- in the spinal fluid of 100 patients in Sweden. About two-thirds of the participants were admitted to a hospital after attempting suicide and the rest were healthy.

They found that suicide attempters had more than twice as much quinolinic acid in their spinal fluid as the healthy people, which indicated increased glutamate signaling between nerve cells. Those who reported the strongest desire to kill themselves also had the highest levels of the acid.

The results also showed decreased quinolinic acid levels among a subset of patients who came back six months later, when their suicidal behavior had ended.

The findings explain why earlier research has pointed to inflammation in the brain as a risk factor for suicide. The body produces quinolinic acid as part of the immune response that
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
2. Pan-European organizations call for an advanced understanding of the human brain
3. Does the brain become unglued in autism?
4. How the common cat parasite gets into the brain
5. Research shows immune system response is detrimental to novel brain cancer therapy
6. Musical duets lock brains as well as rhythms
7. Double duty: Immune system regulator found to protect brain from effects of stroke
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. A 3-D light switch for the brain
11. Neurons made from stem cells drive brain activity after transplantation in laboratory model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... the world, leprosy and tuberculosis live side-by-side. Worldwide ... per year, with nearly all of them occurring ... vaccine Bacille Calmette-Guerin, or BCG, provides only partial ... more potent vaccine is needed to combat both ... weapon against both diseases., In a study published ...
(Date:8/19/2014)... have identified a biomarker strongly associated with basal-like ... resistant to many types of chemotherapy. The biomarker, ... for new therapeutics designed to treat this often ... taken from The Cancer Genome Atlas, molecular biologists ... powerful computational and bioinformatics techniques to detect patterns ...
Breaking Biology News(10 mins):Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3
... type of sperm a male produces, according to new research ... the Proceedings of the National Academy of Sciences ... sperm of many species of African cichlids. These fish have ... where females mate with many males in quick succession. ...
... certain marginalized groups including the mentally ill, the ... Latinos fare worse than others in the aftermath ... Now, a new study by ... experience greater terrorism-related fears and make more behavioral changes ...
... are killers. They strike without warning, causing ... percent of all deaths in the United States., ... associated with arrhythmias. Their findings, reported in The ... to novel arrhythmia treatments., "The current antiarrhythmic drugs ...
Cached Biology News:The more promiscuous the female, the speedier the sperm 2Disabled and other vulnerable groups more susceptible to terrorism fears 2Studies point to novel target for treating arrhythmias 2Studies point to novel target for treating arrhythmias 3
(Date:8/20/2014)... of patented university inventions licensed to biotechnology firms ... commercialization. To open these roadblocks, the researchers suggest ... the discovery stage could lead to faster commercialization ... derived from discoveries made in university laboratories and ... during clinical trials, which have a high failure ...
(Date:8/20/2014)... first time, chemists have succeeded in measuring vibrational motion ... The study reveals how vibration of a single molecule ... , The study was performed at the University of ... University of Jyvskyl works as a visiting fellow under ... study. The second team was lead by Professor Eric ...
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
(Date:8/20/2014)... BOSTON , Aug. 20, 2014  PAREXEL International ... it will be presenting at the Baird Healthcare Conference ... President and Chief Financial Officer, will be making a ... p.m. EDT on Wednesday, Sept. 3, 2014. ... through the "Investors" section of PAREXEL,s website at ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Seeing a molecule breathe 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3PAREXEL International To Present At Baird Healthcare Conference 2
... Reportlinker.com announces that a new market ... Animal Husbandry Equipment ... http://www.reportlinker.com/p0181483/Animal-Husbandry-Equipment-Market-in-United-States-Business-Report-2011.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Livestock ... research of animal husbandry equipment market in ...
... DIEGO, Dec. 13, 2011  Astellas Pharma Inc. (Tokyo: 4503, ... results from an interim analysis of a Phase 2 ... (AML) were presented at the 53rd Annual Meeting of ... California.  Data were also presented from two additional posters: ...
... , Dr. Vivek Desai, MD, Hosmac ... Emeritus, Infosys Technologies Clear winner under Healthcare ... appreciation added to his hat of success at the felicitation ceremony ... Dr. Vivek Desai, Managing Director, Hosmac India Pvt. Ltd. is ...
Cached Biology Technology:Animal Husbandry Equipment Market in United States: Business Report 2011 2Animal Husbandry Equipment Market in United States: Business Report 2011 3Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 2Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 3Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 4Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 5Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 6Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 7Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society 8Sweet Success for Hosmac India Pvt. Ltd. at ET NOW-IndiaMART Leaders of Tomorrow Awards 2011 2Sweet Success for Hosmac India Pvt. Ltd. at ET NOW-IndiaMART Leaders of Tomorrow Awards 2011 3
... F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α ... containing both a double bond at ... group at C-15. Similar to 15(S)-latanoprost, ... a potential impurity in most commercial ...
ACS Reagent Grade C 19 H 14 O 5 S Formula Weight: 354.38 PRODUCT SPECIFICATIONS Form: Rust/red crystalline powder Clarity of Solution: Passes test Visual Transition Interval: pH 6.8 - Yellow pH 8.2...
... Nop1p/Fibrillarin (monoclonal) Nop1p/Fibrillarin was ... of bakers yeast, Saccharomyces cerevisiae (accession ... for yeast viability and is localized ... of Nop1p is fibrillarin (accession P22087) ...
... bind specifically to Fc regions of many ... conjugates are commonly used as affinity adsorbents ... from serum, hybridoma ascites fluids, tissue culture ... are also commonly used to capture immune ...
Biology Products: