Navigation Links
Countering brain chemical could prevent suicides
Date:12/14/2012

EAST LANSING, Mich. --- Researchers have found the first proof that a chemical in the brain called glutamate is linked to suicidal behavior, offering new hope for efforts to prevent people from taking their own lives.

Writing in the journal Neuropsychopharmacology, Michigan State University's Lena Brundin and an international team of co-investigators present the first evidence that glutamate is more active in the brains of people who attempt suicide. Glutamate is an amino acid that sends signals between nerve cells and has long been a suspect in the search for chemical causes of depression.

"The findings are important because they show a mechanism of disease in patients," said Brundin, an associate professor of experimental psychiatry in MSU's College of Human Medicine. "There's been a lot of focus on another neurotransmitter called serotonin for about 40 years now. The conclusion from our paper is that we need to turn some of that focus to glutamate."

Brundin and colleagues examined glutamate activity by measuring quinolinic acid -- which flips a chemical switch that makes glutamate send more signals to nearby cells -- in the spinal fluid of 100 patients in Sweden. About two-thirds of the participants were admitted to a hospital after attempting suicide and the rest were healthy.

They found that suicide attempters had more than twice as much quinolinic acid in their spinal fluid as the healthy people, which indicated increased glutamate signaling between nerve cells. Those who reported the strongest desire to kill themselves also had the highest levels of the acid.

The results also showed decreased quinolinic acid levels among a subset of patients who came back six months later, when their suicidal behavior had ended.

The findings explain why earlier research has pointed to inflammation in the brain as a risk factor for suicide. The body produces quinolinic acid as part of the immune response that
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
2. Pan-European organizations call for an advanced understanding of the human brain
3. Does the brain become unglued in autism?
4. How the common cat parasite gets into the brain
5. Research shows immune system response is detrimental to novel brain cancer therapy
6. Musical duets lock brains as well as rhythms
7. Double duty: Immune system regulator found to protect brain from effects of stroke
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. A 3-D light switch for the brain
11. Neurons made from stem cells drive brain activity after transplantation in laboratory model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 30, 2014  HITLAB SM , a healthcare ... its inaugural HITLAB Innovators Summit SM on ... HITLAB will partner with the Clinton Foundation,s Health ... ProtoHack, Columbia Business School Alumni Club of ... Engineering and Operations Research, bringing together leaders in ...
(Date:10/30/2014)... UT Arlington bioengineering professor has received a $1.04 ... to regenerate cartilage tissue and reduce osteoarthritis using ... injection of microscaffolding made of biodegradable polymers., Liping ... the bioengineering department, said the research is primarily ... on the battlefield., "We,ve found that if we ...
(Date:10/30/2014)... German . ... to behave socially? This is one of the central ... studies assumed that it is almost impossible to control ... Planck Institute for Evolutionary Biology have now demonstrated that ... cooperative behaviour of others. However, the possibilities available to ...
Breaking Biology News(10 mins):HITLAB Announces Inaugural HITLAB Innovators Summit 2HITLAB Announces Inaugural HITLAB Innovators Summit 3UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4
... announced Aug. 2 that a team of engineers at ... to design a battery management system for lithium-ion batteries ... is a particularly challenging project because the electrochemical reactions ... form. The project is one of 12 that ...
... finding confirming the extinction of the Javan rhinoceros in Vietnam ... these prehistoric creatures living in Indonesia., "We still have a ... we have to determine the profile of the remaining group," ... confirmed the demise of the Javan rhinoceros population living in ...
... are testing a way to determine the status of ... mothers and their babies. Supported by a two-year, ... Institute of Child Health and Human Development of the ... fetal cells for genetic study within the first two ...
Cached Biology News:$3.2 million to develop battery management system for electric-car batteries 2$3.2 million to develop battery management system for electric-car batteries 3$3.2 million to develop battery management system for electric-car batteries 4Wayne State researchers working to improve genetic analysis, disorder detection 2
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... , Oct. 30, 2014  Ardelyx, Inc. (NASDAQ: ... focused on cardio-renal, gastrointestinal and metabolic diseases, today ... financial results on Thursday, November 6, 2014. Following ... a live conference call and webcast at 4:30pm ... provide a business update. The live ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Rancho ... that they have manually curated public data source ... profit customers. the data is now available for ... and unifies public and internal data sources for their ... knowledge out of the data that becomes more easily ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories , ... the Board, to the National Stem Cell Ethics Committee ... by the Ministry of Health on behalf of the Government ... More than a year after Bahamian Parliament passed the ... Christie said the government has completed the accompanying regulations and ...
Breaking Biology Technology:Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... , , , , Gene Provides Yield Stability ... and LUDWIGSHAFEN, Germany, June 9, 2009 Monsanto Company (NYSE: ... naturally-occurring gene can help corn plants combat drought conditions and confer ... , The companies stated that they will use the gene in ...
... Early Diagnosis of Mitochondrial Diseases , , ... www.medomics.com ) announces an innovative test ... of disorders that can result in neurological dysfunction, ... and diabetes. The MEDomics mitochondrial genome test, MitoDx(TM), ...
... ... University College London, and Matrix Genomics, Inc. have identified a concise genetic signature found among ... general population. The signature is found in the LRRK2 gene located on chromosome 12. The ... ...
Cached Biology Technology:Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants 2Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants 3Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants 4Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants 5MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test 2MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test 3Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease 2Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease 3
... Pro260 reagents and supplies, for 10 ... sufficient to perform protein analysis with ... electrophoresis system. Supplied are 3 x ... Pro260 stain, 60 microliters Pro260 ladder ...
... discovery system miniaturizes, integrates and automates ... LabChip technology, the LabChip 3000 performs ... flow fashion. LabChip assays are separations-based, ... what is achievable in homogenous, well-based ...
... Mini-Workstations provide fast and reliable automation ... and drug development laboratories. Staccato Mini-Workstations ... to automate basic liquid handling and ... controlled with either Caliper's time proven ...
... range are part of your production or ... particle size is important to you. You ... the component populations in your sample every ... uses Photon Correlation Spectroscopy (PCS) , which ...
Biology Products: